Posted on 10/18/2023 8:30:59 PM PDT by ConservativeMind
A team of reproductive biologists has found that spermidine, a polyamine metabolite, helps oocytes clear away damaged mitochondria in mice, thereby improving mitophagy during female reproductive aging.
Prior research and anecdotal evidence have shown that many animals experience declining fertility as they grow older. In this new effort, the research team found a link between spermidine levels in aging mice and fertility issues.
The researchers began by measuring spermidine levels in ovarian tissue samples of mice of different ages—they found that as the mice grew older, their levels of spermidine were reduced. They also noted that the quality of oocytes and follicles fell.
To see if such effects might be reversed, they injected some of the test mice with spermidine, which prevented the degradation of the oocytes and follicles—they also found that giving mice water containing spermidine did the same thing. Taking a longer look, they found that giving test mice spermidine also improved the success rate of blastocysts and resulted in more litters produced in later years than in a control group.
To find out why giving the mice spermidine improved their fertility, the team took a closer look at oocyte cells. They found that as the mice grew older, damaged mitochondria were not cleared away as well as in younger mice. They sequenced the cells' RNA and found different expression patterns from genes between young and older mice. They also found that mice given spermidine did not lose their ability to clear away damaged mitochondria, and in fact, saw enhanced mitochondrial function. The researchers found similar effects when they gave pigs spermidine.
The research team suggests the possibility of using spermidine as a therapy for promoting fertility in women who experience problems getting pregnant as they get older.
(Excerpt) Read more at medicalxpress.com ...
I am willing to give it away for free.
What does Spider-Man have to do with this?
I’m just here for the comments...
What a charitable soul you are Jonty! LOL!
Earth Elixir Spermidine is one brand.
Maybe ‘e licks her spermidine, but not me! I think there’s a video of that on the internet somewhere.
$49.99 per bottle plus shipping and handling.
Mitophagy is probably highly helpful to slow aging in most/all cells, not just oocytes.
breeding is for the young people....be fruitful and multiply...that is nature’s way but we humans have even “screwed” that up by not producing offspring and yet its all the rage to have viagra and breast enhancements when people are too old for active parenting..
Out of the brans I saw, Double Wood is the one I’d pick.
That is, “brands.”
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