People with NAFLD may have decreased expression of a liver enzyme needed for medication processing (Fatty liver prevents drug breakdown)

Medical Xpress / Indiana University School of Medicine / Nature Communications ^ | April 6, 2023 | Nicholas R. Powell et al

[ConservativeMind]

People with non-alcoholic fatty liver disease (NAFLD) may process certain medications less effectively due to significantly decreased levels of an important enzyme, according to a new study. A team of researchers led by Nick Powell, PharmD, and Naga Chalasani, MD, published their findings.

Powell said he and his team were building on existing evidence that people with NAFLD may be at risk for altered response to some commonly used medications.

"We wanted to see if this could be due to changes in how the liver expresses genes important to handling the metabolism and transport of these medicines in the body," he said.

Subsequently, the team found that the gene responsible for making an enzyme called CYP2C19 was significantly decreased in liver biopsies of people with worsening NAFLD.

"Further studies will be needed, but our results suggest that people with NAFLD will have slower clearance of certain medications from their body–like some antidepressants–and that medicines which use CYP2C19 to become activated may not work as well, such as the antiplatelet medicine clopidogrel," he said.

Naga Chalasani, MD said these findings could have a global impact.

"Our findings have immediate potential implications for patients with NAFLD and nonalcoholic steatohepatitis (NASH), which are both highly prevalent here in the United States and around the world," he said.

That impact is largely due to the potential for new approaches to development and prescribing of medications that are sensitive to metabolism by the CYP2C19 enzyme, according to the paper.

"Our findings are exciting from a precision medicine standpoint because we can now work on making medicines safer and more effective for people with NAFLD," said Powell.

[ConservativeMind]

There are a few ways to look at this.

1. Drugs stay in your body rather longer than they should. 2. Your doctor might be able to prescribe less. 3. You could lose some weight and get a normal response from the drugs.

[ConservativeMind]

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[Mark]

A message from the boss:

04/07/23 | Jim Robinson

Wouldn’t it be great if we could complete this FReepathon in under 60 days? Please get your donations in early and let’s get ‘er done! Thank you very much! Your support is greatly appreciated! God bless you.

[momincombatboots]

It appears the anti platelet med will not work as well…. That is extremely worrisome, as do has had multiple cardiac events.
The anti depressants will not clear, so that may explain some problems we are seeing with those.
Great article which impacts many.

[RummyChick]

you can upload your genetic material to genetic genie and it will pop up the drugs you have a problem with

you can purchase various dna tests with a false name if that is a concern.

however, it is a constantly evolving issue. For example, Plaquenil just had a study in march showing issues for p450