Posted on 09/05/2023 3:02:08 PM PDT by ConservativeMind
A collaboration between researchers has looked into the efficacy and safety of psilocybin in patients with major depressive disorder.
In a paper, the team finds a rapid onset of antidepressant effects, sustained reduction in depressive symptoms, and improvement in psychosocial functioning associated with a single 25mg dose of psilocybin administered with psychological support in patients with major depressive disorder (MDD).
A randomized, double-blind, placebo-controlled, phase 2 trial was conducted at 11 research sites in the US between December 2019 and June 2022. It involved 104 adults diagnosed with MDD with moderate or greater symptom severity.
Participants received either a single 25mg dose of psilocybin or a 100mg dose of niacin (placebo control) alongside psychological support. Primary and secondary outcomes were assessed at various time points up to 43 days after dosing.
Psilocybin treatment was associated with a significant reduction in Montgomery-Asberg Depression Rating Scale (MADRS) scores compared to niacin from baseline to day eight and baseline to day 43.
Psilocybin treatment also significantly reduced Sheehan Disability Scale (SDS) scores compared to niacin from baseline to day 43.
Exploratory outcomes included scores on the Clinical Global Impressions Scale, Hamilton Anxiety Rating Scale, Quality of Life Enjoyment and Satisfaction Questionnaire, Symptoms of Major Depressive Disorder Scale, and the Oxford Depression Questionnaire (to assess emotional blunting).
The study found that psilocybin treatment was associated with improvements in these exploratory outcomes, including reductions in global disease severity, self-reported depressive and anxiety symptoms, and improved quality of life. Psilocybin treatment did not lead to emotional blunting, often a side effect of standard antidepressant medications.
The study suggests that psilocybin treatment positively impacted various aspects of mental health and well-being beyond just reducing depressive symptoms, as it improved overall functioning, anxiety symptoms, and quality of life in the study participants.
(Excerpt) Read more at medicalxpress.com ...
To paraphrase Mr. Natural.
Still the best.
https://www.youtube.com/watch?v=xLJRQQ7ITHA
Get on board, reaper wants to take y’all for a ride!
His private train is leavin’, slip you to the other side
He got, cocaine and morphine too.
Lots o’ stuff to get y’all high!
Little pink pills in a big brown bag.
Truckin off across the sky.
I thought while we were at it, We might study for a bit Thermo Dynamics, specifically “Vertical and adiabatic ionization energy in molecules. Later.
Frankly the Army Chemical Corps, workers at Fort Dietrich in the nineteen fifties, and the CIA knew this a long long time ago.
DO NOT TAKE THE BROWN ACID!..................
Abbie Hoffman?..........................
Yeah, I know. I was just making a fun comparison.
He lived to 102!...................Abbie Hoffman committed suicide.......
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