Research links red meat intake, gut microbiome, and cardiovascular disease in older adults

Medical Xpress / Tufts Univ. /JAMA Network Open / Arteriosclerosis Thrombosis and Vascular Biology ^ | August 1, 2022 | Amanda M. Fretts et al

[ConservativeMind]

Does eating more red and processed meat raise the risk of cardiovascular disease? Despite intense study, the impact of animal source foods on atherosclerotic cardiovascular disease (ASCVD) is vigorously debated, and effects remain unclear.

A study quantifies the risk of ASCVD associated with meat intake and identifies underlying biologic pathways that may help explain this risk. The study shows higher meat consumption is linked to higher risk of ASCVD—22 percent higher risk for about every 1.1 serving per day—and that about 10 percent of this elevated risk is explained by increased levels of three metabolites produced by gut bacteria from nutrients abundant in meat. Higher risk and interlinkages with gut bacterial metabolites were found for red meat but not poultry, eggs, or fish.

Several blood biomarkers were measured, including levels of the gut-microbiome generated trimethylamine N-oxide (TMAO) and two of its key intermediates, gamma-butyrobetaine and crotonobetaine, derived from L-carnitine, abundant in red meat.

"Interestingly, we identified three major pathways that help explain the links between red and processed meat and cardiovascular disease—microbiome-related metabolites like TMAO, blood glucose levels, and general inflammation—and each of these appeared more important than pathways related to blood cholesterol or blood pressure," said author, Dariush Mozaffarian. "This suggests that, when choosing animal-source foods, it's less important to focus on differences in total fat, saturated fat, or cholesterol, and more important to better understand the health effects of other components in these foods, like L-carnitine and heme iron."

In May, researchers reported that TMAO and related metabolites in older adults are positively associated with a higher risk of death whether deaths were related to cardiovascular disease or another disease. Participants with the highest levels of plasma TMAO and its biomarkers had a 20 to 30 percent higher risk of death compared with those having the lowest levels.

[ConservativeMind]

There continues to be conflicting perspectives on what is the apparent concern with TMAO.

This research dovetails with prior research from the Cleveland Clinic, which found TMAO-producing bacteria were temporarily silenced when diners ate their red meat with olive oil or balsamic vinegar.

[ConservativeMind]

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[Fungi]

TMAO.Is that similar to PDQ BACH?

[867V309]

I quit listening to dietary “research” when the government said eggs and butter were bad but margarine (trans-fats) were good.

[cranked]

Propaganda sanctioned eat more bugs, 3D printed food, synthetic food, etc.

[logi_cal869]

“Does eating more red and processed meat raise the risk of cardiovascular disease?”

---

The question biases the outcome, and their citations of research criteria validates that statement.

Bad science. More ‘M&M’.

[indthkr]

gut-microbiome - bump for later....

[moonhawk]

I would think they would attempt to distinguish red meat from processed meat. Not the same thing.

[TTFX]

Men who.consume chocolate or meat consume more iron than they need.

The heart, liver, and pancreas store iron. Excess iron damages these organs.

Donating blood every two years prevents excess iron.

If a person’s blood ferritin is less than 70 ng/ml, he is deficient in iron.

[noiseman]

After what we’ve been through with Fauci, the CDC, FDA, etc., don’t ever forget the editorial written a few years ago by none other than the editor of the New England Journal of Medicine. He wrote it because he was so fed up with fraud and incompetence in the medical research bureaucracy. His primary claim was that 95% of ALL medical “research” papers are WRONG. He said that the rush to publish first in order to chase lucrative research grants had thoroughly corrupted the entire process, and that most conclusions were simply incorrect. Which likely explains things like claims that certain foods will kill you, only to have a later study conclude that these “killer foods” are actually health foods, followed a few years later by another reversal to “nope, gonna kill ‘ya”, and back again, ad infinitum.

At this point, my default position is to be extremely skeptical of any claim made by the medical establishment. Recent history, if nothing else, has proven them to be incredibly untrustworthy and self-serving.

[noiseman]

Men who.consume chocolate or meat consume more iron than they need.

But wait a minute, that would contradict research that has claimed for quite a while now that chocolate is GOOD for cardiovascular health. This is exactly the problem I mentioned in my earlier post. Medical “research” has become so corrupted by grant money that almost nothing they claim can be trusted.

Need proof? Look no further than the recent revelations about the FRAUD that was committed in the foundational “research” that guided for decades not only the general medical understanding about what causes Alzheimer’s disease, but also the standard treatment for it. Now we find out that ALL OF IT WAS BASED UPON A LIE! The “researchers” had flat out falsified the data, and their conclusions have now been found to be completely wrong! So now we’re back to square one with Alzheimer’s and drugs to treat it. And that’s not all. We also recently had the release of a research paper that claimed that, contrary to the long-held belief that clinical depression is caused by low seratonin levels, that seratonin does not affect depression at all. This also means (if true) that antidepressants do nothing therapeutic (though they can have very real adverse effects). Of course, in the current corrupt and unreliable medical atmosphere, who know if this “research” is correct either? It’s become a total clown show, but unfortunately these clowns have people’s lives in their hands.

So the next time they tell you something like, “Red meat causes heart disease”, remember how cock-sure the entire industry was that “sticky plaques” caused Alzheimer’s, or that low seratonin caused depression, or for that matter that mRNA COVID “vaccines” worked.

[TTFX]

Chocolate would help until it causes excess iron. Consuming chocolate won’t cause excess iron if you remove iron from your body.

You shouldn’t believe statements about health without evidence.

You can evaluate statements about health by reading about experiments. You also have to evaluate whether the publication you are reading is fraud.

I think the stataments I made are indisputable. Nobody serious denies that if one consumes more iron than one needs, the body accumulates it.

[SpokeshaveReturns]

I stopped eating red meat and processed foods 6 months ago....seeing my cardiologist next week...will report on it .......spokeshave at 80.

[Gene Eric]

My appetite for read meat has declined in my ‘mature’ years. It’s not that I don’t enjoy it any more, but I’m no longer craving it.

Another interesting research find.

Despite the decades of orthogonal cause & effect dietary science, the consumer may eventually learn about (and appreciate) enjoyable, non-destructive sustenance. And that can certainly include read meat, eggs, butter, dairy...

[Gene Eric]

Good point, but honest research is helping to set the record straight.

A free society is best occupied by those who realize it’s a crapshoot, but also make the time to get into the details.

We (baby-boomers) were raised to trust both industry & govt.

[dennisw]

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[dennisw]

“Replication crisis”

The replication crisis (also called the replicability crisis and the reproducibility crisis) is an ongoing methodological crisis in which it has been found that the results of many scientific studies are difficult or impossible to reproduce. Because the reproducibility of empirical results is an essential ...See more

[cherry]

cereal was good then bad.....whole wheat good, then bad...eggs the same...salt the same...coffee bad/good/bad/good....

[Nifster]

But why did they say red meats and processed meats? Fundamentally they’re talking about beef and I suppose salami and pepperoni. They did not include bison or pork in the study

If one is luck ng on a tight budget chicken is consumed much more frequently than beef

What I take away is that I can forget about cholesterol and Eat More Chikin!!!!

[Nifster]

More like Gavotte for Bach

But still nicely played