Scientists uncover protective role of NAD maintenance in kidney disease (Nicotinamide riboside or nicotinamide mononucleotide)

Medical Xpress / Perelman School of Medicine at the University of Penn / Nature Metabolism ^ | March 22, 2023 | Joseph Baur et al

[ConservativeMind]

Roughly one million people die of untreated kidney failure, worldwide, each year. Despite the major personal and economic burden, only a few new approaches have been deployed to treat or cure kidney disease over the last 40 years.

Metabolic changes related to an enzyme "helper molecule"—called nicotinamide adenine dinucleotide (NAD)—may serve as the basis for a future treatment or preventive measure for kidney disease, according to a discovery by a new study.

Metabolic changes related to NAD may offer a new therapeutic target to improve the course of kidney disease. By mapping metabolite changes in healthy and diseased mouse and human kidneys, the scientists consistently identified differences in levels between healthy and diseased kidneys, including a prominent decrease in NAD in those that were diseased.

But when mice in the study were provided with an over-the-counter supplement, it was shown to be effective in reversing NAD loss. This indicates that NAD could play an important role in protecting from kidney dysfunction.

Prior to this study, samples from human patients have not been used in metabolomic studies, meaning the studies of small molecules (like metabolites), in relation to kidney disease.

Using unbiased metabolomic studies, the team identified changes in NAD metabolism in both mouse and human kidneys. In the mouse studies, they showed that using a common supplement, nicotinamide riboside or nicotinamide mononucleotide, to boost NAD protected mice from kidney dysfunction by protecting the mitochondria—the powerhouses—of kidney tubule cells.

Kidney tubule cells are used to return critical filtered nutrients to the body's blood stream. And when the mitochondria in those cells are damaged, the researchers found, a pathway causing inflammation and kidney disease development is activated. By preventing the damage to mitochondria, NAD supplements suppressed this inflammation and protected mice from kidney injury.

[ConservativeMind]

Nicotinamide riboside or nicotinamide mononucleotide, both of which are available as supplements at this time, appear to at least help prevent some kidney damage, if taken prior to the injury.

Whether they help after injury, or not, was not addressed by this study.

[ConservativeMind]

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[dangus]

If you get hit in the NADs, even your kidneys will hurt.

[Pete from Shawnee Mission]

Thanks for this and for the Modified Citrus Pectin posts! Good information for older Freepers!

[Coleus]

I wonder if niacinamide can help.

[Bobalu]

Heh, heh... he said nad

[jimwatx]

Take that along with D-Ribose and it might.

[jimwatx]

A Combination of Nicotinamide and D-Ribose (RiaGev) Is Safe and Effective to Increase NAD+ Metabolome in Healthy Middle-Aged Adults: A Randomized, Triple-Blind, Placebo-Controlled, Cross-Over Pilot Clinical Trial

https://pubmed.ncbi.nlm.nih.gov/35684021/

[Pete from Shawnee Mission]

Thanks for this and for the Modified Citrus Pectin posts! Good information for older Freepers!