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Treatment decisions in new era of individualized therapy for metastatic hormone-sensitive prostate cancer
Medical Xpress / Dana-Farber Cancer Institute / Journal of Clinical Oncology ^ | June 9, 2023 | Jeremiah Wala et al

Posted on 06/13/2023 7:16:57 AM PDT by ConservativeMind

Oncologists have traditionally prescribed androgen deprivation therapy (ADT) alone for patients with metastatic hormone-sensitive prostate cancer (mHSPC).

Now, there are many possible treatment options. Clinical trials have shown that more aggressive up-front treatment with a range of combination therapies improves outcomes. This case study shows how Dana-Farber Cancer Institute oncologists interpreted the evidence from these trials and applied it to an individual patient with mHSPC.

The researchers recommend aggressive up-front treatment with triplet therapy (ADT, an androgen-receptor pathway inhibitor, and chemotherapy) for patients who can tolerate chemotherapy, and especially for patients with high-volume disease. For patients with low-volume disease, they recommend adding radiation therapy if feasible.

The researchers also recommend the use of PSMA-PET scans to find metastases, evaluate treatment response, and identify potential sites for radiation.

Choosing a treatment approach requires interpretation of the results of many trials and the consideration of multiple factors unique to each patient. This case study provides that interpretation and gives evidence-based guidance for how to navigate decision-making for individual patients.

(Excerpt) Read more at medicalxpress.com ...


TOPICS: Health/Medicine
KEYWORDS: cancer; prostate
After reviewing the issues around metastatic hormone-sensitive prostate cancer, these oncologists say it’s best to throw everything at it, all at once.
1 posted on 06/13/2023 7:16:57 AM PDT by ConservativeMind
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To: Mazey; ckilmer; goodnesswins; Jane Long; BusterDog; jy8z; ProtectOurFreedom; matthew fuller; ...

The “Take Charge Of Your Health” Ping List

This high volume ping list is for health articles and studies which describe something you or your doctor, when informed, may be able to immediately implement for your benefit.

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2 posted on 06/13/2023 7:17:35 AM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind

I survived prostate cancer found in Sept 2012 early as stage 1C. I had the traditional seeds and 35 days of radiation. My PSA never went higher than 4.2 but had doubled from it’s usual 2 so my alert MD sent me to a urologist for a biopsy. The biopsy was very uncomfortable but worth the time and trouble obviously. Praising God for success.


3 posted on 06/13/2023 8:05:18 AM PDT by Midwesterner53
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To: Midwesterner53

Congratulations!


4 posted on 06/13/2023 8:08:25 AM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind

20 year survivor here on ADT + an androgen-receptor pathway inhibitor. Expect to get off these after nine months, and start another “vacation”.


5 posted on 06/13/2023 8:41:46 AM PDT by cicero2k
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To: cicero2k

Excellent! That is encouraging to hear.

All men are expected to get prostate cancer, if we live long enough, and success stories like yours provide hope.


6 posted on 06/13/2023 8:59:33 AM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: cicero2k

Were you dx’d with metastases 20 years ago? If so, outstanding and congratulations!


7 posted on 06/13/2023 2:57:07 PM PDT by Magic Fingers (Political correctness mutates in order to remain virulent.)
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