Posted on 08/02/2022 8:24:23 PM PDT by ConservativeMind
For patients with COVID-19-related olfactory dysfunction (OD), the clinical benefit of theophylline added to saline nasal irrigation (SNI) is inconclusive, according to a study published online July 7 in JAMA Otolaryngology-Head & Neck Surgery.
Shruti Gupta, M.D., from Washington University School of Medicine in St. Louis, and colleagues examined the efficacy and safety of theophylline versus placebo added to SNI for COVID-19-related OD in a phase 2 randomized clinical trial. Participants with OD persisting for three to 12 months following COVID-19 infection were recruited and randomly assigned to receive saline sinus rinse kits and bottles of identical-appearing capsules with either 400 mg of theophylline (treatment) or 500 mg of lactose powder (control; 26 and 25 patients, respectively).
The researchers found that at the end of treatment, at least slight improvement in the Clinical Global Impression Improvement scale was reported by 59 percent in the theophylline arm compared with 43 percent in the placebo arm. Between baseline and six weeks, the median difference in the University of Pennsylvania Smell Identification Test (UPSIT) change was 3.0 and 0.0 for participants in the theophylline and placebo arms, respectively; the change in UPSIT scores was not significantly different between the groups. A change of 4 or more points in UPSIT scores from baseline to six weeks occurred in 50 and 26 percent of participants in the theophylline and placebo arms, respectively.
"Clinically meaningful benefits in olfactory function for patients with chronic COVID-19-related OD are suggested by subjective assessments but are not definitively demonstrated," the authors write.
(Excerpt) Read more at medicalxpress.com ...
wonder if it woudl help for zinc-caused smell loss? (There was an excellent cold and flu product awhile back called Zicam with zinc in it which caused a couple of people i guess to lose their smell, so the product was taken off the market)
I used those Zicam nasal swabs, as did my wife, and they worked really well.
Yes, zinc did something to some peoples’ scent receptors.
Nope.
The only logical reason for persistent loss of smell is viral infection of the olfactory epithelium. I know: I have real data.
The epithelium constantly regenerates and only a pathogen - and/or its effects - would interfere with that process. My experience to-date is that the effect is temporary. I believe the virus goes latent in the body and may answer many of the mysteries behind unexplained illnesses, including ‘long covid’.
This is bad science absent pathology of sinus tissue for affected patients...something I’m not aware has been accomplished anywhere to-date.
No wonder, considering this quote at the opening of the VERY brief piece:
“For patients with COVID-19-related olfactory dysfunction (OD), the clinical benefit of theophylline added to saline nasal irrigation (SNI) is inconclusive...”
Just more ‘M&M’.
yeah it was good stuff- best otc meds i’d ever used for flues really-
The epithelium constantly regenerates
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I hope so
I haven’t been able to smell anything since c19 in Nov 2019.
Still waiting for it to regenerate.
?
I do normal nasal irrigation to help be less congested and it seems to help me smell better...because, well, it makes me less congested.
Would consider the posting of the information you possess to be a blessing for a friend, who is dealing with such “long-haul-covid” symptoms of scent and taste gone haywire - along with many other symptoms.
Having visited said friend today, heart is hurting for same. Said friend is one of four persons in same household, two married couples, who all became ill c-19 in April of 2021. Two of the four were vaxxed, this friend not one. Vaxxed couple have never been right or in satisfactory health since. Candidly believe that the vaxxed infected the household.
Thanks for any information assistance. N.
See FReepmail.
My theories served to return smell to both my boy and his buddy. It was a trial & error, multi-step process. Hardly scientific, but the results are definitely conclusive in labeling loss of smell as not permanent if the cause is addressed.
I believe the same of ‘long covid’ but, regrettably, I don’t personally know anyone who has the condition. Compared to ‘lifestyle disease’ this should be academic.
https://freerepublic.com/focus/chat/4082272/posts?page=82#82
I’d ask if your friend has ever engaged antivirals such as Ivermectin. Regrettably, I’ve done no research on the subject of ‘long covid’ because I’ve had too many distractions and it wasn’t a personal concern, but this is right up my alley.
Would consider the posting of the information you possess to be a blessing for a friend, who is dealing with such “long-haul-covid” symptoms of scent and taste gone haywire - along with many other symptoms.
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Note that groups at higher risk for the wuhan coronavirus had more stored iron.
If one had a severe case, it’s likely one has excess iron. One can make a stored iron blood test to evaluate that. If one has unnecessary iron, one can remove it by removing blood.
If a person’s blood ferritin is less than 70 ng/ml, he is deficient in iron.
I CURRENTLY have covid but no loss of smell. Foods are tasting a bit different tho.
I’m on day 5, lots of symptoms but so far, managable. Thank God for immodium!! And tylenol.
Get plenty of rest- stay away from paxlovid as it causes “rebound covid”. We found out the hard way. Was sick for around 8 days, got better for a few days, then wham, got sick again- doctors didn’t warn about paxlovid causing rebound covid. We even took ivermectin at same time, still,ended up witn rebound covid. It was bad, but not the worst flu we’ve ever had. Just exhausted us all really.
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