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New form of omega-3 could prevent visual decline with Alzheimer's disease (96% eye DHA content improvement)
Medical Xpress / Discover BMB, Annual Meeting of the Am Soc for Biochemistry and Molecular Biology ^ | March 27, 2023 | Sugasini Dhavamani et al

Posted on 03/28/2023 1:33:21 PM PDT by ConservativeMind

For the first time, researchers have developed a form of the omega-3 fatty acid docosahexaenoic acid (DHA) that is capable of crossing into the eye's retina to ward off visual declines related to Alzheimer's disease, diabetes and other disorders.

The DHA found in fish oil capsules is called triacylglycerol (TAG) DHA. Although TAG-DHA has benefits in other parts of the body, it does not reach the eyes. For the study, researchers created a new lysophospholipid form of DHA, or LPC-DHA. In studies using mice, LPC-DHA successfully increased DHA in the retina and reduced eye problems associated with Alzheimer's-like processes.

In healthy eyes, DHA is concentrated in the retina, where it helps maintain photoreceptors, the cells that convert light into signals that are sent to the brain. DHA deficiency in the retina is associated with vision loss. People with Alzheimer's disease, as well as those with diabetes, retinitis pigmentosa, age-related macular degeneration and peroxisomal disorders, frequently have abnormally low levels of retinal DHA, and visual impairments are common as a result.

"Increasing the retinal DHA at clinically feasible doses has not been possible until now because of the specificity of the blood-retinal barrier that is incompatible with the specificity of the intestinal barrier," said Dhavamani.

The researchers tested their LPC-DHA supplement in mice bred to exhibit early-onset Alzheimer's disease. After six months, mice that were fed LPC-DHA daily showed a 96% improvement in retinal DHA content as well as preserved retinal structure and function. In contrast, TAG-DHA supplements had no effect on retinal DHA levels or function.

The dosage of LPC-DHA used in the study is equivalent to about 250 to 500 milligrams of omega-3 fatty acids per day in humans.

(Excerpt) Read more at medicalxpress.com ...


TOPICS: Health/Medicine
KEYWORDS: alzheimers; dha; diabetes; eyedisease; lpcdha; omega3; vitamins
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I am sending this out because of the large improvement a form of liposomal Omega-3 can have on the eyes.

There appear to be at least four different companies making liposomal Omega-3 oil, which could be a similar process to this “lysophospholipid” form.

According to Wikipedia:

“The term lysophospholipid (LPL) refers to any phospholipid that is missing one of its two O-acyl chains. Thus, LPLs have a free alcohol in either the sn-1 or the sn-2 position. The prefix 'lyso-' comes from the fact that lysophospholipids were originally found to be hemolytic, however it is now used to refer generally to phospholipids missing an acyl chain. LPLs are usually the result of phospholipase A-type enzymatic activity on regular phospholipids such as phosphatidylcholine or phosphatidic acid.”

Some liposomal formulations do use these phospholipids to create their liposomal supplements.

1 posted on 03/28/2023 1:33:21 PM PDT by ConservativeMind
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To: Mazey; ckilmer; goodnesswins; Jane Long; BusterDog; jy8z; ProtectOurFreedom; matthew fuller; ...

The “Take Charge Of Your Health” Ping List

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2 posted on 03/28/2023 1:34:01 PM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind
Very interesting, and thanks for posting.

One wonders if the LPC-DHA might be able to better penetrate into other tissues and reduce inflammation thereabouts.

Thinking brain, prostate, injuries to ligaments, and etc.

3 posted on 03/28/2023 1:48:58 PM PDT by Seaplaner (Never give in. Never give in. Never, never, never...in nothing, great or small...Winston Churchill)
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To: ConservativeMind

Do we have any way to tell which supplements use these phospholipids to create their Omega-3? Have you been able to research and identify those?


4 posted on 03/28/2023 1:49:03 PM PDT by Herosmith ("Hindsight alone is not wisdom, And second-guessing is not a strategy." - GWB)
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To: ConservativeMind

Interesting!


5 posted on 03/28/2023 1:53:07 PM PDT by COUNTrecount ("I've always won, and I'm going to continue to win. And that's the way it is." -- Donald Trump)
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To: Herosmith

I have not.


6 posted on 03/28/2023 1:54:39 PM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind

Could you list the companies please? Thanks.


7 posted on 03/28/2023 1:56:34 PM PDT by CaptainK ("If life's really hard, at least its short")
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To: Seaplaner

Good question! If this helps certain conditions it would make a difference. It seems like if it can get to the retina it could also get to the brain.


8 posted on 03/28/2023 1:59:36 PM PDT by Wilhelm Tell (True or False? This is not a tag line.)
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To: ConservativeMind

Love all of these posts, thank you!


