Posted on 07/20/2022 8:25:24 AM PDT by ConservativeMind
Statins can effectively lower high cholesterol, and many individuals take rosuvastatin, one member of this drug class. New research based on patient health records and published in Journal of the American Society of Nephrology suggests that rosuvastatin, especially at higher doses, may have damaging effects on the kidneys.
Reports had linked rosuvastatin with signs of kidney damage—hematuria (blood in the urine) and proteinuria (protein in the urine)—at the time of its approval by the U.S. Food and Drug Administration, but little post-marketing surveillance exists to assess real-world risk. To investigate, Jung-Im Shin, MD, Ph.D. (Johns Hopkins Bloomberg School of Public Health) and her colleagues analyzed electronic health record data for 152,101 new users of rosuvastatin and 795,799 new users of another statin called atorvastatin from 2011–2019.
Over a median follow-up of 3.1 years, the team identified hematuria in 2.9% of patients and proteinuria in 1.0% of patients. Compared with atorvastatin, rosuvastatin was associated with an 8% higher risk of hematuria, a 17% higher risk of proteinuria, and a 15% higher risk of developing kidney failure requiring replacement therapy such as dialysis or transplantation. Risks of hematuria and proteinuria were higher with a higher dose of rosuvastatin. Also, among patients with advanced kidney disease, 44% were prescribed a higher dose of rosuvastatin than the US Food and Drug Administration recommends for individuals with poor kidney function.
"We observed a higher risk of hematuria, proteinuria, as well as kidney failure with rosuvastatin use and similar cardiovascular benefits between the rosuvastatin and atorvastatin groups," said Dr. Shin. "Because rosuvastatin may cause proteinuria and hematuria, especially with high dose, high dose rosuvastatin may not merit the risk—even if small—particularly for patients with advanced kidney disease."
(Excerpt) Read more at medicalxpress.com ...
Did find these recent research links on Google Scholar re Apple Cider Vin and reduction of Cholesterol.
https://scholar.google.com/scholar?hl=en&as_sdt=0%2C38&q=cholesterol+apple+cider+vinegar&btnG=
Pick your research article !
I like Apple Cider!
Must get some now!.................
Ping
Me too.
That’s what I take but low dose 10mg day thanks for the info 🤪
“ I stopped taking my statins a while ago......................”
I wanted to but doctor told me this month during wellness check my cholesterol levels weren’t low enough to do that on the blood tests.
So did mine..........................
“ Mostly that is true, but some people have genetic defects that they cannot overcome with diet and exercise...................”
Mine seems to be from my father - my weight is good and I exercise a lot to avoid pre diabetes
I cut my dose by 50% after discovering that concomitant calcium channel blocker use raises serum level by a significant amount.
Atorvastatin does when it is taken with several common prescription and OTC drugs....causing a build up of high levels of atorvastatin. If you need both drugs, they usually tell you to monitor for certain symptoms.
If you are taking it, be sure to use a drug interaction checker.
Several MD’s that I worked with took a statin every other day or every three days to get some of the beneficial effects. They said it was sufficient to lower cholesterol and help clear the circulatory system.
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