Posted on 11/23/2023 1:07:43 PM PST by ConservativeMind
Researchers have now revealed that vitamin B12 plays a pivotal role in cellular reprogramming and tissue regeneration.
The research was focused on an experimental process known as cellular reprogramming which is thought to mimic the early phases of tissue repair. The team found that cellular reprogramming in mice consumes large amounts of vitamin B12. Indeed, the depletion of vitamin B12 becomes a limiting factor that delays and impairs some aspects of the reprogramming process.
The researchers validated their findings in a model of ulcerative colitis, demonstrating that the intestinal cells initiating repair undergo a process similar to cellular reprogramming and also benefit from vitamin B12 supplementation. Patients with intestinal bowel disease could potentially benefit from vitamin B12 supplementation.
In this study, the researchers delved into the metabolic requirements of cellular reprogramming and found that vitamin B12 is a limiting factor for a particular branch of metabolism involved in a reaction known as methylation. Precisely, the DNA of the cells initiating reprogramming or tissue repair require very high levels of this methylation reaction and therefore of vitamin B12.
The researchers discovered that vitamin B12 insufficiency during reprogramming or tissue repair resulted in significant epigenetic changes, leading to errors in the function of multiple genes.
"Supplementation with vitamin B12 corrected this imbalance, resulting in enhanced gene function fidelity and overall improved reprogramming efficiency," confirms Dr. Marta Kovatcheva.
Another study concluded that people with higher levels of vitamin B12 in blood had lower levels of inflammatory markers (IL-6 and CRP).
The researchers also observed a similar relationship in aged mice. These observations suggest that vitamin B12 exerts anti-inflammatory action by reducing these markers in the body and they provide valuable insights into the potential health benefits of vitamin B12.
(Excerpt) Read more at medicalxpress.com ...
Eat red meat for B-12. I love beef, any cut, fixed any way.
My doc diagnosed me as low on B-12 many years ago. I’ve been on supplants for a long time, first daily, then every other day and finally every third day to get blood concentrations right.
Very interesting that it reduces inflammation markers. Does it just reduce the markers? Or does it actually reduce inflammation? Wouldn’t that be important for heart and artery health?
We take it everyday.
Way too much fat and calories in red meat, B-12 is the only suppliment I take
How much in one pill? How much is enough?
I knew a woman that got B12 shots long long ago.
bump for reference
There are a variety of issues with B12. Many depend on your genetic engineering.
You have to do trial and error.
In the US they use the B12 shot that has cyanide in it. What I needed was the version used in Europe that has been broken down somewhat
https://www.mcpiqojournal.org/article/S2542-4548(19)30033-5/fulltext
If you have had a path review done on a CBC you can look for signs of a B12 issues. Hypersegmented neutrophils. But don’t expect your primary care physician to know jack about any of it
The vitamin supplement I take has, according to the label, 4167% of recommended daily allowance.
The vitamin supplement I take has, according to the label, 4167% of recommended daily allowance.
Thank you. He wouldn’t for sure. He’d send me to a specialist and charge me for asking.
Very interesting on the CRP, I’ve been using B Complex that has a high B12 RDA. Giving blood on 30th to check my CRP levels.
In this study, the researchers delved into the metabolic requirements of cellular reprogramming and found that vitamin B12 is a limiting factor for a particular branch of metabolism involved in a reaction known as methylation. Precisely, the DNA of the cells initiating reprogramming or tissue repair require very high levels of this methylation reaction and therefore of vitamin B12.
The researchers discovered that vitamin B12 insufficiency during reprogramming or tissue repair resulted in significant epigenetic changes, leading to errors in the function of multiple genes.
This is exactly what Randy Jirtle discovered using agouti mice here at Duke University many years ago.
“In Jirtle’s experiment, DNA methylation at the agouti gene sites was decreased by 31%. (DNA methylation was reduced on other genes as well.) These results supported the hypothesis that bisphenol A alters the action of organisms’ epigenomes by removing methyl groups from DNA.
When scientists fed pregnant yellow mice diets rich in nutrients containing methyl-groups, like folic acid and vitamin B12, the agouti gene in pups got switched off. The pups from such mice were brown and thin, not fat and yellow.”
B-12 is destroyed in the stomach by acids if the parietal cells in the stomach do not produce enough intrinsic factor.
This is why many elderly get B-12 shots to bypass the stomach.
I’ve read that Vitamin C and B12 also do not get along and should not be taken together, but 3 hours apart. I’ve also seen that Calcium, Magnesium and Zinc should not be taken together yet I see supplements all over stores that contain just these three vitamins together. Drive a man nuts trying to figure this all out.
For years I had the blahs, no energy or willingness to be as I was.
I learned that I needed some B12. A drug was inhibiting B 12 asbsorption. began to take a 5000 unit dissolvable tablet every morning. The result and ensuing change was just amazing.
I had a condition called neuropathy manifested as numbness in my left leg. Taking a B 12 tablet at bed time solved that problem.
I now take a lot of B12, 7,000 units I think. I feel better than I have in years and do stuff I formerly did not because I didn’t give a dam.
B 12 is a thriving industry. One guy sells small bottles of energy supplement for $3 or so a pop. Red Bull and M are energy drinks and expensive. Both are largely B 12. The same results can be obtained by taking say 1,000 unit B 12 tablet that is very cheap
Over 50 years ago my gynechologist was concerned about my anemia. He kept prescribing iron, but the anemia did not change much. Then I read in an Adelle Davis book that in anemia, sometimes the red blood cells (RBC) did not live as long as they should. She recommended taking Vitamin E saying that RBC life spans could increase from something like 85 days to 115 days. I started taking Vitamin E and in a few months my anemia was normalized. I still take Vitamin E and my anemia is atill absent.
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