Posted on 04/02/2024 10:07:55 PM PDT by ConservativeMind
Magnesium is a mineral critical to a wide range of biological functions, and a new study takes aim at how it's transported to address cardiac dysfunction and other diseases, opening new possibilities for treatment.
The study charts a new course in explaining how a novel protein called ERMA—a long-time mystery—functions as a precision-engineered pump in guiding magnesium.
The investigation reveals how disruptions in ERMA's function can lead to significant disturbances in how heart cells manage calcium, crucial for the rhythmic contractions of the heart muscle. These imbalances can lead to cardiac dysfunctions, particularly affecting the heart's relaxation phase and its ability to efficiently refill with blood.
"Our findings propose that targeting ERMA and its regulatory networks could open new therapeutic avenues for heart conditions, highlighting the critical need for precise magnesium management within heart cells to maintain a stable calcium balance," said Madesh Muniswamy, Ph.D., MS.
ERMA is an acronym for ER Mg2+ ATPase, with ER referring to the endoplasmic reticulum, or a network of membranes inside a cell through which proteins and other molecules move. It serves many roles in the cell including calcium storage, protein synthesis and lipid metabolism, and the new discovery reveals a magnesium reservoir.
Mg2+ represents magnesium ions and ATPase is an enzyme that converts stored chemical energies into mechanical actions within the cell.
Muniswamy said the new study sheds light on longstanding mysteries surrounding cellular magnesium transport, setting the stage for groundbreaking inquiries into implications for a wide range of diseases, with a particular focus on cardiac health.
(Excerpt) Read more at medicalxpress.com ...
This study speaks to finding out issues with magnesium and calcium create heart dysfunction, but you can make sure you do your part and make those minerals directly available to be used.
Up to 70% of people don’t get enough magnesium, and a lot don’t get enough calcium.
The involvement of the endoplasmic reticulum points toward protein synthesis, which magnesium plays a critical role in. As much as the present discovery is in the context of cardiac function, my guess is that many other systems are affected as well. Most notably, Alzheimer’s Disease involves misfolded proteins, with magnesium deficiency a common feature of the disease.
I don’t take calcium pills for fear of getting more deposits in my arteries. I don’t focus on calcium at all in my diet.
How do you get enough calcuim?
How much magnesium do you take in supplemental form?
Don’t get your magnesium at the same time as your calcium.
They bind together and pass through your intestines.
I take a supplement called “ZMA” from Biotest at night (zinc and magnesium). It’s highly bioavailabile. Milk in the morning.
If you take vitamin K and something called nattokinase you should not get any calcium deposits. In fact, mine reversed and went away after about 180 days.
how much natto and vitamin k do you take.
https://www.verywellhealth.com/what-is-nattokinase-89831
Interesting article. Natto, fermented soybeans, has some small studies so a lot of maybes right now. It breaks up blood clots and lowers blood pressure, maybe, but seems it may be of benefit.
I take one magnesium malate pill every day.
I only occasionally take a calcium pill, based roughly on how much calcium I got from food, coming down to if I had a meal with milk products of consequence.
I take a reasonable amount of vitamin K, so, at this point, I am not concerned about calcium being “misused.” Do note that it seems calcium plaques appear to be placed on soft plaques, unless on blood thinning agents like warfarin.
More here:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8066517/
If you take k2 everyday it pushes the calcium into your bones and away from your arteries. We take it everyday.
Whatever the Life Extension dosage is.
There are studies as to the dosage necessary, and I recall the pills being spot on.
Very Well Health is super conservative.
There are many more studies that back up the use of natto.
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