Posted on 05/24/2024 10:07:22 AM PDT by ConservativeMind
A clinical trial has found that intravenous acetaminophen reduced sepsis patients' risk of having organ injury or developing acute respiratory distress syndrome.
Sepsis is the body's uncontrolled and extreme response to an infection. The researchers found that acetaminophen gave the greatest benefit to the patients most at risk for organ damage. With the therapy, those patients needed less assisted ventilation.
Limited research has suggested that acetaminophen might work better for patients with the most severe sepsis—those with higher levels of cell-free hemoglobin.
To test the therapeutic potential of acetaminophen more fully in a mid-stage clinical trial, researchers enrolled 447 adults with sepsis and respiratory or circulatory organ dysfunction at 40 U.S. academic hospitals from October 2021 to April 2023.
Patients were randomized to receive either acetaminophen or a placebo intravenously every six hours for five days.
The team's primary interest overall was the number of patients who were able to stay alive with no organ support, such as mechanical ventilation or kidney failure treatment.
The researchers found that intravenous acetaminophen was safe for all the sepsis patients, with no difference in liver injury, low blood pressure, or other adverse events compared to the placebo group. Among secondary outcomes, they also found that organ injury was significantly lower in the acetaminophen group, as was the rate of acute respiratory distress syndrome onset within seven days of hospital admission.
When looking more closely at the patients with higher cell-free hemoglobin, the researchers found that just 8% of patients in the acetaminophen group needed assisted ventilation compared to 23% of patients in the placebo group. And after 28 days, 12% of patients in the acetaminophen group had died, compared to 21% in the placebo group, though this finding was not statistically significant.
(Excerpt) Read more at medicalxpress.com ...
CDC and Gov. Whitmer to ban its use.
I don’t see how since acetaminophen destroys the pancreas.
Yes, and its crystalline makeup slowly chews up the liver.
That's hopeful...
They constantly try to jam this stuff down our throats, literally.
It’s in all kinds of OTC medications where you wouldn’t expect it.
There is no other OTC drug that has such a small margin between a therapeutic and a deadly dose.
Too much will wreck your liver. The only way to survive is to get a liver transplant.
Doesn’t high dose vitamin C IV solve sepsis
It really doesn’t “destroy the pancreas” but can cause pancreatitis that (usually) self-resolves.
It killed my mother.
And I’m on the same path.
Hereditary
Ok, that’s a little different. Very sorry to hear that.
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