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Dissolution of Spike Protein by Nattokinase Holy Grail of COVID-19 Vaccine Detoxification
PETER A. MCCULLOUGH ^ | FEB 21, 2023 | PETER A. MCCULLOUGH, MD, MPH™

Posted on 05/31/2023 7:28:50 AM PDT by dennisw

By Peter A. McCullough, MD, MPH

Far and away the most common question I get from those who took one of the COVID-19 vaccines is: “how do I get this out of my body.” The mRNA and adenoviral DNA products were rolled out with no idea on how or when the body would ever breakdown the genetic code. The synthetic mRNA carried on lipid nanoparticles appears to be resistant to breakdown by human ribonucleases by design so the product would be long-lasting and produce the protein product of interest for a considerable time period. This would be an advantage for a normal human protein being replaced in a rare genetic deficiency state (e.g. alpha galactosidase in Fabry’s disease). However, it is a big problem when the protein is the pathogenic SARS-CoV-2 Spike. The adenoviral DNA (Janssen) should broken down by deoxyribonuclease, however this has not be exhaustively studied.

This leaves dissolution of Spike protein as a therapeutic goal for the vaccine injured. With the respiratory infection, Spike is processed and activated by cellular proteases including transmembrane serine protein 2 (TMPRSS2), cathepsin, and furin. With vaccination, these systems may be avoided by systemic administration and production of Spike protein within cells. As a result, the pathogenesis of vaccine injury syndromes is believed to be driven by accumulation of Spike protein in cells, tissues, and organs.

Nattokinase is an enzyme is produced by fermenting soybeans with bacteria Bacillus subtilis var. natto and has been available as an oral supplement. It degrades fibrinogen, factor VII, cytokines, and factor VIII and has been studied for its cardiovascular benefits. Out of all the available therapies I have used in my practice and among all the proposed detoxification agents, I believe nattokinase and related peptides hold the greatest promise for patients at this time.

Tanikawa et al examined the effect of nattokinase on the Spike protein of SARS-CoV-2. In the first experiment they demonstrated that Spike was degraded in a time and dose dependent manner in a cell lysate preparation that could be analogous to a vaccine recipient. The second experiment demonstrated that nattokinase degraded the Spike protein in SARS-CoV-2 infected cells. This reproduced a similar study done by Oba and colleagues in 2021.

Nattokinase is dosed in fibrinolytic units (FU) per gram and can vary according to purity. Kurosawa and colleagues have shown in humans that after a single oral dose of 2000 FU D-dimer concentrations at 6, and 8 hours, and blood fibrin/fibrinogen degradation products at 4 hours after administration elevated significantly (p < 0.05, respectively). Thus an empiric starting dose could be 2000 FU twice a day. Full pharmacokinetic and pharmacodynamic studies have not been completed, but several years of market use as an over-the-counter supplement suggests nattokinase is safe with the main caveat being excessive bleeding and cautions with concurrent antiplatelet and anticoagulant drugs.

Based on these findings, nattokinase and similar products such as serrapeptase should undergo well-funded, accelerated preclinical and clinical development programs. The issue at hand is the urgency of time, similar to that with SARS-CoV-2 infection and empiric early therapy. It will take up to 20 years to have a fully developed pharmaceutical profile to characterize the safety and efficacy of nattokinase in the treatment of vaccine injury and post-COVID syndromes. Large number of people are sick now and many believe empiric treatment is justified given sufficiently low risk of side effects and potentially high reward. My recommendation is to discuss this with your doctor or seek a specialist in holistic or naturopathic medicine who is experienced with the safety profile of nattokinase in a range of applications.


TOPICS: Health/Medicine
KEYWORDS: covid; covidvaccine
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To: YouGoTexasGirl

100%


21 posted on 05/31/2023 9:12:10 AM PDT by ConservativeDude
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To: rx

Yeah, that ain’t right. We are never to busy to swear you in. Do you want us to skip over your next promotion because we are busy?


22 posted on 05/31/2023 9:13:00 AM PDT by Delta 21 (MAGA Republican is my pronoun.)
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To: Deepeasttx

Yes, she had 2 stents placed last summer. She has been doing great, but the bruising is awful. I know they will never agree to put her on Nattokinase, since there are no studies on it, but if I could convince them To step back the dose and replace with aspirin, she wants to try the Nattokinase. She’s just afraid to take it while on Plavix.


23 posted on 05/31/2023 9:32:31 AM PDT by ponygirl (An Appeal to Heaven)
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To: rx

Don’t forget how Nancy Pelosi so carefully worded that signed document claiming she had seen Ovomit’s “birth certificate.”


24 posted on 05/31/2023 9:36:06 AM PDT by ponygirl (An Appeal to Heaven)
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To: Cold Heart

My brother took the J&J and now has sciatica that is not responding to injections. He has also had personality changes and flies into unprovoked rages…could be due to pain or to changes in the brain due to the shot, but I stay away from him.


