Posted on 12/17/2023 8:24:14 PM PST by ConservativeMind
Research has revealed how, in diabetics, high levels of blood sugar disrupt the function of key cell subsets in the lungs that regulate the immune response. It also identifies a potential strategy for reversing this susceptibility and saving lives.
Prof. Eran Elinav's team subjected multiple mouse models of types 1 and 2 diabetes to a variety of viral lung infections. The immune reaction, which in nondiabetics eliminates the infection and drives tissue healing, was severely impaired in the diabetic mice, leading to uncontrolled infection, lung damage and eventual death.
"High blood sugar levels severely disrupt certain subsets of dendritic cells in the lung, preventing these gatekeepers from sending the molecular messages that activate the critically important immune response," says Nobs. "As a result, the infection rages on, uncontrolled."
Importantly, the scientists discovered how high sugar levels in diabetic mice disrupt the normal function of lung dendritic cells during infection. Altered sugar metabolism in these cells led to the accumulation of metabolic byproducts that markedly disrupted the normal regulation of gene expression, leading to aberrant immune protein production.
"This could explain why the functioning of these cells is disturbed in diabetes, and why the immune system is unable to generate an effective anti-infection defense," says Kolodziejczyk.
The scientists next explored ways to prevent the harmful effects of high sugar levels in lung dendritic cells, as a means of lowering the infection's risk in diabetic animals. Indeed, tight control of blood sugar levels by insulin supplementation prompted the dendritic cells to regain their capacity to generate a protective immune response that could prevent the cascade of events leading to a severe, life-threatening viral lung infection.
"Correcting blood sugar levels enabled our team to get the dendritic cells' function back to normal," says Abdeen.
(Excerpt) Read more at medicalxpress.com ...
Because of the dawn phenomenon, I don’t think Fasting BS is = to Waking BS.
That’s why a better benchmark is to test throughout the day over a variety of conditions (before meal, after meal, after no carbs at all, etc).
That’s why you should never do blood tests in the morning.
I've started the 5:2. 5 days, I do like you, but make sure I get in the normal 1700-2000 calories, then on the other two days, I just do 1 meal of 500-600 calories.
The key is to not do the same thing every day, so that your body doesn't adjust to it, eat at different times of the day, and vary the calories from day-to-day.
I also did a 72-hour water fast at the beginning of the month.
I hope to do the same at the beginning of every month.
After about 40 hours, I wasn’t even really hungry, I had to force myself to break the fast. And just eat a few small meals immediately after breaking a fast. You don’t want to get “Refeeding Syndrome” by eating a lot of carbs after breaking a fast.
Interesting, will keep that in mind.
I also try to do some light exercise (bench press, uphill walking/treadmill) Mon-Fri as the last thing I do in the late morning before my first meal.
One of the reasons it’s good to exercise in the morning is to burn off that Dawn Phenonmenon blood sugar, before it goes to fat, that’s why even before I did fasting I rarely ate before noon.
I’ve not heard of that before. Looking at the graphs, maybe I should exercise a little earlier.
Thanks.
Yes, a random BS test throughout the day, like Mayo Clinic explains in post 18.
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