Special note:
This is by far the most reckless article/study summary by med xpress I’ve read to date.
The takeaway is that supplementation may afford protection (I.e., “deficiency”), while the study itself cites a different solution altogether, without clarifying that abandoning the “western diet” may also be an effective solution (despite side mention thereof).
In fact, the upper limit of recommended manganese supplementation is 9-11mg, and OTC supplements deliver nearly 80% alone, thereby approaching toxic levels.
As well, the study authors cite the rarity of manganese deficiency prior to 40 years ago, but fail to cite how rare the genetic deficiency is among the populace.
The ONLY segment of the population this study serves are those who have been ill-served by their gastro mds and continue to suffer needlessly….unless you need yet another reason to rebel against the “western diet.”
Warning: Do NOT add standalone manganese supplements solely due to this post.
Ironically, this post also highlights one of the dangers of the keto fad.
(fire away)
The genetic variant allowed the study authors to realize the channel everyone must use. In other words, the exception proved the point.
My wife and I take 2.5 mg of manganese twice a day, by itself, with 50 mg of taurine, each time.
I had already reviewed all of our supplements and foods and determined we could easily, and safely, augment by 5+ mg a day.
Women need 1.8 mg a day and men need 2.3 mg a day of manganese.
Top natural sources of manganese:
1. Blue Mussels: 5.8 mg, 251% Daily Value (DV)
2. Hazelnuts: 1.8 mg, 76% DV
3. Pecans: 1.3 mg, 56% DV
4. Brown Rice: 1.1 mg, 47% DV
5. Pacific Oysters: 1 mg, 45% DV
6. Clams: 0.9 mg, 37% DV
7. Chickpeas: 0.8 mg, 37% DV
8. Spinach: 0.8 mg, 37% DV
9. Pineapple: 0.8 mg, 33% DV
10. Soybeans: 0.7 mg, 31% DV
11. Oatmeal: 0.7 mg, 30% DV
12. Whole-Wheat Bread: 0.7 mg, 30% DV
13. Black Tea: 0.5 mg 23% DV
14. Lentils: 0.5 mg, 21%
15. Banana: 0.4 mg, 16% DV
16. Baked Potato: 0.3 mg, 14% DV
https://www.livestrong.com/article/13769669-foods-high-in-manganese/
There was no way our diet was supplying this every day, and my multivitamins and multiminerals did not have it.
This is by far the most reckless article/study summary by med xpress I’ve read to date.
Amen! As a retired biophysicist/cardiovascular physiologist, I find my curmudgeon degree is supplanting the academic MSs and PhD.
Stupid ‘effing title. Medical Press might better have said “Gut reaction: Inadequate levels of manganese can aggravate inflammatory bowel disease” Otherwise, one might have assumed that a diet was exceeding a toxic concentration threshold, etc.
The Nature article was only a little more direct. The authors might have explicitly said in the discussion section what they alluded to in their Figure 9:
“Fig. 9 | Mn deficiency upregulates Acer1 expression and treatment with ACER1 inhibitor D-e-MAPP confers protection against colitis in Mn-deficient mice.”
As long as I’m on a rant - I think today I’d show about 1/3 of PhD and post-doc students to the door. Preparation and performance being inadequate.
Ohhh, the irony:
Keto warning: Low-carb, high-fat diets significantly boost diabetes risk
https://studyfinds.org/low-carb-diets-diabetes-risk/