25 posted on 05/31/2023 9:43:54 AM PDT by ponygirl (An Appeal to Heaven)
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To: dennisw

Thx for this post. All family vaxxed. Not me or my wife.

But we got the omicron in 6/2022.

One thing not discussed. Covid was designed to kill people. The vaxx might have been Stage 2 maybe to finish the job.

Sorry think I’m dying .

Fauci chose Corona because they could’nt vaxx it.

He tried to vax Aides for 35 years - and failed. Only the Aides cocktail helped. Not his project.

More later. Maybe.


26 posted on 05/31/2023 10:08:51 AM PDT by Tunehead54 (Nothing funny here ;-)
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To: dennisw; ConservativeDude; Tilted Irish Kilt; null and void; SeekAndFind; ConservativeMind; ...

After recovering from 3 months of persistent respiratory illness, I have been doing a deep dive in Covid vaccine matters. I have come to several conclusions and conjectures.

1) What is the common pattern in all or several vaccines that causes serious and long term problems.

2) The best explanation I have seen so far for these problems may be found in the IgG portion of our immune system. After multiple Covid shots there appears to be a derangement in the ratios/percentages of the 1 thru 4 components of the IgG system. Best virus fighter IgG3 disappears after 3 shots, while IgG4 becomes an ever higher percentage of the total IgG immune component, but also looses interest in fighting the target virus (in this case Covid).

3) Based on personal experience doses of 10 or more grams of Vitamin C spaced out over the day can help illness, and it is important to have a good Vitamin D blood level. THis based on the fact my D level dropped from optimum to insufficient probably as a result of weight gain above 25 BMI. I would advise adequate zinc levels as well. I have no experience with Ivermectin or nattokinase.

4) The interesting study about IgG ratios was done on mRNA vaccines. I only took 2 J&Js, a flu vaccine, and shingles in the past 2 years. So my illness pattern did not appear to be mRNA caused. However, all 3 Covid vaccines used in US over 2 years targeted spike proteins, so with J&J also using spike protein, my illness could fit.

5) Much larger studies should be done on these changes in IgG ratios, and include J&J in addition to Pfizer and Moderna. The potentially useful anti Covid vaccine Novavax should also be studied since it uses neither mRNA or spike protein as its mode of action. So far as I know it has not been used publicly in the US but may have been used in several other large countries, so study subjects may be available.

6) Few recent articles on Novavax appeared at Google. This one from Jan. 2023 is behind a Barrons firewall, but I may get it from a friend: https://www.barrons.com/articles/novavax-covid-vaccine-pricing-51673558808
Another study from South Africa and printed Jan. 2023 on Covid variants showed good result. I was unclear from the highly technical language whether or not spike protein was used. https://www.nature.com/articles/s41598-023-27698-x

I will continue to seek more information on the common cause of various dangers from Covid vaccines, but meanwhile will continue to use supplemnts, sometimes in larger than “approved” doses on my 84 year old body. Fifty years of supplement use has kept me in better health than my ancestors including parents, and sharpened my body self-awareness for subtle changes in health and reactions. As my gynecologist 53 years ago said when I asked about supplements I was taking as a result of reading Adele Davis’s books: “I don’t know much about supplements, but you seem fine, and I see you regularly, so it is probably OK.” The only problem I have ever had was when I used too much Calcium and not enough Magnesium to help manstrual cramps. It threw me into a depression episode. In a few minutes of research in Adele Davis’s books I found “calcium/magnesium ratio”. I realized that I was magnesium deficient, and took a small amount of high magnesium epsom salts in water. Twenty minutes later the depression feeling was gone and I was cooking dinner.


27 posted on 05/31/2023 12:21:04 PM PDT by gleeaikin (Question authority!)
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To: Tunehead54; dennisw; Tilted Irish Kilt

If you have never considered using supplements, feeling you are dying suggests it is a good time to do so. You cand Google the name of your condition or symptoms and add “supplements and nutrition to help”. I wsa told cataracts were incurable and required surgery. I checked at Google and found several supplements to try. After 3 years my cataract vision problems are 70 to 80% improved and I feel no need for surgery. Also see my comment #27. God luck and hunting.


28 posted on 05/31/2023 12:38:26 PM PDT by gleeaikin (Question authority!)
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To: gleeaikin

zinc quercitin, vit d ester c a cntrum multi vitamin , baby aspirin

lisinopril

but thx

off everything for a week.

Just crawl across the floor
but really. Thx

When i can pick my head up ill look it all over. Thx.


29 posted on 05/31/2023 1:10:14 PM PDT by Tunehead54 (Nothing funny here ;-)
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To: gleeaikin

I hope you are using sodium ascorbate powder for your vitamin C. This is what Linus Pauling took. He took 6-10 grams daily.

