Scientists reveal mechanistic link between zinc levels and diabetes (Zinc helps fatty liver and diabetes)

Medical Xpress / eLife ^ | Sept. 25, 2023 | Shek Man Chim et al

[ConservativeMind]

Researchers have identified a mechanistic link between zinc levels in humans and the risk of type 2 diabetes and fatty liver disease.

Converging lines of evidence have shown that zinc plays a crucial role in insulin production and glucose metabolism. "We know that increasing zinc intake improves blood glucose control in people with prediabetes or type 2 diabetes, and people with a mutation in a key zinc transporter protein have reduced risk of diabetes." says Shek Man Chim.

Chim and colleagues identified a mutation called SLC39A5, associated with increased circulating zinc levels.

The team explored its function by genetically engineering mice lacking the zinc transporter protein. As anticipated, these mice had elevated blood and tissue levels of zinc. When the team fed mice a high-fat, high-fructose diet to induce obesity, there was a significant reduction in fasting glucose compared to the control mice fed the same diet. Similar results were observed in a congenital (leptin receptor-deficiency) model of obesity. Loss of SLC39A5 also resulted in reduced insulin resistance—a hallmark of diabetes where tissues fail to respond to insulin signals trying to trigger glucose uptake from the blood.

Given that diabetes often coincides with non-alcoholic fatty liver disease, the team explored whether loss of SLC39A5 protects the liver, too. As hoped, mice lacking SLC39A5 had less build-up of fat in the liver and in blood markers of liver damage. Moreover, mice lacking SLC39A5 but fed a high-fat, high-fructose diet also had less fat accumulation in the liver and improved insulin sensitivity compared to control mice.

The mice lacking SLC39A5 had reduced liver damage markers, fasting blood glucose and improvements in liver inflammation and fibrosis.

"Our observations suggest that blocking SLC39A5 could be a potential therapeutic avenue for type 2 diabetes and other indications where zinc supplementation alone is inadequate."

[gleeaikin]

I just bought a tube of apple flavor horse IVM at a farm equipment store in West Virginia. It says use for up to a 1250 lb. horse. As a 135 lb woman should I use about 1 9th of a tube for treatment of covid, and also for how many days. I would also be using zinc and a number of other supplements I have been using since before Covid.

The clerk made a point of warning me this was only for use on horses. I was recently treated for Lymes Disease with Doxycycline after I had a bloody tick on my back and a red circle around it about 2 inches in diameter. At a recent conference someone was saying something about IVM and Lymes, but I did not hear the details. Anyone here know more??

[Non-Compliant_Deplorable]

I found a number of studies indicating that IVM treats Lyme disease. Here’s a link to the search results:

https://presearch.com/search?q=%22lyme+disease%22+ivermectin

Also, if you’re going to be taking it over an extended period of time, pill form IVM might be easier for dosing. Here’s a link to a list of reliable places to buy it, no Rx required (posted over at Patriots.win):

https://patriots.win/p/17r9Rj8cNU/places-to-buy-ivermectin—hcq-an/

NOTE: A link to a list of Protocols for use / dose is at the top of the landing page.

[KittyKares]

Do you happen to know which is the best type of zinc to get for viruses? E.g., zinc gluconate, zinc picolinate, chelated zinc, etc., or does it matter?