A new study in March indicates Plaquenil uses multiple p450 enzymes. So if you plan on taking it full time you should be aware if you have the genetic p450 problem.
Also the popular quercetin can cause drug issues
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468908/
Most of the problems come from too much HCQ.
I took 1 20mg tab once a week (and zinc every day) to avoid the Chinavirus.
HCQ 'stays' and its main job is to help zinc absorb & do its work of preventing virus replication.