Gastroesophageal reflux disease causally linked to lung cancer

Medical Xpress / HealthDay / Cancer Medicine ^ | Dec. 30, 2022 | Elana Gotkine / Lin Li et al

[ConservativeMind]

Gastroesophageal reflux disease (GERD) is causally associated with lung cancer risk, according to a study.

Lin Li and colleagues employed a two-sample Mendelian randomization (MR) approach to examine the causal relationship between GERD and lung cancer. Independent single nucleotide polymorphisms that were highly linked to GERD were identified in a sample of 129,080 GERD patients. Data from genome-wide association studies were used to assess outcomes for lung cancer, including squamous cell lung cancer (LUSC) and lung adenocarcinoma (LUAD) in 11,348 patients. To examine the potential causative association between GERD and risk for lung cancer, three MR statistical techniques were used.

The researchers found that based on the main inverse variance weighted (IVW) method, GERD substantially increased lung cancer risk (odds ratio, 1.37); this was also supported in weighted median and MR-Egger analyses. Similar causal relationships were seen between GERD and LUSC and LUAD (odds ratios, 1.56 and 1.45, respectively) using IVW estimates. In some studies, potential heterogeneity was observed; however, random effect IVW was not violated by the heterogeneity, indicating the robustness of the causal effect.

"This study bolstered the case for a genetic link between GERD susceptibility and lung cancer," the authors write. "Considering the high mortality and morbidity associated with lung cancer patients, it is of significance to recognize and control the risk factor of GERD for lung cancer in order to decrease its prevalence."

[ConservativeMind]

I’d say it’s a strong association, but seems probable (no pun intended).

[ConservativeMind]

The “Take Charge Of Your Health” Ping List
This high volume ping list is for health articles and studies which describe something you or your doctor, when informed, may be able to immediately implement for your benefit.

Email me to get on either the “Common/Top Issues” (20 - 25% fewer pings) or “Everything” list.

[musicman]

BTTT!!!

[ProtectOurFreedom]

There is so much advanced math and statistics in medicine. I’ve never heard of any of these bio-statistical methods.

If it is genetic, does “recognize and control the risk factor of GERD for lung cancer in order to decrease its prevalence” make any sense?

[Savage Beast]

Just don’t forget to take that Omeprazole!

[montag813]

Just don’t forget to take that Omeprazole!

Worst stuff ever. Avoid! Most people with GERD just need to lose weight and change what they eat and when they eat.

[Tolerance Sucks Rocks]

You could get lung cancer eating those hot wings all the time!

Here, eat some bugs instead . . .

[wally_bert]

In my case as a very long time sufferer of GERD, Prilosec was its own food group to me.

Almost nothing worked and what little seemed to didn’t last long.

I also suffered from severe diverticulitis and on Jan 4 I almost cashed in my chips because of it.

A few weeks I came home still weak and tired but I didn’t need Prilosec and haven’t touched one since.

One of the medical minds thought Prilosec was masking some kind of infection.

My blood work was always clean though.

[Revel]

So the BS cancellation of Ranitidine is what actually causes cancer.

[Bonemaker]

"In some studies, potential heterogeneity was observed; however, random effect IVW was not violated by the heterogeneity, indicating the robustness of the causal effect."

[telescope115]

First Zantac, then Prilosec, then omeprazole when I found it was cheaper than Prilosec. The doc. had me on Nexium for a while, but it’s just rebranded Prilosec. Still on omeprazole. Gotta have it, and I’ve been on it for a very long time.
I have Ulcerative Colitis, coming up on 29 years and counting. Omeprazole is just one of the meds I’m taking. 5 prescription medications…

[wally_bert]

After a long and mostly disappointing year partly to a doctor who did nothing except string me along for months, I got my repair surgery after getting a new surgeon that cared.

Now I am off all medications for the first time in decades.

[markman46]

I didn’t need to loose weight and change the way I eat for the GERD to go away, I needed a Nissan procedure done to stop the reflux.

[steve86]

Nexium is not Prilosec.

Nexium = Esomeprazole

Prilosec = Omeprazole

[telescope115]

I read a paper written by a doctor once, saying they were the same.
I guess he was wrong, and I stand corrected.👍

[telescope115]

Wonderful! Good health to you!

[wally_bert]

Very kind.

For the first few months of last year, I was questioning my own existence and the light at the end of the tunnel seemed way off in forever.

I could barely walk for a couple of weeks among other things.

Somehow I managed to keep going.

[Tunehead54]

Did they tie down the bottom of your esophagus - forget what the procedure is called but my lady has GERD that meds don’t seem to help. Any answer would be appreciated ...

Charlie

[wally_bert]

I had a Hartmann Reversal, lost a few feet of large intestine and while I was opened up my appendix was removed. Nothing above was worked on.

One thing I found that did help with GERD was gluten free food. This was several months prior to the diverticulitis blowout.

The thinking from one of the good medical minds is that Prilosec was covering up an existing infection.

Hope trying gluten free helps.

[Tunehead54]

Thanks for responding. I have no allergies at all that I know of but my wife gets skin conditions and who knows maybe its gluten but as a diabetic she does almost zero carbs, no breads, no pasta, no milk products - - a ridiculous diet you’d think but its all based on a bookshelf full of he research.

10 years on insulin and now 15 years off with good sugar control - diet & exercise. But something is changing so who knows - I know she’s got GERD maybe its gluten related.

Again, thanks.

Charlie