9 posted on 03/28/2023 2:06:13 PM PDT by 4Liberty (Dems loot & riot -called "protesting" by media. Repub's protest -called "looting & rioting" by media)
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To: ConservativeMind

4L8tr


10 posted on 03/28/2023 2:15:12 PM PDT by AFreeBird
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To: AFreeBird

More from the document:

Ophthalmology
MARCH 27, 2023

“Dietary LPC-DHA is enormously superior to TAG-DHA in enriching retinal DHA and could be potentially beneficial for various retinopathies in patients,” said Sugasini Dhavamani, a research assistant professor in the Department of Medicine at the University of Illinois at Chicago. “This approach provides a novel therapeutic approach for the prevention or mitigation of retinal dysfunction associated with Alzheimer’s disease and diabetes.”

Dhavamani will present the research at Discover BMB, the annual meeting of the American Society for Biochemistry and Molecular Biology, March 25–28 in Seattle.

While boosting DHA can help to prevent such declines, increasing retinal DHA content has been challenging with currently available supplements. For a dietary supplement to deliver DHA to the retina, the DHA must be able to first be absorbed from the intestine into the bloodstream and then cross from the bloodstream into the retina.

“Increasing the retinal DHA at clinically feasible doses has not been possible until now because of the specificity of the blood-retinal barrier that is incompatible with the specificity of the intestinal barrier,” said Dhavamani. “This study uses the novel approach of dietary LPC-DHA that overcomes both intestinal and blood-retinal barriers and improves retinal function.”

The researchers tested their LPC-DHA supplement in mice bred to exhibit processes similar to those found in early-onset Alzheimer’s disease. After six months, mice that were fed LPC-DHA daily showed a 96% improvement in retinal DHA content as well as preserved retinal structure and function. In contrast, TAG-DHA supplements had no effect on retinal DHA levels or function.

The results suggest that LPC-DHA supplements could help to prevent Alzheimer’s-related declines in visual function. Researchers say the approach should also be helpful for other disorders in which DHA deficiency and vision impairment are common.

The dosage of LPC-DHA used in the study is equivalent to about 250 to 500 milligrams of omega-3 fatty acids per day in humans. Since these studies were conducted in mice, further studies would be needed to confirm that LPC-DHA is safe and effective for use in humans.


11 posted on 03/28/2023 2:26:10 PM PDT by SgtHooper (If you remember the 60's, YOU WEREN'T THERE!)
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To: ConservativeMind

I have age-related macular degeneration, the wet kind. Any additional information on how to ge this product would be appreciated.


12 posted on 03/28/2023 2:28:19 PM PDT by DugwayDuke (Most pick the expert who says the things they agree with.)
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To: ConservativeMind

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8282213/


13 posted on 03/28/2023 2:40:11 PM PDT by Mount Athos
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To: ConservativeMind
For anyone interested...

Health benefits of docosahexaenoic acid and its bioavailability: A review

14 posted on 03/28/2023 2:43:50 PM PDT by mewzilla (We will never restore the republic if we don't first secure the ballot box.)
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To: Mount Athos

There is one good dietary source of LPC-DHA.

Fish roe (caviar).

It isn’t found in significant levels in other parts of fish.


15 posted on 03/28/2023 2:49:29 PM PDT by Mount Athos
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To: ConservativeMind

bkmk


16 posted on 03/28/2023 2:51:49 PM PDT by HartleyMBaldwin
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To: CaptainK; Herosmith
I can't vouch for any of these:

Nutra-supp
https://www.nutra-supp.com/product/liposomal-omega-3-250ml/

Empirical Labs
https://www.empirical-labs.com/vitamins-supplements/liposomal-dha/

Liposoma Nutraceuticals
https://liposomanutraceuticals.com/white-label-supplements-request/

Spec Nova
https://specnova.com/lipovantage/ingredients/

There may be others.

Someone would have to research if any of these approach the process in the way that it both crosses the intestinal wall and the blood brain barrier, but DHA does exist in eyes, normally, so it's got to get there, somehow.

17 posted on 03/28/2023 3:16:45 PM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: Herosmith

Aker BioMarine has developed a pilot product and production method for lysophosphatidylcholine (LPC)- bound EPA and DHA from krill.

Lysoveta is not on the market yet.


18 posted on 03/28/2023 3:28:11 PM PDT by Valpal1 (Not even the police are safe from the police!!!)
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To: Valpal1

https://www.thepharmaletter.com/article/aker-biomarine-in-deal-for-development-of-lysoveta

I think they are still jumping through FDA approval hoops.


19 posted on 03/28/2023 3:36:12 PM PDT by Valpal1 (Not even the police are safe from the police!!!)
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To: mewzilla
Interesting review article!

Thanks for linking.

20 posted on 03/28/2023 3:56:34 PM PDT by Seaplaner (Never give in. Never give in. Never, never, never...in nothing, great or small...Winston Churchill)
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