Posted on 04/18/2023 9:57:56 PM PDT by ConservativeMind
Preeclampsia is a dangerous complication during pregnancy that endangers both the mother and fetus. New research has uncovered a possible mechanism for how this potentially life-threatening condition occurs and the potential of hydroxychloroquine to treat it.
Researchers knew that in pregnancies complicated by preeclampsia, the development of the placenta is impaired. Furthermore, they knew levels of placental DNA in the mother's blood, known as cell-free fetal DNA (cffDNA), are significantly higher in women who experience preeclampsia.
So, a team led by Vikki Abrahams, Ph.D. studied the interactions of cultured placental cells called trophoblasts with levels of cffDNA observed in preeclampsia, and they found this significantly inhibited the movement of the trophoblasts. The team also found that treatment with hydroxychloroquine reversed the effects of cffDNA on the trophoblasts.
Preeclampsia, in which women experience highly elevated blood pressure, is a condition that normally manifests in the late second, or third, trimester of pregnancy.
Scientists have made an intriguing observation that if a clinician delivers the baby but not the placenta, women will continue to experience symptoms of preeclampsia until the placenta is also delivered.
This finding uncovered clues about preeclampsia's mechanism. cffDNA, says Abrahams, is different from adult DNA. The differences in structure of cffDNA have similarities to bacterial DNA, and consequentially, it gets recognized as such by an innate immune receptor called Toll-like receptor 9 (TLR9).
The team then turned their attention to hydroxychloroquine, a drug that is often given to patients with autoimmune diseases such as lupus and is safe to use during pregnancy. It also is a TLR9 inhibitor. They found that this medication did indeed restore the trophoblasts' ability to migrate. "This not only underscores the role of TLR9 as the mechanism by which cffDNA is inhibiting trophoblast migration, but also gives us a potential therapeutic," says Abrahams.
(Excerpt) Read more at medicalxpress.com ...
Strangely, the placenta is where the problem manifests itself.
G
A new study in March indicates Plaquenil uses multiple p450 enzymes. So if you plan on taking it full time you should be aware if you have the genetic p450 problem.
Also the popular quercetin can cause drug issues
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468908/
Most of the problems come from too much HCQ.
I took 1 20mg tab once a week (and zinc every day) to avoid the Chinavirus.
HCQ 'stays' and its main job is to help zinc absorb & do its work of preventing virus replication.
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