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HEALTH AND SCIENCE If you had Covid before you were vaccinated, you might have less immunity than you think, study says
CNBC ^ | TUE, MAR 21

Posted on 03/24/2023 7:52:16 PM PDT by nickcarraway

People who caught Covid-19 before they were vaccinated had a weaker immune response to the shots than those who never had the virus, potentially leaving them less protected against reinfection, new research shows.

Co-funded by the National Institutes of Health, the study released Monday challenges older research that suggested a prior Covid infection enhanced a vaccinated individual’s immune response — a phenomenon known as hybrid immunity, which some scientists believe provides the best protection against reinfection.

In the study, researchers from Stanford University analyzed how immune cells found in the blood called CD4+ T cells and CD8+ T cells respond to Covid infection and vaccination. Those cells work together to produce an immune response that can help fend off the virus, killing other cells that have been infected.

The study found that vaccinating people who had never been infected with Covid before produced “robust” CD4+ and CD8+ T cell responses to the virus. Vaccination in those people also generated cell-signaling molecules that recruit other immune cells to help fight Covid, they said. In contrast, researchers said vaccinating people with prior Covid infections produced “considerably lower” cell responses “with less functionality.”

Unvaccinated people who caught Covid had even lower levels of CD8+ T cells, they added.

The researchers said the findings suggest a Covid infection damages an important immune cell response that is crucial to fighting the virus, which might leave vaccinated individuals with a prior infection less protected.

“The apparent damage of the CD8+ T cell response by viral infection is cause for concern, and may leave even vaccinated individuals with a prior infection at risk for subsequent infections or other health issues,” study authors wrote. They also said the findings highlight the need to develop new vaccine strategies that will specifically boost CD8+ T cell responses in people previously infected with Covid.

Dr. Stuart Ray, a professor of medicine at Johns Hopkins University, said the study is surprising since it challenges what is known about hybrid immunity. But he added that “we have to be cautious anytime we’re surprised by something.”

Ray said the findings may stem from the way the study was designed, specifically pointing to how researchers examined immune cells in the blood, not the tissue.

“The cells in the blood are not an absolute measure of everything in the body. The cells we know protect us are also in our tissues fighting infections,” he told CNBC. “It’s like when you’re looking for something under the lamppost when it’s over the field nearby. You might not be looking at all the cells we care about.”

Ray said the study, while interesting, needs to factor in long-term knowledge about how Covid immunity works: “It’s probably not the last chapter in this story.”

The study comes as researchers continue to investigate Covid’s impact on individuals even after they recover from the virus, which has infected more than 100 million people in the U.S. alone since the outset of the pandemic. The nation continues to see nearly 150,000 new cases each week, according to the Centers for Disease Control and Prevention.

The new research also comes as public health officials consider new approaches to Covid vaccination that could decrease the number of doses people need per year or require drugmakers to periodically update their shots to target emerging variants of the virus.

Roughly 81% of the U.S. population is vaccinated with at least one Covid shot, while nearly 70% have completed their primary series doses, according to the Centers for Disease Control and Prevention.


TOPICS: Business/Economy; Health/Medicine; Science
KEYWORDS: annikakimconstantino
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1 posted on 03/24/2023 7:52:16 PM PDT by nickcarraway
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To: nickcarraway

Hmm. Is this saying I should run out and get the vax?


2 posted on 03/24/2023 7:56:26 PM PDT by Sarcazmo ("Sarcasm is the highest form of wit" ~ O. Wilde)
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To: nickcarraway
Too late, I lost confidence in the Covid "experts" three years ago.

3 posted on 03/24/2023 7:57:37 PM PDT by BitWielder1 (I'd rather have Unequal Wealth than Equal Poverty.)
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To: nickcarraway

The CDC is still beating the dead horse apparently.


4 posted on 03/24/2023 7:58:04 PM PDT by so_real ( "The Congress of the United States recommends and approves the Holy Bible for use in all schools.")
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To: nickcarraway

Really. Shut up. These bastards have zero credibility


5 posted on 03/24/2023 7:58:26 PM PDT by j.havenfarm (22 years on Free Republic, 12/10/22! more then 6500 replies and still not shutting up!)
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To: nickcarraway
People who caught Covid-19 before they were vaccinated had a weaker immune response to the shots than those who never had the virus, potentially leaving them less protected against reinfection, new research shows.

So, I guess that means that they will need more boosters.

Will they give extra Krispy Kremes?


6 posted on 03/24/2023 8:00:27 PM PDT by SIDENET (Whatever they're threatening, the vaxx is worse. Don't give in to coercion. )
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To: nickcarraway

So the CDC was wrong... AGAIN.

ThE sCiEnCe ChAnGeS.

How about this for a theory you brain dead morons - the body gives less of an antibody response because the body has seen the real thing and knows the poorly constructed vaccine is a FAKE not worth its time to generate a response for?


7 posted on 03/24/2023 8:03:45 PM PDT by Skywise
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To: nickcarraway

So only 19% of Americans are smart


8 posted on 03/24/2023 8:05:54 PM PDT by cyclotic
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To: Sarcazmo

And the lies continue....


9 posted on 03/24/2023 8:13:01 PM PDT by joma89 (Buy weapons and ammo, folks, and have the will to use them.)
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To: Sarcazmo

I will guess you could get more than one in a day if you shop around.


10 posted on 03/24/2023 8:26:35 PM PDT by Cold Heart
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To: nickcarraway

What the title should have been is.... “If you’ve been vaccinated you have a compromised immune system”....


11 posted on 03/24/2023 8:42:14 PM PDT by WinstonSmith1984
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To: Sarcazmo

Would it work?


12 posted on 03/24/2023 8:59:53 PM PDT by nickcarraway
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To: Cold Heart

I read stories about people getting 20 or more vaccines.


13 posted on 03/24/2023 9:01:02 PM PDT by nickcarraway
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To: cyclotic

I was coerced into taken the jab. Threatened with loss of income.


14 posted on 03/24/2023 9:02:38 PM PDT by central_va (I won't be reconstructed and I do not give a damn...)
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To: nickcarraway
Dr. Stuart Ray, a professor of medicine at Johns Hopkins University, said the study is surprising since it challenges what is known about hybrid immunity. But he added that “we have to be cautious anytime we’re surprised by something.”
15 posted on 03/24/2023 9:02:45 PM PDT by nickcarraway
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To: nickcarraway

I got one shot 2 years ago and it is still trying to kill me.


16 posted on 03/24/2023 9:07:07 PM PDT by Cold Heart
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To: nickcarraway

I had covid but never got the “vaccine.” And I never will get it.


17 posted on 03/24/2023 9:07:48 PM PDT by rfreedom4u ("You may all go to hell and I will go to Texas")
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To: rfreedom4u

Ditto


18 posted on 03/24/2023 9:20:50 PM PDT by ChildOfThe60s ( If you can remember the 60s.....you weren't really there..)
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To: BitWielder1

Yuppers
Battles against the Hoax have been an Escape from ALCATRAZ and
Someone Owes me Three Years !


19 posted on 03/24/2023 9:25:40 PM PDT by Big Red Badger (The Truman Shown)
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To: nickcarraway

Why do they write such a long, convoluted article without the simple sentence that

vaccines reduce natural immunity to the wuhan coronavirus

The way they write is a parody of how Soviets or North Koreans would write due to the demands of the Ministry of Truth.


20 posted on 03/24/2023 9:31:12 PM PDT by TTFX
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