Posted on 09/22/2022 9:17:15 PM PDT by ConservativeMind
In a large clinical trial that directly compared four drugs commonly used to treat type 2 diabetes, researchers found that insulin glargine and liraglutide performed the best of four medications to maintain blood glucose levels.
While there is general agreement among health care professionals that metformin combined with diet and exercise is the best early approach in diabetes care, there is no consensus on what to do next to best keep high blood glucose in check.
The study enrolled 5,047 people with type 2 diabetes who were already taking metformin. Three groups took metformin plus a medicine that increased insulin levels, sitagliptin, liraglutide, or glimepiride. The fourth group took metformin and insulin glargine U-100, a long-acting insulin.
After an average of four years of follow-up, the study found that participants taking metformin plus liraglutide or insulin glargine achieved and maintained their target blood levels for the longest time compared to sitagliptin or glimepiride. This translated into approximately six months more time with blood glucose levels in the target range compared with sitagliptin.
However, none of the combinations overwhelmingly outperformed the others. Although average blood sugar levels decreased during the study, nearly three quarters of all participants were unable to maintain the blood glucose target over four years, underscoring the difficulty in maintaining recommended targets in many patients with type 2 diabetes.
The study also looked at the treatments' effects on developing diabetes-related cardiovascular disease. Researchers found that participants in the liraglutide group were least likely to experience any cardiovascular disease overall compared to the other groups.
On average, participants in all treatment groups lost weight. Over four years, people in the liraglutide and sitagliptin arms lost more weight (an average of 7 and 4 pounds, respectively) than the glargine and glimepiride arms (less than 2 pounds).
(Excerpt) Read more at medicalxpress.com ...
There is absolutely no substitute for reducing your carbs and getting more exercise. You have to treat diabetes at its root cause level.
Insulin glargine is not a drug, it’s synthetic insulin produced by recombinant DNA technology. Injected, as all forms of insulin must be. Very effective, although dosage must be closely regulated according to your food intake.
something sets off diabetes and its not just weight because personally I know lots of very overweight people who are sedentary as well who have no blood sugar issues...
but our health care industry likes to make big money so actually just curing people would cut profits...
Insulin glargine = Lantus
Every single article regarding diabetes puts focus on weight loss. What if you are not over-weight and develop diabetes? Every diabetes diet recommendation causes more weight loss which is not healthy either.
Glargine and liraglutide. Do you gargle them or what?
Insulin glargine = Basaglar
My A1c is 5.6
They’re both injectables.
Brand names Victoza and Basaglar/Lantus
I use both, and as noted above my A1c is 5.6. Anything below 7.0 is regarded as good, 7.0 is the “goal” for a diabetic.
The average A1c for healthy non-diabetics is 5.2. That’s where I want to be.
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