[ConservativeMind]

You don’t always want extra oxygen.

[ConservativeMind]

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[Seaplaner]

You don’t always want extra oxygen.

True, this.

Otherwise, we wouldn't be supplementing with a bunch of antioxidants.

(Yes, I know, oxidation does not always involve oxygen, we're really talking loss of electrons.)

[Radix]

I do not believe a word of this.

[Georgia Girl 2]

This sounds like a bunch of BS to me. They are putting people in hyperbaric chambers for cancer, Lyme disease etc with good results.

During my second cataract surgery they gave me a little too much oxygen because of my asthma. I had a bad sore throat for a day. No big deal.

[RummyChick]

So if you get the TIVA method of anesthesia.. vein versus mask..do they still do oxygen mask on you..seems like they would still need to be Able to regulate.

[pepsionice]

These people who get serious Covid and end up in hospitals....are often seen getting ‘extra’ oxygen. Makes one wonder if their ‘long-Covid’ problems don’t all lead back to this same issue.

[Steve Van Doorn]

said, "Giving patients excess levels of oxygen during surgery"

They are really slow to figure this out.
Maybe in 10 years they will figure out Vit-B1 thiamine intravenously adds oxygen without passing through the lungs.

[olivia3boys]

I’ve had 5 major surgeries. Before my most recent one (an appendectomy) a CAT scan/MRI (forgot which) report casually noted “evidence of lung damage” and referred to prior surgeries and anesthesia as the likely cause (none of my surgeries had anything to do with my lungs or were near the lungs at all).

[caddie]

Kidney, heart, and lung damage ASSOCIATED with increased oxygen concentration does not necessarily mean that excess oxygen CAUSES these things. This is certainly the case here.

Acutely ill, overweight patients, and patients with cardiovascular disease (prone to MI and stroke) are generally given higher concentrations of oxygen as a rule. Not to be reckless, but to ensure adequate oxygen saturation.

In this study, fully one half of patients were classified preop as ASA category 3, meaning "severe preexisting systemic disease". This factor was not adequately controlled in the study.

The kind of surgery makes a huge difference in how much oxygen is required to maintain good saturations; it was not controlled here.

The measures of "kidney damage" and "myocardial damage" are too sensitive, poorly controlled (meaning only the sickest patients had postoperative creatinine and troponin drawn), and, as far as this paper tells us, the transient postoperative increases in creatinine and troponin were unrelated to long term kidney or heart damage.

Lastly, you always need to weigh the risk versus the benefit of a therapy.

It has been shown, for instance, that using high (excess) oxygen concentrations is very effective at reducing postoperative surgical wound infections. If you've ever seen or had a postoperative wound infection, you know that it is a big deal.

That finding was via a controlled prospective study (N Engl J Med 2000; 342:161-167), not a retrospective study like this one.

This study opens a lot of possibilities for further, well-controlled, prospective, hopefully blinded, studies. But it does not show that 'excess oxygen', as they define it, is necessarily harmful.

[blueplum]

IIRC, excess O2 can dry out the coating on avoili, a fatty substance called the pulmonary surfacant that keeps avioli from collapsing. (also dried out by smoking)

related, from 2016:
Too Much Oxygen: Hyperoxia and Oxygen Management in Mechanically Ventilated Patients
https://pubmed.ncbi.nlm.nih.gov/26820270/