When ill you want your blood to have high vitamin C all day long. You want vitamin C saturation of your blood. So 10 grams-— but in 5-6-7 divided doses.
_____________________

NOW Supplements, Sodium Ascorbate Powder, Buffered, Antioxidant Protection*, 8-Ounce
https://www.amazon.com/NOW-Sodium-Ascorbate-Powder-8-Ounce/dp/B000MGSHGQ


30 posted on 05/31/2023 1:23:09 PM PDT by dennisw (Never attribute to stupidity, that which is adequately explained by malice)
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To: dennisw

PING


31 posted on 06/01/2023 2:52:00 AM PDT by dennisw (Never attribute to stupidity, that which is adequately explained by malice)
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To: gleeaikin; All

If you haven’t seen this already [Jessica Rose
May 30, 2023]:

“IgG4 Antibodies Induced by Repeated Vaccination May Generate Immune Tolerance to the SARS-CoV-2 Spike Protein”
https://jessicar.substack.com/p/igg4-antibodies-induced-by-repeated

From Link:

Please refer to the newly published paper entitled: “IgG4 Antibodies Induced by Repeated Vaccination May Generate Immune Tolerance to the SARS-CoV-2 Spike Protein”1
published in Vaccines on May 17, 2023. The paper has remarkable findings and concludes that:

“Increased IgG4 synthesis due to repeated mRNA vaccination with high antigen concentrations may also cause autoimmune diseases, and promote cancer growth and autoimmune myocarditis in susceptible individuals.”


32 posted on 06/01/2023 8:10:47 AM PDT by Qiviut (I'm not out of control, I'm just not in their control. $hot $hills: Sod Off)
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To: dennisw; Tilted Irish Kilt; Qiviut

I have been taking around 6 grams of Vitamin C in 1 gram tablets for over 50 years. They keep my allergies to house dust, cigarette smoke, ragweed, and cool weather mold under control. Usually I take 2 grams in the morning and at night, and 1 gram tablets during the day as nasal congestion occurs. If I am doing heavy house cleaning I might take 2 grams before I start. I presume what I have been taking is ascorbic acid. A few times when sick I have mixed magnesium ascorbate powder into water and drunk that, and used anywhere from 12 to 24 grams over 24 hours.

On a wilderness campout 40 years ago I was volunteering at the camp’s MASH tent. A woman had been stung by 3 yellow jackets in her neck, and forgot to pack her bee allergy kit. Her eyes were swollen shut, she was choking and there was swelling all over her body. Something called “rescue remedy” had been given her but was not working. Fortunately they had a big bottle of 1 gram Vitamin C tablets. I crushed 10 and mixed with a glass of water and had her drink it. In 20 minutes her eyes were open, she was no longer choking, and the swelling on her body was much less. I spent the next 8 hours with her giving her 5 grams each hour. Finally, she said she felt better and she knew what she was feeling, so I left a handful of C tablets with her and hiked back to my tent at 4 am. So she had taken a total of 50 grams of C while I was with her. The next afternoon I went to see her and was told she and her friends had hiked the 3 miles to parking and she was much better.

I had read about the work of a southern Dr. Klener (sp?) who had used very high dose for poison snake bites and black widow spider bites. I figured if it worked for those poisons, it would probably work for wasp family poisons, and it did. More recently I have found the works of Dr. Robert Cathcart on the many uses of high dose Vitamin C for serious illness to be of great interest. His method of raising the dose to bowel tolerance is useful information. Using his name and those words at Google should probably find his writings. Of course the Fauci crowd just ignores his 10,000 successfully treated cases as merely “anecdotal” information. He recommends that a normally healthy person should take 4 grams of C a day at roughly 6 hour intervals.

I never have had stomach issues using Vitamin C in this way. I had ear infections when I was a child, so when my sons had colds and fever, after age 1, I would crush a 500 mg. C tablet, mix it with water, a tablespoon of honey, and 1/4 to 1/2 tsp. of garlic powder, put that in a baby bottle and shake well. THey would take it to bed and if they woke at night they would suck it and go back to sleep. They never had ear infections. I also found that for both them and myself it would drop a fever about 2 degrees. Like from 103 to 101 degrees. Some fever is healing, but not too high.
Babies under 1 should never have raw honey.


33 posted on 06/20/2023 7:24:15 PM PDT by gleeaikin (Question authority!.)
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To: gleeaikin

My love........ Sodium ascorbate is what these old line Docs were infusing into patients. I take Sodium ascorbate powder every day with Jarrow enhanced MSM

https://www.amazon.com/sodium-ascorbate-powder/s?k=sodium+ascorbate+powder

https://www.amazon.com/Jarrow-Formulas-Strengthens-Joints-1000/dp/B0013OSJ7S


34 posted on 06/21/2023 2:06:48 AM PDT by dennisw (Kust)
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