Posted on 10/07/2022 12:23:35 PM PDT by ConservativeMind
Glomerular filtration rate (GFR) is the best overall index of kidney function. Normal GFR varies according to age, sex, and body size, and declines with age. The National Kidney Foundation recommends using the CKD-EPI Creatinine Equation (2021) to estimate GFR.
NKF and the American Society of Nephrology have convened a Task Force to focus on the use of race to estimate GFR.
(Excerpt) Read more at kidney.org ...
I did a sanity check against the National Kidney Foundation website’s current calculator. I get the same eGFR if I do not use the “Adjust For Body Surface Area” set of inputs. When I put in my height and weight and selected that I had a standard assay, my eGFR shot up over 30 points higher!
You see, the normal eGFR formula is a poor estimator of kidney function, yet, it’s the most common number used to tell us how bad our kidneys must be. It’s apparently far from true.
I have a Cystatin C test coming in today or tomorrow and I will see what it adds to the mix, as it could be more accurate.
Please plug in the numbers that matter to you and see what your CKD-EPI creatinine equation (2021) results are.
Thanks for the article. I’ll show this to my kidney specialist but I’m sure she’s aware of this already.
My eGFR has been fluctuating for the past few years. The last one went up and the kidney doctor was mildly surprised.
Major changes from a year ago include taking GlyNAC, Taurine, and Urolithin A for the past 3.5 months. I also use Pantethine now, for most of the past year, and I’ve been generally watching my carbs more closely, getting between 30-70 grams of net carbs a day.
i dont understand this calculator. I have had several kidney tests over the past year. They report it with race and without race but they do not report it using height and weight. I was shocked at how much height and weight changes it.
Does anyone else get their EGFR with weight and height included..and is it suppose to be and Drs just arent doing it.
I am a little upset at this notion of height and weight because not one single Dr..including kidney and adrenal doctors have indicated that I have a problem..which I do as per calculator before you even include the height and weight which makes it even worse
I just did a quick read on GlyNac. “GlyNac is thought to work because it contains both glycine and cysteine, amino acids needed for glutathione production. Older adults have been shown to have lower levels of both of these amino acids.”
I’ve been taking glutathione since the monomania of covid set in. I wonder if taking glutathione directly is different that taking GlyNac. I’d like to know your thoughts.
“Choosing “No” will calculate an indexed eGFR value, standardized to a body surface area of 1.73m2 (units: mL/min/1.73m2)
Assessment for CKD staging and CKD progression should generally be assessed using the indexed eGFR value.”
Our cells are made to produce Glutathione, this powerful antioxidant, directly where it's needed, but it needs those building blocks that we stop making, as we age. You see, it wasn't really known, but all of those “conditional” amino acids we can make, if we don't get them from foods? Well, we stop making enough and very key processes break down.
How do you get the Glutathione making process restarted? Take equal amounts of Glycine and Cysteine (NAC), at least 1,200 mg of each a day, seemingly no more than 600 mg of each at a time. Take them together. They migrate throughout your body and into cells exactly where needed and your cells work right, again.
The same thing is strangely true of Taurine, which we used to make, but supplementing just 500 mg of Taurine powder three times a day made Superoxide Dismutase (SOD), another powerful antioxidant, increase over 20% in our bodies in a study.
Who would have thought these were no longer properly being made by our bodies?
Take the GlyNAC and the Taurine separate from other foods, to better assure they get where they are supposed to go, and are not brought into some protein function. I do take GlyNAC with the Taurine, though.
Thank you. Any opinions on CoQ10 or ubiquinone?
We take 100 mg a day of ubiquinone.
The way I read #6 in the FAQs, we have to index to body size to properly compute kidney disease.
https://www.kidney.org/sites/default/files/441-8491_2202_faqs_aboutgfr_v5.pdf
this seems to be the right way to read #6. But compare that to the following that seems to indicate to use the index of the standardized body mass for determining CKD and use the actual height and weight for dosing purposes
“Choosing “No” will calculate an indexed eGFR value, standardized to a body surface area of 1.73m2 (units: mL/min/1.73m2)
Assessment for CKD staging and CKD progression should generally be assessed using the indexed eGFR value.
Choosing “Yes” will bring up fields to input height and weight. A non-indexed eGFR value (i.e. adjusted for the patient’s body surface area) will be calculated (units: mL/min).
Drug dosing decisions should generally be based on non-indexed eGFR value.
Exception: Using non-indexed eGFR in morbidly obese patients can result in a large overestimate of measured GFR and potential for overdosing.”
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