Posted on 12/17/2023 9:18:03 PM PST by ConservativeMind
Aging poses a number of challenges to the body's well-being, one of the most important being an increased susceptibility to multiple diseases, including urinary tract infections (UTIs). The connection between aging and more prevalent UTIs is not well understood, but now researchers have found an explanation.
Compared to the younger counterpart, the aging urinary tract in animal models changes how it functions at the cellular level in ways that seem to favor the establishment and recurrence of UTIs.
Furthermore, the researchers also found that the sugar D-mannose reduces the severity of aging-associated decline in urinary tract functionality, suggesting that this common, over-the-counter supplement could improve this age-associated dysfunction and help reduce UTIs.
"We began this study by comparing the functions of naturally aging cells in mouse bladders with those of younger animals," said Dr. Indira Mysorekar.
The researchers investigated a process called autophagy that all cells naturally use to clean up old or defective cellular materials by digesting and recycling them in structures called lysosomes. "We found that the recycling process naturally slows down as urothelial cells age," said Mysorekar.
"Older cells accumulate larger lysosomes that are less effective at degrading cellular materials, which leads to their toxic accumulation inside the cell."
Aged urothelial cells also accumulate more damaging reactive oxygen species (ROS) than younger tissues.
"Consequently, an inflammatory process builds up, leading to cell death. Dead urothelial cells leave their location, exfoliating the bladder and disrupting its integrity, which further exacerbates age-related dysfunction."
Importantly, they also discovered that treating aged mice with D-Mannose, a natural sugar, restores autophagy and mitigates ROS and urothelial cell shedding, suggesting that mannose supplementation could counter age-associated human urothelial dysfunction.
(Excerpt) Read more at medicalxpress.com ...
It appears to also reverse some aging issues with urothelial cells in the bladder, making them function properly, again.
Oh! The possible comments abound.
Does this mean that we can drink like we did in our 20's?
Did a beer distributor who recently tanked their sales by promoting wokism pay for this study in order to increase sales?
Is this related to manitol, the sweetener?
It only works for E. Coli, but as E. Coli accounts for over 90% of bladder infections, it’s a good bet. Multiple well-done studies in PubMed prove its efficacy. Anyone can look it up.
You can order the powder for cheap on Amazon. Mix with water, drink it down a half hour before breakfast every morning to prevent E. Coli UTIs. Worked very well for my elderly parents. But do stay vigilant for UTIs caused by less common bugs.
T/O
Interesting thread.
Thank you.
Merry Christmas. :)
Foods that contain it include cranberry, apple, orange, broccoli
Basically eat a varied diet with lots of fruits and veggies
I eat pretty healthy, so I should be getting my share of D-mannose. Yet I have had my share of UTI’s over the years. I can feel them coming on so a few days of Cranberry, D-mannose and Hibiscus supplements ALMOST always nips it in the bud. I probably should just do a maintenance dose a couple times a week.
Would cranberry, apple, and orange juice work too?
I get the brand by Superior Labs from Amazon. Two capsules in the morning, and one capsule at night. It has made a huge difference for me.
Thanks. Ordered.
I eat all of those! Except cranberries. yucch!.............
👍
Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.