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Life After Food? A Diabetes Drug Has Become an Off-Label Appetite Suppressant, Changing the Definition of Being Thin and What It Takes to Get There.
The Cut ^ | 2/28 | Matthew Schneier

Posted on 02/28/2023 3:32:48 PM PST by nickcarraway

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1 posted on 02/28/2023 3:32:48 PM PST by nickcarraway
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To: nickcarraway

This is not a bad drug. It should be used for diabetes. Considering the side effect profile it should not be used for weight loss. The manner in which she obtains the drug and little supervision by a doctor is dangerous. I have no problems with drugs being used for off patent purposes. I have a problem with the lack of medical supervision by doctors as is this case.

The stupid is strong in this girl.

cpdiii retired clinical pharmacist


2 posted on 02/28/2023 3:44:10 PM PST by cpdiii (cane cutter-deckhand-roughneck-oil field trash- drilling fluid tech-geologist-pilot- pharmacist)
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To: nickcarraway

Just sat next to a dude on a plane whose entire left side rubbed against me the entire flight. The armrest was down when he sat, but I told him we could put it up because half his rear end was hiked up on it.

If only these drugs could get into the hands of obese patients without diabetes. Hopefully, after clinical trials the prices of the drugs in this article will go down so that everyone who needs them can access them.


3 posted on 02/28/2023 3:49:40 PM PST by Reddy (BO stinks)
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To: cpdiii

Pretty sure this drug is only available with a prescription?

Most insurance companies will no longer pay for it (also no coupons can used for it) unless the patient has diabetes diagnosis.


4 posted on 02/28/2023 3:51:58 PM PST by Reddy (BO stinks)
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To: nickcarraway

Or these people could just not eat as much; walk a little; and understand what they are normally feeling is not “hunger” but rather a drop in blood glucose.

Proper eating and nutrition is easy to achieve. It just takes a little time and some education.

I loose weight without shitting my brains out.


5 posted on 02/28/2023 3:52:14 PM PST by Vermont Lt
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To: cpdiii
cpdiii retired clinical pharmacist

Okay, do you keep in touch with pharmacists? What is going on with pharmacists these days? They seem to have gone mad with power.

To give a few examples:

A patient with treatment-resistant depression was prescribed a spray ketamine that was approved specifically for such a case by an anesthesiologist who treats depression. When the pharmacists saw the prescription he freaked out at the patient and screamed at him that it was a horse tranquilizer and he would never fill the prescription. It's patently false, because almost every emergency room in the country has it in stock. And this specific form was approved in the last five years to treat depression. Now the patient is scared to try anything for their depression.

A Walgreen's pharmacist recently screamed at a doctor I know over a prescription. She said the doctor did not have a medical license. [Not true - I've seen her license and her degree from Tulane] and she told the doctor she would need to see lab work before she filled the prescription. And this was over something like a .25 mg difference in an existing prescription. Since when do pharmacists have the right to ask for lab work?

This is one of many examples I've heard of lately of pharmacists oyut of control.

6 posted on 02/28/2023 3:59:12 PM PST by nickcarraway
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To: Reddy

They have other medication, like Topomax, but I am not sure any of them are great.


7 posted on 02/28/2023 4:00:05 PM PST by nickcarraway
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To: Vermont Lt

Unfortunately, a lot of the charts and guidance from the medical community are part of the problem.


8 posted on 02/28/2023 4:00:57 PM PST by nickcarraway
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To: nickcarraway

Once upon a time, young women lost weight with a diet of Tab and Marlboro Lights.


9 posted on 02/28/2023 4:07:02 PM PST by irishjuggler
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To: irishjuggler

Marlboro Lights? Personally, I don’t like women who smoke it all. But ML are too masculine a cigarette to smoke.


10 posted on 02/28/2023 4:08:40 PM PST by nickcarraway
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To: nickcarraway
My wife is a T1 diabetic. Insulin dependent with a continuous glucose monitor (Dexcom G6) and insulin pump (Tandem TSlim2). It's a closed-loop glucose/insulin system. When she plans to eat, she enters the approximate amount of carbs to the pump (or iPhone app). A "bolus" i.e. extra insulin is added on top of the "basal" i.e. constant insulin requirement. Sometimes exercise or food estimates are off and her blood glucose drops too quickly. The pump will stop adding insulin, but the "damage" is done. Too much insulin needs to be countered. Typically a small amount of glucose gel or a cookie can add enough glucose to counter a dangerous glucose low. Usually the problem resolves in 10 minutes.

