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Study of intravenous mistletoe extract to treat advanced cancer
Medical Xpress / Johns Hopkins University School of Medicine / Cancer Research Communications ^ | Feb. 22, 2023 | Channing J. Paller et al

Posted on 02/24/2023 3:04:01 PM PST by ConservativeMind

Mistletoe extract has been widely used to support cancer therapy and improve quality of life, but there has been a lack of clinical trials to support its use. Researchers completed what is believed to be the first phase I trial of intravenous Helixor M in the U.S. aimed at determining dosing for subsequent clinical trials and to evaluate safety.

Channing Paller, M.D. also documented improved quality of life and some disease control.

Mistletoe extract (ME), known as Helixor M, was studied in 21 patients with advanced and treatment-resistant cancers of various types. The phase I trial used dose escalation to determine the maximum dose that could be safely tolerated by patients. ME was delivered intravenously three times per week until disease progression or until toxicity. The study concluded that dose to be 600 milligrams of ME.

The median follow-up duration on mistletoe was 15.3 weeks. Stable disease was observed in five patients and lasted, on average, for 15 weeks. Tumors in three participants decreased in size, and remained stable for two to five months, however, this did not meet official criteria for partial response. Patients also reported overall improved quality of life via a questionnaire. The most common side effects reported were fatigue, nausea, and chills and they were noted as manageable.

Mistletoe extract is a plant with several active ingredients that, in preclinical studies, appear to directly cause the death of tumor cells and stimulate an immune response. It has been used in Europe for several decades as a complementary medicine approach to cancer treatment alone or in combination with chemotherapy and radiation therapy, but it has not been evaluated in clinical trials.

ME is not currently FDA approved for cancer treatment in the U.S. but is listed in the Homeopathic Pharmacopoeia and is offered in integrative care clinics.

(Excerpt) Read more at medicalxpress.com ...


TOPICS: Health/Medicine
KEYWORDS: cancer; cheapskate; donatetofreerepublic; mistletoe; treatment
An over the counter edible extract is available, but it may also be available from some naturopaths.
1 posted on 02/24/2023 3:04:01 PM PST by ConservativeMind
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To: Mazey; ckilmer; goodnesswins; Jane Long; BusterDog; jy8z; ProtectOurFreedom; matthew fuller; ...

The “Take Charge Of Your Health” Ping List

This high volume ping list is for health articles and studies which describe something you or your doctor, when informed, may be able to immediately implement for your benefit.

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2 posted on 02/24/2023 3:04:42 PM PST by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind

It’s not that the mistletoe has any direct effect.
It’s all the kissing that occurs when you become walking mistletoe, that raises the spirit and crushes the cancer.💋


3 posted on 02/24/2023 3:29:44 PM PST by DannyTN
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To: ConservativeMind
I have not taken mistletoe extract but do take boswellia (extract of Indian frankincense)

So far, test-tube studies suggest that frankincense may fight breast, prostate, pancreatic, skin, and colon cancer cells (25Trusted Source, 24Trusted Source, 26Trusted Source, 27, 28Trusted Source, 29Trusted Source). Test-tube studies suggest that the boswellic acids it contains might prevent cancer cells from spreading (24Trusted Source, 25Trusted Source). A research review notes that boswellic acids may also prevent the formation of DNA in cancerous cells, which could help limit cancer growth (1Trusted Source).

4 posted on 02/24/2023 3:50:57 PM PST by steve86 (Numquam accusatus, numquam ad curiam ibit, numquam ad carcerem™)
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To: ConservativeMind

would there be a benefit to taking this in low dose form?


5 posted on 02/24/2023 4:37:09 PM PST by ckilmer (q)
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To: ckilmer

Ping


6 posted on 02/24/2023 4:46:47 PM PST by Babsig
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To: ConservativeMind

Likely the reason it’s intravenous is to bypass the liver.


7 posted on 02/24/2023 5:57:16 PM PST by cicero2k
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To: cicero2k

Everything in our bloodstream goes through the liver.

I think it is in an IV to bypass gut absorption issues.


8 posted on 02/24/2023 8:47:42 PM PST by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ckilmer

I wouldn’t do so, off of this study.

I would only look at it if I had cancer. I really don’t know what else it might conflict with.


9 posted on 02/24/2023 8:50:18 PM PST by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind

Liver gets the first opportunity to filter oral drugs before the rest of body. Agents like vitamin C are given to cancer patients intravenously because the liver is so effective.


10 posted on 02/25/2023 6:58:37 AM PST by cicero2k
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To: cicero2k

Your understanding of the process of food getting into the body is a bit off.

Our intestines directly pass nutrients into our circulatory system (blood). There is nothing that routes to the liver over all the other organs, first.

https://www.niddk.nih.gov/health-information/digestive-diseases/digestive-system-how-it-works


11 posted on 02/25/2023 9:19:20 AM PST by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind
The ABCs of drug transport in intestine and liver: efflux proteins limiting drug absorption and bioavailability”

From Pub Med.

The article doesn’t specify the percentage of food/drugs grabbed by liver first but it’s substantial.

Mistletoe, vitamin C, quercetin are dripped intravenously over hours to bypass intestine and liver.

12 posted on 02/25/2023 10:23:49 AM PST by cicero2k
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To: cicero2k

All blood goes through the liver, if it goes through the heart.

Think it through.


13 posted on 02/25/2023 10:27:56 AM PST by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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