Posted on 03/20/2024 6:41:46 PM PDT by ConservativeMind
Fenoprofen, a nonsteroidal anti-inflammatory drug (NSAID), successfully alleviated pain and inflammation in a rodent model of endometriosis, according to researchers. They chose the drug after using a computer algorithm to evaluate nearly 1,300 existing compounds for their ability to reverse gene expression related to endometriosis disease.
Analysis by researchers using publicly available data from people with endometriosis, returned 299 candidate compounds with seven considered top candidates. These drugs included commonly used treatments for the disease, such as aspirin, as well as those not yet studied for this purpose. The researchers chose fenoprofen for further evaluation because it returned the highest gene expression reversal score and belongs to a drug class—NSAIDS—that is one of the first-line treatments for endometriosis.
Fenoprofen is a prescription drug approved for the relief of mild to moderate pain and is often prescribed for arthritis. The researchers analyzed electronic medical records from five University of California health care institutions and found that the drug had been prescribed for less than 1% of patients with endometriosis or related conditions. They then tested fenoprofen in a rodent model of the disease, observing that it successfully alleviated vaginal hyperalgesia, a surrogate marker for endometriosis-related pain.
(Excerpt) Read more at medicalxpress.com ...
“When testing fenoprofen in an established rat model of endometriosis, fenoprofen successfully alleviated endometriosis-associated vaginal hyperalgesia, a surrogate marker for endometriosis-related pain. These findings validate fenoprofen as a therapeutic that could be utilized more frequently for endometriosis.”
“We leverage a publicly available gene expression dataset of 105 endometriosis and healthy control samples which are further stratified into several comparisons: Control vs. all phases and all stages, Control vs. all stages stratified by menstrual phase, Control vs. Stage I-II or Stage III-IV for all menstrual phases. The resulting signatures are then queried against a collection of human cell lines treated with a number of therapeutic compounds for drugs that significantly reverse the disease associated expression. A candidate of interest is further validated in an animal model.”
In sum, they looked at over 3,100 genes and 299 drugs known to address those genes.
Again, from the paper:
“As fenoprofen had the highest reversal score of our drug candidates and belongs to a gold standard treatment category of drugs for endometriosis, our validation efforts herein were focused on this medication.”
Models may be of use in selecting drugs for actual trials. They are not the same as actual trials.
You’re not allowed to repurpose drugs. Remember ivermectin?
I’m not sure how they measure pain in animals.
Maybe if they jump out of their restraints and bite the lab tech in the thigh?
Think about it.
From the study:
They “used an established animal model of endometriosis that produces vaginal hyperalgesia, a surrogate marker for endometriosis-related pain. In this model, uterine pieces are autotransplanted onto mesenteric abdominal arteries. The uterine transplants develop over a period of weeks into cyst-like structures with characteristics similar to lesions in women with endometriosis.”
This same model has worked for many other endometriosis studies on therapies for humans.
Thumbs up!
Was thinking the same thing...
Bkmk
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