Posted on 03/12/2024 5:58:48 PM PDT by george76
Researchers have found a way to stop active cancer cells in their tracks – meaning they can then be eliminated by new drug treatments.
A collaborative research project between the University of Dundee’s Drug Discovery Unit (DDU) and Queen Mary University of London, has identified chemical compounds, called tool molecules, that can halt active cancer cells.
Advancing Cancer Therapy Through Collaboration..
Using these tool molecules forces tumor cells from a specific type of breast cancer into a pro-senescence state – similar to a sleep-like state in which they can no longer divide or cause tumor growth.
This condition makes the cancer cells sensitive to a second group of tool molecules, called senolytic drugs, which can eliminate them. It may also ‘uncloak’ the cancer cells, making them visible to the body’s immune system, offering further therapeutic opportunities.
Researchers developed this ‘two-punch’ method while looking at basal-like breast cancer (BLBC).
Potential for New Cancer Treatments..
A team funded by Barts Charity, and led by Cleo Bishop, Professor of Senescence at Queen Mary University of London and Academic Lead for the Phenotypic Screening Facility, uncovered a pathway to force BLBC cells into pro-senescence.
They then collaborated with another team based at the University of Dundee’s Drug Discovery Unit (DDU) to develop tool molecules to promote senescence within the cells.
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Drug treatments to deliver the ‘second punch’ of cell elimination are currently being developed elsewhere.
Professor Bishop, said, “At present, the most common treatments for BLBC are surgery and unsophisticated chemotherapy regimens.
“Consequently, the lack of possible targets for tailored therapies and the aggressive clinical course means that women with BLBC have a particularly poor prognosis.
“Pro-senescence therapies activate a stable cell cycle arrest halting tumor growth, trigger anti-tumor immune responses and expose cancers to novel treatment regimes called senolyitcs.”
This research utilized high-content imaging to identify the tool molecules from DDU’s diversity libraries, which have now been selected by the pharmaceutical company ValiRx for further evaluation.
The University of Dundee has this month signed a five-year agreement with the company, which focuses on early-stage cancer therapeutics and women’s health.
The pro-senescent ‘first punch’ tool molecules are the first to enter into a 12-month evaluation phase under this agreement and if successful, could result in a new company being established as a joint venture with all three parties.
Charlotte Green, Head of Business Development at the University of Dundee’s Drug Discovery Unit, said, “The one-two punch approach has gained lots of interest in recent years but currently there is no clinical precedent, by moving the project forward with ValiRx we are leading the way in translating the research to the clinic.”
Dr Suzy Dilly, CEO of ValiRx said, “The strength of the DDU and research facilities at Dundee are very impressive, and having reviewed multiple projects from teams there over the past year, we believe that this evaluation agreement will be the first of a series of new projects that can be brought into our pipeline.”
And this is the last we will ever hear of it.
Have to agree with you there. Seems like every time a new, promising therapy or cancer-killing drug comes up, away into the memory hole it goes!
. ?
The cure for cancer is on our grocery shelves. No money in the cure. All money is in diagnosis and treatment. Most of which don’t work. Big Pharma rules.
I live with my Cancer and hear of the newest “breakthrough” and shrug.
Sounds like good news. Hope it pans out.
After 10 Covid boosters, you will get the same result.(/S)
Baking soda, oranges, vitamin D...anything else?
Well, they want us to know they’re trying. Need that money, ya know.
I once read a book about medical researchers. It pretty much said curing cancer in a rat is pretty easy. Moving that to humans is where it gets difficult.
I read stuff like this and hope it works. But I am skeptical.
Did Joe cure cancer ALREADY???
What are we at, like 50 cures right now??
Bump
That can’t be. Joe Bribem said HE would cure cancer himself…
Big Pharma will never let it hit the market nor will they help make it, at least not for the masses. Maybe for the elite parasites of the world.
They want us dead, not living longer.
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