Posted on 12/09/2023 11:04:30 AM PST by ConservativeMind
A study suggests a class of medications used to treat type 2 diabetes may also reduce the risk of colorectal cancer (CRC).
"Our results clearly demonstrate that GLP-1 RAs are significantly more effective than popular anti-diabetic drugs, such as Metformin or insulin, at preventing the development of CRC," said Nathan Berger.
Glucagon-like peptide-1 receptor agonists, or GLP-1 RAs, are medications to treat type 2 diabetes. Usually given by injection, they can lower blood-sugar levels, improve insulin sensitivity and help manage weight. They've also been shown to reduce the rates of major cardiovascular ailments.
Importantly the protective effect of GLP-1 RAs are noted in patients with or without overweight/obesity.
Nearly 75% of adults ages 20 or older in the United States are either overweight or obese, and nearly 20% of children and teens ages two to 19 have obesity, according to the NIH.
Since GLP-1 RAs have been shown to be effective anti-diabetic and weight-loss agents, the researchers hypothesized they might reduce incidence of CRC.
Using a national database of more than 100 million electronic health records, the researchers conducted a population-based study of more than 1.2 million patients. These individuals had been treated with anti-diabetic agents from 2005-19; the CWRU team examined the effects of GLP-1 RAs on their incidence of CRC, as compared to those prescribed other anti-diabetic drugs.
Among 22,572 patients with diabetes treated with insulin, there were 167 cases of CRC. Another 22,572 matched patients treated with GLP-1 RAs saw 94 cases of CRC. Those treated with GLP-1 RAs had a 44% reduction in incidence of CRC.
In a similar comparison of 18,518 patients with diabetes treated with Metformin, compared to 18,518 patients with diabetes treated with GLP-1 RAs, had a 25% reduction in CRC.
(Excerpt) Read more at medicalxpress.com ...
GLP-1 RA drugs = Trulicity, Ozempic, etc.
Oh, goody, here we go again. They’ve now targeted metformin and insulin for a cancer scare. The last time they started the craze about using a diebatic drug for something else it was Ozympic and now you can’t find it. I had to go to another drug and I pray the media doesn’t find out or they will be advertising it as a diet drug also.
I don’t use metformin anymore but it is the normal starting drug for low level diabetese and many start on it that need help. And insulin is way out of line as using it will place those in a lowering of their sugar numbers and they can go into diabetic shock. And if some think the doctors can moderate it you are talking about a drug that reacts to food intake from a previous day, rest, stress, and other illnesses tht trigger the other factors.
And just like Ozempic, it will be hard to find for those that are actual diabetics and need it to stay alive. Somebody is going to get killed.
wy69
There is something about these drugs that is amazing that clearly the bench geeks haven’t figured out. It’s like aspirin. Turing into a wonder drug.
Metformin is a pretty rough drug. Can get prettt ugly renal side effects if not careful. However, this far terzepitide and sister drugs only seem to carry the risk of MEN if you have a family history. It’s wayyyyy more endocrinologically active than we are giving it credit for is my thought.
Just like oncology, I think endocrine is coming into its golden age.
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They often cause diarrhea, so keeping the colon rather empty is probably the reason.
But the problem with this fixation of weight loss using drugs is further involved already. The example you used, for instance, tirzepatide, sold under the brand name Mounjaro among others, is an antidiabetic medication used for the treatment of type 2 diabetes and for weight loss cleared by the FDA in November this year.
But the MSDS on tirzepatide indicates they do not have data on the drug.
10. STABILITY AND REACTIVITY
10.1 Reactivity
No data available.
10.2 Chemical stability
Stable under recommended storage conditions.
10.3 Possibility of hazardous reactions
No data available.
10.4 Conditions to avoid
No data available.
10.5 Incompatible materials
Strong acids/alkalis, strong oxidising/reducing agents.
10.6 Hazardous decomposition products
Under fire conditions, may decompose and emit toxic fumes.
Other decomposition products - no data available.
11. TOXICOLOGICAL INFORMATION
11.1 Information on toxicological effects
The toxicological effects of this product have not been thoroughly studied.
“https://www.abmole.com/literature/tirzepatide-tfa-msds.html“>https://www.abmole.com/literature/tirzepatide-tfa-msds.html
So there is a lot up in the air about this flooding of weight loss products into the public as a lot of them may or may not be compatible. And we have to face the idea that all dogs are not alike. So how each person is going to tolerate the drugs has numerous possibilities.
wy69
Actually tirzepitide causes constipation. Also seems to delay gastric emptying somewhat as well
I, and at least one other person I know, am on tirzepitide. It causes horrible diarrhea, especially for the first several weeks.
Fair enough. Most report constipation. I know a lot of nurses who started using it at a high dose and it made them miserable. Starting low and escalating to optimum appetite control seems to be the best path. A loading dose seems to be misery inducing.
True that. I was on the maximum dose of Metformin for at least six years until docs realized I was ruining my kidneys. Now off it completely and using insulin. I never got used to the smell of the drug.
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