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After treatment with semaglutide, newly diagnosed type 1 diabetes patients found to need little or no insulin
Medical Xpress / University at Buffalo / New England Journal of Medicine ^ | Sept. 6, 2023 | Paresh Dandona, MD, Ph.D. et al

Posted on 09/10/2023 8:31:23 PM PDT by ConservativeMind

Treating newly diagnosed type 1 diabetes patients with semaglutide (trade names Ozempic, Wegovy and Rybelsus) may drastically reduce or even eliminate their need for injected insulin.

Those are the remarkable findings of a small study.

"Our findings from this admittedly small study are, nevertheless, so promising for newly diagnosed type 1 diabetes patients that we are now absolutely focused on pursuing a larger study for a longer period of time," says Paresh Dandona, MD, Ph.D.

A total of 10 patients were studied, all of whom had been diagnosed in the past three to six months with type 1 diabetes. The mean HbA1c level (an individual's average blood sugar level over 90 days) at diagnosis was 11.7, far above the American Diabetes Association's HbA1c recommendation of 7 or below.

The patients were treated first with a low dose of semaglutide while also taking meal-time (bolus) insulin and basal (background) insulin. As the study continued, semaglutide dosing was increased while mealtime insulin was reduced in order to avoid hypoglycemia.

"Within three months, we were able to eliminate all of the mealtime insulin doses for all of the patients," says Dandona, "and within six months we were able to eliminate basal insulin in 7 of the 10 patients. This was maintained until the end of the 12-month follow-up period."

During that time, the patients' mean HbA1c fell to 5.9 at six months and 5.7 at 12 months.

"We found that a significant proportion of such diabetics still have some insulin reserve in the beta cells of their pancreas," Dandona explains. "This reserve is most impressive at the time of diagnosis, when 50% of the capacity is still present. This allowed us to hypothesize that semaglutide, which works through stimulation of insulin secretion from the beta cell, could potentially replace mealtime insulin administration."

(Excerpt) Read more at medicalxpress.com ...


TOPICS: Health/Medicine
KEYWORDS: diabetes; diabetic; medicalxpress; ozempic; rybelsus; semaglutide; type1diabetes; typeonediabetes; wegovy
Type 1 diabetes was largely, or completely, mitigated, using semaglutide in a timely fashion, upon diagnosis.
1 posted on 09/10/2023 8:31:23 PM PDT by ConservativeMind
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To: Mazey; ckilmer; goodnesswins; Jane Long; BusterDog; jy8z; ProtectOurFreedom; matthew fuller; ...

The “Take Charge Of Your Health” Ping List

This high volume ping list is for health articles and studies which describe something you or your doctor, when informed, may be able to immediately implement for your benefit.

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2 posted on 09/10/2023 8:32:01 PM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind

I smell faked results. Now who would have the incentive to release results of such a small (and statistically invalid) test result?
I wonder, I wonder, I do wonder.


3 posted on 09/10/2023 8:35:19 PM PDT by Honest Nigerian
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To: ConservativeMind

Since Type Ones are not producing ANY insulin naturally, I can’t see how this is possible.

(Type 2 myself for almost 25 years, so I’m pretty much up on the whole business.)


4 posted on 09/10/2023 8:40:47 PM PDT by Chad C. Mulligan
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To: ConservativeMind

>”Within three months, we were able to eliminate all of the mealtime insulin doses for all of the patients,” says Dandona, “and within six months we were able to eliminate basal insulin in 7 of the 10 patients”

Guessing that the stuff mitigates autoimmune anti islet cell response? Is it actually that slow of a process?


5 posted on 09/10/2023 8:54:37 PM PDT by struggle
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To: Chad C. Mulligan

Maybe because you, like everyone else, don’t know everything, and you just accept what the conventional medical establishment tells you.

Read this:

https://www.med.uio.no/klinmed/english/research/news-and-events/news/2015/regain-ability-insulin.html


6 posted on 09/10/2023 8:55:57 PM PDT by Secret Agent Man (Gone Galt; not averse to Going Bronson.)
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To: Chad C. Mulligan

Also this:

Type 1 diabetes: Almost half of patients produce insulin

https://www.medicalnewstoday.com/articles/318094


7 posted on 09/10/2023 8:57:15 PM PDT by Secret Agent Man (Gone Galt; not averse to Going Bronson.)
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To: Honest Nigerian

“I smell faked results.”

ditto ... Type 1 is an autoimmune disease that has destroyed the insulin-producing Islets of Langerhans in the Pancreas ...


8 posted on 09/10/2023 9:33:12 PM PDT by catnipman (In a post-covid world, ALL "science" is now political science: stolen elections have consequences)
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To: Secret Agent Man

Type 1 diabetes: Almost half of patients produce insulin

In which case they’re Type 2, no?


9 posted on 09/10/2023 10:05:55 PM PDT by Chad C. Mulligan
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To: Chad C. Mulligan

You don’t read very well. The medical folks who wrote this are clear in what they are saying. Go argue with them, I am sure they will bow to your greater intelligence on the subject.


10 posted on 09/10/2023 10:43:23 PM PDT by Secret Agent Man (Gone Galt; not averse to Going Bronson.)
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To: Secret Agent Man
I really hate when an article says almost half, when the study had 113 participants.

The actual study says "Approximately 40% of the investigated patients with type 1 diabetes and ≥10 years duration of disease had measurable fasting C-peptide concentrations"

That also stinks.

the number of participants(113) that were producing some insulin was 46 for 40.7%.(I guess that's almost half{s/off}

The interesting study here:(see table 1 for the numbers) No explanation for why Type 1s produce insulin and a lot of hypothoses

https://diabetesjournals.org/care/article/40/8/1090/36752/Increased-Interleukin-35-Levels-in-Patients-With
11 posted on 09/10/2023 11:21:25 PM PDT by stylin19a (The #1 Golf rule you MUST follow: take car keys out of golf bag before throwing it into the creek)
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To: stylin19a

I think its clear that some pancreatic cells simply are not 100% burned out.

Type 1 is a diagnosis we make, it doesnt mean everyone who gets diagnosed as Type 1 is identical in pancreatic damage, and also this finding may mean our current definition of Type 1 isn’t scentifically correct. Because while they appear to not produce any insulin, in reality they may be producing a very small amount, but in such small amounts it either isn’t measurable, or is so small its used up extremely fast and therefore, again, not really measurable by typically-given tests.


12 posted on 09/10/2023 11:56:58 PM PDT by Secret Agent Man (Gone Galt; not averse to Going Bronson.)
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To: ConservativeMind

Interesting. Too late for me.


13 posted on 09/11/2023 5:16:09 AM PDT by NetAddicted (MAGA2024)
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To: Secret Agent Man

Well said!


14 posted on 09/11/2023 10:20:38 AM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind

So, for $1,500 a month you too can be cured.


15 posted on 09/12/2023 9:15:07 AM PDT by Sequoyah101 (Procrastination is just a form of defiance)
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