Posted on 02/19/2023 9:00:14 AM PST by ConservativeMind
Bone has the amazing capacity to regenerate. After a fracture, bone will heal without scarring in healthy people. In aging individuals, or for people with diseases like diabetes, approximately 10% of long bone fractures fail to heal well and require growth factors—or substances to help stimulate regeneration of specific tissues—to heal completely.
Two growth factors—bone morphogenetic protein 2 (BMP2) and platelet-derived growth factor (PDGF)—are currently approved by the Food and Drug Administration (FDA) to assist with bone healing. But combining them may make them less effective, Ivo Kalajzic, professor and Sanja Novak, instructor. Their study evaluated the osteoanabolic—or bone forming—effects of PDGF BB and BMP2 when used together.
Bone morphogenic proteins are important regulators of bone regeneration, while platelet-derived growth factors help regulate cell growth and division. Alone, BMP2 helps increase bone mass and healing. But after evaluating mice treated with both PDGF and BMP2, the researchers found PDGF inhibits BMP2-induced bone growth.
To test the impact of both growth factors when combined, the researchers used multiple genetically modified mice and used microsurgical approaches to create bone fractures and "critical size" bone defects—or defects 20% of bone length.
The researchers discovered the negative role of PDGF signaling in regulating BMP2-induced bone formation when placed within the bone defect. The combined treatment of critical sized defects early in the healing process decreased osteoprogenitor—or bone forming—cell numbers and limited the expansion of stem/progenitor cells, resulting in less bone formation nine weeks after the defect. However, inhibition of PDGF signaling early in the healing process did not lead to improved BMP2-induced osteogenesis, indicating PDGF is required for the healing process.
The study shows that two individual bone building agents, when combined, can actually decrease bone growth. The data shows how important timing and location are to bone growth factor effectiveness and proper healing.
(Excerpt) Read more at medicalxpress.com ...
Sometimes less is more.
Had a cat with a bone break. The vet said don’t worry,
if all the pieces are in the same room, it’ll mend.
.
I wonder if BMP2 & PDGF have names that we’re familiar with. I checked the article, but didn’t see it.
“Two growth factors—bone morphogenetic protein 2 (BMP2) and platelet-derived growth factor (PDGF)—are currently approved by the Food and Drug Administration (FDA) to assist with bone healing.”
BMP2 has problems, but is used (injected, it seems) for spinal fusions and other bone work.
A Review of the Clinical Side Effects of Bone Morphogenetic Protein-2
https://pubmed.ncbi.nlm.nih.gov/26857241/
Bone Morphogenetic Protein-2 in Development and Bone Homeostasis
https://pubmed.ncbi.nlm.nih.gov/32933207/
Platelet-derived growth factor seems to be used for a variety of occasions, also injected:
https://en.m.wikipedia.org/wiki/Platelet-derived_growth_factor
I think I’d prefer the PDGF.
For osteoporosis they want me to give myself daily shots of Forteo, which is supposed to regenerate bone. I read tons of reviews and the majority of side effects are atrocious. Decided against it. Will take my chances with calcium.
I thought one of these treatments in the article might address that, but probably not.
Thank you for replying with the info!
D3 is best to distribute your calcium intake. To where it is needed. 100000 D3 daily with some K2.
“D3 is best to distribute your calcium intake”
Thanks for that. I do take about 8,000 IU of D3 daily. (The 100,000 you mention — is that IUs? Isn’t that a lot?) Will have to add the K2 ‘cause I don’t do that now.
The instructions on the d3 (the ‘Hammer’) 50,000 IU tablets say one per WEEK. You should take the K2 MK-7 with your d3, though.
My lovely..... You are right on the level for your daily D3 intake. That your doc can always do a free blood analysis on this. When the (woke) world is running down. You gotta do the best with what’s still around
(Sting 1983 or so)
But K2 helps balance the D3. https://www.amazon.com/Vitamin-Formula-Soft-gels-Absorption-Support/dp/B07RX4P4RL
“You are right on the level for your daily D3 intake. That your doc can always do a free blood analysis on this.”
I have two regular blood tests each year, and I make sure D3 is tested. My results in December were “perfect” for D3. Yay! (Your 100,000 threw me off - LOL!)
Yeah, it is 10000 iu D3 daily. My older sisters are mesmerized by osteoporosis. So a great idea (you) to take counter measures.
You may want to consider these supplements:
https://www.healthline.com/nutrition/osteoporosis-supplements#boron
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