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New way to reduce progression of diabetic kidney disease discovered (Spironolactone)
Medical Xpress / University of Bristol / JCI Insight ^ | Feb. 7, 2023 | Dr. Matthew Butler et al

Posted on 02/08/2023 3:10:01 PM PST by ConservativeMind

A new method to reduce the progression of diabetic kidney disease, affecting 40% of people with diabetes, has been discovered by scientists. The study could help people with diabetes who are four times more likely to need either dialysis or a kidney transplant.

Recent clinical trials show a commonly used blood pressure medicine, known as spironolactone, is an effective treatment by reducing protein leak into the urine. However, despite its positive effect, the drug can have adverse side effects, causing problems including high blood potassium levels (hyperkalaemia) in patients, making clinicians reluctant to use it.

Researchers aimed to understand how spironolactone prevents damage to the kidneys.

They found that the drug has a protective effect by helping preserve the gel-like glycocalyx layer on the surface of blood vessels within the kidney. Using novel alternative therapeutics to slow down glycocalyx layer degradation in diabetes directly could now help them recreate the same effect but without adverse side effects.

To conduct this study, the team used patient kidney biopsy specimens to develop a novel method to measure glycocalyx depth changes to confirm that diabetes damages the endothelial glycocalyx layer, and spironolactone prevents this damage.

Their results showed spironolactone reduces the activity of a group of enzymes, called matrix metalloproteases, helping to preserve the gel-like glycocalyx layer on the surface of the blood vessels in the kidney, preventing disease progression.

Dr. Matthew Butler said, "This study is really exciting for us because it confirms that blocking mineralocorticoid receptors using spironolactone preserves kidney function by acting on the glycocalyx.

(Excerpt) Read more at medicalxpress.com ...


TOPICS: Health/Medicine
KEYWORDS: diabetes; donate; kidneydisease; spironolactone
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Spironolactone is commonly available. It may be possible to switch blood pressure drugs to this one, and get double the benefit. Talk with your doctor.

If the glycocalyx in the kidney is effectively similar to that elsewhere in the body, rhamnan sulfate has been found to restore it. It is available in a supplement called “Arterosil.” It appears to help reverse plaques in our arteries.

1 posted on 02/08/2023 3:10:01 PM PST by ConservativeMind
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To: Mazey; ckilmer; goodnesswins; Jane Long; BusterDog; jy8z; ProtectOurFreedom; matthew fuller; ...

The “Take Charge Of Your Health” Ping List

This high volume ping list is for health articles and studies which describe something you or your doctor, when informed, may be able to immediately implement for your benefit.

Email me to get on either the “Common/Top Issues” (20 - 25% fewer pings) or “Everything” list.

2 posted on 02/08/2023 3:10:38 PM PST by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind
Another side effect of Spironolactone, is that men grow boobies.
3 posted on 02/08/2023 3:17:56 PM PST by Carriage Hill (A society grows great when old men plant trees, in whose shade they know they will never sit.)
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To: Carriage Hill

This is the stuff male trannies use to act like women


4 posted on 02/08/2023 3:21:34 PM PST by struggle
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To: ConservativeMind

Ping


5 posted on 02/08/2023 3:23:11 PM PST by Java4Jay (The evils of government are directly proportional to the tolerance of the people. )
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To: ConservativeMind

I have been taking it for years, good to know this may have a positive effect on kidney disease..


6 posted on 02/08/2023 3:32:18 PM PST by Shady (The #JihadJunta: "We are now a nationThat of Men, Not of Laws. You are not as equal as we are...")
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To: Carriage Hill

That’s true.


7 posted on 02/08/2023 3:35:49 PM PST by Shady (The #JihadJunta: "We are now a nationThat of Men, Not of Laws. You are not as equal as we are...")
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To: ConservativeMind

bkmk


8 posted on 02/08/2023 3:35:56 PM PST by sauropod (“If they don’t believe our lies, well, that’s just conspiracy theorist stuff, there.”)
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To: ConservativeMind
I'm on the stuff. Victoria's Secret still doesn't have anything in my size.

Or so a friend told me...

9 posted on 02/08/2023 3:38:35 PM PST by Billthedrill
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To: ConservativeMind

Taking that stuff is like taking your kidneys to the kidney gym all day.


10 posted on 02/08/2023 3:38:42 PM PST by Paladin2
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To: struggle; Shady

It’s used, in conjunction with other drugs and hormones, to help men ‘transition’ to women.


11 posted on 02/08/2023 3:43:48 PM PST by Carriage Hill (A society grows great when old men plant trees, in whose shade they know they will never sit.)
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To: Carriage Hill

I’m not transitioning, I am married to a babe… she’s still hot!


12 posted on 02/08/2023 3:48:03 PM PST by Shady (The #JihadJunta: "We are now a nationThat of Men, Not of Laws. You are not as equal as we are...")
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To: ConservativeMind

Take a look at “Calroy Health Sciences Arterosil HP Professional” on Amazon. It has just about everything in it except rhamnan sulfate. Maybe the compound present in seaweed or something.


13 posted on 02/08/2023 3:59:21 PM PST by steve86 (Numquam accusatus, numquam ad curiam ibit, numquam ad carcerem™)
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To: Carriage Hill

also used for women who have hair problem due to things like malfunctioning adrenal glands.

Taking this drug with HCTZ balances out side effects of both so said an endo doctor.


14 posted on 02/08/2023 4:00:17 PM PST by RummyChick
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To: Paladin2

so is that good or bad?


15 posted on 02/08/2023 4:00:51 PM PST by RummyChick
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To: RummyChick

It’s BAD if one wants to drive for 12 hr on a given day.

I just stop taking it two days in advance.

For day by day heart health management, it’s totally optional.

I think there is only a mild correlation with extending life.


16 posted on 02/08/2023 4:47:23 PM PST by Paladin2
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To: steve86

The main ingredient is “MonitumRS.”

That “RS” is rhamnan sulfate. It is an extract that is patented.


17 posted on 02/08/2023 5:25:08 PM PST by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind

Thanks, so I guessed right it was the seaweed!


18 posted on 02/08/2023 5:42:02 PM PST by steve86 (Numquam accusatus, numquam ad curiam ibit, numquam ad carcerem™)
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To: Shady

I was on it for a year, after cardiac problems. but my RN-NP took me off — I needed a training bra — LOLOL!


19 posted on 02/08/2023 5:44:31 PM PST by Carriage Hill (A society grows great when old men plant trees, in whose shade they know they will never sit.)
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To: ConservativeMind

I wonder why they feel the need to add so many other ingredients if the RS is so effective? Also, I want to compare dosages used in the studies vs. the retail capsule. Sometimes you find a research dosage is far in excess of an OTC dosage.


20 posted on 02/08/2023 5:54:55 PM PST by steve86 (Numquam accusatus, numquam ad curiam ibit, numquam ad carcerem™)
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