Posted on 03/09/2023 8:23:06 PM PST by ConservativeMind
A new study brings precision to the understanding of which antibiotics work best for acne treatment and why. This is important for two key reasons. Acne affects nearly everyone at some point in life—it is, in fact, the eighth most common disease for all humans, affecting more than 85% of adolescents and young adults. And second, because antibiotics have long been an important go-to treatment for acne, dermatologists write more antibiotic prescriptions than any other specialty in medicine.
Broad-spectrum antibiotics do not distinguish between good and bad bacteria, so they try to inhibit them all. In contrast, narrow-spectrum antibiotics target specific pathogens, giving beneficial bacteria a chance to survive.
About three quarters of prescriptions dermatologists write are for tetracycline-class antibiotics. A new Yale study examined sarecycline, a third-generation tetracycline derivative with a narrow-spectrum activity, which targets Cutibacterium acnes, the bacterium most doctors believe is behind acne and promotes skin inflammation.
…But in 2018, the FDA approved a new antibiotic called sarecycline for the treatment of moderate-to-severe acne vulgaris. Unlike its predecessors, this new drug has specificity for C. acnes and other clinically-relevant Gram-positive bacteria.
…Their model revealed a surprising finding. Unlike other antibiotics, sarecycline is bound to not one, but two active sites on the ribosome.
…Their discoveries are groundbreaking. This is the first group to visualize the structure of the C. acnes ribosome itself and make several intriguing observations. They learned that the ribosomes have proteins with zinc-free and zinc-bound isoforms. Some dermatology research suggests that zinc supplementation might help treat acne vulgaris and help antibiotic treatments work better. This work further supports that zinc supplementation may be helpful in treating acne.
(Excerpt) Read more at medicalxpress.com ...
I was given accutane when I was in high school.
I did not want it, but the the doctor told me it was totally safe and a vitamin A derivative so totally safe and effective.
It destroyed my night vision and even now I cannot see well except in bright sunlight. If it is cloudy and raining I will not even drive.
worse it made me want to kill people.
I realize this is not exactly addressing the article or the science. But, if my experience is helpful to someone or their child, I will share it. From age 17 to 21 I was strung along by dermatologists who gradually ratcheted me up from erythromycin, to tetracycline, to minocin. The only thing that got me off the conveyor belt was an intense allergic reaction after being on minocin for almost 2 years. Did my acne improve over that time? Well, sometimes it seemed to be getting better, and sometimes it didn’t. But, pimple after pimple, pock mark after pock mark I thought I just had to follow through with the advice of my doctors who insisted accutane was “too strong” and not right for me.
Well, after I recovered from my allergic reaction and a friend gave me the name of a doctor that prescribed accutane for her, I went to see this 80 year old blue haired physician who prescribed what I wanted on the first visit and I have been acne free since.
If only I had found him first. Antibiotics for acne might be okay if you don’t have much of a problem to begin with, but if you want a cure for a bad case, accutane it.
Very interesting. Smart mother!
My daughter took accutane. It cleared her skin beautifully, but she still has side effects 10 years later, but not bad.. mostly dry eyes and nose. She’s now 26. My sister , who is 62 did it about 3 times I think.
I think they now use Ivermectin cream for roscea.
I think accutane works by reducing the parathyroid hormone.
One can reduce the parathyroid hormone by
having a good level of vitamin d
sun exposure
consumption of potassium and calcium
if one has excess retinol, reducing it. drinking beer, yogurt, smoking cigarretes and sun exposure reduce it.
Thankfully my mom never gave us any medicine she had not checked out thoroughly.
Can I send you a list?
No, no, no, no, no.
This piece is a reckless contradiction in human health and anyone giving it any credence whatsoever is a fool.
It was a mistake to post this.
What is your alternative cure?
Accutane is poison. Between that assault as an early teen and Crestor as a young adult, I’m fortunate to have my health at all.
In the course of my health recovery, I not only accidentally cured a lifetime of seasonal allergies but was pleased to discover that I also cured myself of persistent adult cystic acne.
This posted piece is a dereliction to its stated purpose and represents the very worst on the topic.
It never occurred to me that my poor night vision was due to accutane. In hindsight, I did fare far better before that period when I was 13. I regret that they conned my parents to this day.
Thanks for posting.
Remember, having some pimples on your face as a teenager is not “acne”.
Vitamins like zinc and D3 will help. Exercise too. Just going out and about will sweat the pores clean.
Get rid of laundry detergent like original Tide and use their Free and Clear. Same for Arm & Hammer Free and Clear.
The laundry detergent was the worst cause. Get those that say Free and Clear and dermatologist approve.
Use witch hazel like THAYERS Alcohol-Free to clean face.
Guys get rid of shaving cream like Edge or similar and get something like Aveeno Therapeutic Shave Gel. It does not clog up the blades and leaves the face clean.
Also use soap like Dove or Ivory and Kirk’s 3 in 1 Castile Clean Mint Shampoo Body Wash Liquid Soap | Mint & Eucalyptus Scent
Other soaps like Dial Gold will leave soap residue on surfaces in the sink and shower and you.
Use Head and Shoulders which will clear up any acne and keep your scalp clean. No buildup. Kirks is another that is clean soap with no residue.
Stop drinking lots of soda. The sugar can be a cause too.
If it was easy to explain, the first draft of my book wouldn’t have been 300 pages.
But there IS linkage between gut health, skin health and unnatural fats. I would argue that all skin conditions have their roots in the gut; the 2nd volume of the book is literally all about the gut. Sadly, not one person during my 3 years of outreach was willing to undertake a regimen even as a test, so other than myself as a test subject, it is admittedly anecdotal.
That failure was a double-edged sword; I cannot elaborate, other than to say ‘major breakthrough’.
Insofar as acne alone, diet-wise, in my case for example, ingesting anything with palm oil as an adult is instant adolescent appearance.
I am debating a substack to both reengage on such matters and invigorate a needed return to the book rewrite; I have a major motivation inhibition due to the true pandemic.
So the guys at Harvard are wrong? Then there must exist a paper refuting them. The study seemed legit
I’ll put it in no uncertain terms:
Any ‘doctor’ who ties health to antibiotics should lose their license automatically and be barred from medicine due to abject stupidity. Likewise for so-called ‘researchers’ writing BS papers just to qualify their grants.
I don’t care from which pit of hell they hail.
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