Clinical trial suggests fecal transplants may protect transplant patients against multi-drug-resistant organisms

Medical Xpress / Science Translational Medicine ^ | Nov. 2, 2023 | Bob Yirka / Michael H. Woodworth et al

[ConservativeMind]

A team of infectious disease researchers has found via clinical trial that fecal transplants after kidney transplantation reduce the susceptibility of patients to infections by multi-drug-resistant organisms (MDROs).

In their study, the group tested the impact of fecal microbiota transfer (FMT) on kidney transplant patients receiving care at Emory Transplant Center, in Atlanta.

Prior research has shown that people who receive kidney transplantation are at risk of developing an infection from MDROs. This is because patients are given antibiotics to prevent general infections, killing all non-drug-resistant organisms. The absence of competing organisms allows MDROs to flourish, putting these patients at serious risk. In this new effort, the researchers tested giving kidney transplant patients FMTs as a way to reduce the risk of MDRO infections.

The test was conducted in the form of a phase I clinical trial involving 11 patients who underwent kidney transplants. In addition to a new kidney, each patient also received an FMT via enema. Stool samples were tested every day for 36 days following their surgery. The research team notes that they chose the enema method of FMT for the trial because it has the lowest chance of introducing undesired organisms to the gut biota. The researchers also gave some of the patients a second FMT if they continued to show high levels of MDROs.

The researchers found significant results in most of the patients—eight of the patients who had contracted an MDRO infection tested negative for it after 36 days. The research team also conducted a genetic analysis of stool samples from the patients in the trial and found evidence of reduced numbers of MDROs. They conclude that the FMT procedure works because it forces MDROs to compete for resources inside the gut biome.

[ConservativeMind]

It appears eight of the eleven transplant recipients got an infection by multi-drug-resistant bacteria, but were cured by the fecal transplant taking hold.

If this understanding is correct, that was a 73% remediation rate, effectively from the fecal transplant, but initially caused by the mass antibiotics given, to “reduce” bacterial problems.

We can create bizarre issues, when trying to do well, for others. You do need to get rid of pathogenic concerns, but then you can have some remain that cause further problems.

[ConservativeMind]

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[Red Badger]

No sh!t?.........

[dfwgator]

So Your Mom Had a Fecal Transplant
https://www.youtube.com/watch?v=mCyE6Db3miE

[aimhigh]

I’ve read about three multiple sclerosis patients that were healed and restored to walking, as the result of fecal transplants.

I read an article about a slender mother who became obese after getting a fecal transplant from her obese daughter.

More research needed. Problem is, there is no big pharma $$ to be had.

[ConservativeMind]

Gut bacteria have outsized impacts on us.

[Tea Drinker]

I know a woman from the Pilates studio I attend who has Parkinson’s. She doctors with a specialist from MD Anderson in Houston who talked to her about fecal transplants.