Enter Ozempic. My wife's doctor prescribed Ozempic to help control appetite and glucose levels. The effect on her is to delay the dump of carbs from her stomach. She has to delay entering the carb estimate into the insulin pump to prevent having the insulin taking effect while the carbs from the meal are delayed leaving the stomach by the Ozempic. Sometimes she misjudges and faces a glucose level dropping and consuming glucose doesn't help because of the Ozempic. It's a potentially harmful situation for a T1 dependent on doing the delicate balancing act between insulin and glucose intake.

In the event that the glucose low becomes dangerous, she has a special nasal inhaler that causes a glucose dump into her blood. It's intended as a rescue tool in case of a severe low.

11 posted on 02/28/2023 4:10:23 PM PST by Myrddin
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To: nickcarraway

I have type 2 diabetes, and last summer my doctor convinced me to try Trulicity, which is another manufacturers drug that works on the same principle as Ozempic.

Basically, they are antabuse for fat people. They make you sick to your stomach when you eat too much.

They do lower your average blood sugar a little, but at the price of being up at 3am with ‘nausea’ (and all the gross accompaniments of nausea).

After being up for five consecutive nights a few weeks ago, I decided that I would rather just try to eat a little more salad, a little fewer carbs, and get my 10,000 steps of walking in.

The fact that the FDA approved a drug that works by making you not want to eat because you’re sick all the time gives me even less confidence in them than I already have.


12 posted on 02/28/2023 4:15:19 PM PST by CaptainMorgantown
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To: Vermont Lt

If you have insulin resistant fat cells dieting and exercise basically do not work very well. You do not lose weight you just get lethargic.


13 posted on 02/28/2023 4:21:30 PM PST by Fai Mao (Starve the beast and steal its food!)
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To: CaptainMorgantown
Have you ever read anything by Jason Fung, especially The Diabetes Code?
14 posted on 02/28/2023 4:22:34 PM PST by nickcarraway
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To: nickcarraway

How can anyone possibly write this much drivel?


15 posted on 02/28/2023 4:31:08 PM PST by Sequoyah101 (Procrastination is just a form of defiance.)
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To: Fai Mao
I have found that not to be the case if you eliiminate all sugar and go very low carb and for good measure avoid seed oils, artificial sweeteners and low quality ingredients. Just FWIW. But yeah just eating less without changing what you eat is, IMO, doomed to failure.
16 posted on 02/28/2023 4:33:46 PM PST by Stingray51 ( )
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To: Fai Mao
I have found that not to be the case if you eliiminate all sugar and go very low carb and for good measure avoid seed oils, artificial sweeteners and low quality ingredients. Just FWIW. But yeah just eating less without changing what you eat is, IMO, doomed to failure.
17 posted on 02/28/2023 4:34:32 PM PST by Stingray51 ( )
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To: nickcarraway
This article is just click bait and sensationalizes the issue.

Ozempic is semaglutide and it IS approved for weight loss by the FDA. The manufacturer changed the name and called it Wegovy, predictably they increased the prices for the weight loss version also. It's the EXACT same medicine, just sold under a different name and stamped "weight loss" on the box.

It's a myth that most people can lose weight and keep it off with diet and exercise. By the time someone resorts to medicine that costs $1400 a month they've tried everything else and it doesn't work. Everyone's body works differently, if they were the same then we'd all be 6'4" and could throw a football like Tom Brady. If you're skinny then pat yourself on the back because you won the genetic lottery, it's not because you worked harder.

Fat people are the last remaining group that it's fashionable to hate. Some jackasses just aren't happy unless they have someone to look down upon. These drugs have the potential to help an incredible number of people live a decent life but the media loves to sensationalize by focusing on a few hollywood types that take it to lose 10 lbs. They won't write an article about the guy that lost 150 lbs and now will live to see his kids goe to college.

18 posted on 02/28/2023 4:35:06 PM PST by GaryCrow
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To: nickcarraway

Holy cow!!! A thousand bucks for that stuff.😱


19 posted on 02/28/2023 4:39:52 PM PST by BiteYourSelf ( Earth first, we'll strip mine the other planets later.)
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To: Fai Mao

I had 280 pounds of insulin resistant fat cells. I had to work my ass off (literally) every day for the past year. 4-5 miles most days. 6.5 on sunny days. Cut out the sweets. And measure everything I ate.

I’ve lost about 45 pounds and my A1c is “normal.”

It’s hard and it takes a while.


20 posted on 02/28/2023 4:42:33 PM PST by Vermont Lt
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