Posted on 07/20/2022 8:25:24 AM PDT by ConservativeMind
Statins can effectively lower high cholesterol, and many individuals take rosuvastatin, one member of this drug class. New research based on patient health records and published in Journal of the American Society of Nephrology suggests that rosuvastatin, especially at higher doses, may have damaging effects on the kidneys.
Reports had linked rosuvastatin with signs of kidney damage—hematuria (blood in the urine) and proteinuria (protein in the urine)—at the time of its approval by the U.S. Food and Drug Administration, but little post-marketing surveillance exists to assess real-world risk. To investigate, Jung-Im Shin, MD, Ph.D. (Johns Hopkins Bloomberg School of Public Health) and her colleagues analyzed electronic health record data for 152,101 new users of rosuvastatin and 795,799 new users of another statin called atorvastatin from 2011–2019.
Over a median follow-up of 3.1 years, the team identified hematuria in 2.9% of patients and proteinuria in 1.0% of patients. Compared with atorvastatin, rosuvastatin was associated with an 8% higher risk of hematuria, a 17% higher risk of proteinuria, and a 15% higher risk of developing kidney failure requiring replacement therapy such as dialysis or transplantation. Risks of hematuria and proteinuria were higher with a higher dose of rosuvastatin. Also, among patients with advanced kidney disease, 44% were prescribed a higher dose of rosuvastatin than the US Food and Drug Administration recommends for individuals with poor kidney function.
"We observed a higher risk of hematuria, proteinuria, as well as kidney failure with rosuvastatin use and similar cardiovascular benefits between the rosuvastatin and atorvastatin groups," said Dr. Shin. "Because rosuvastatin may cause proteinuria and hematuria, especially with high dose, high dose rosuvastatin may not merit the risk—even if small—particularly for patients with advanced kidney disease."
(Excerpt) Read more at medicalxpress.com ...
Rosuvastatin’s brand name is Crestor.
I stopped taking my statins a while ago......................
Link is to an article on Crohn’s Disease.
"Compared with atorvastatin, rosuvastatin was associated with an 8% higher risk of hematuria, a 17% higher risk of proteinuria, and a 15% higher risk of developing kidney failure"
Thank you!
Correct link:
https://medicalxpress.com/news/2022-07-real-world-links-rosuvastatin-kidney.html
Here’s an on-point link to the same information: https://www.eurekalert.org/news-releases/958785
Correct, there is no added risk with atorvastatin beyond the standard risk.
I stopped taking my statins a while ago......................
————————-
Are you dead yet ?
My doc is freaking that I’ve quit Rosuvastatin (caused awful joint and muscle pain) Had same problem with Atorvastatin.
No, thank you. The information that you post several times a day regarding health issues is invaluable, and I am sure that it is, has been, and will continue to be life-saving for many here. I noticed this particular article because that’s the statin that my wife takes, and she is both diabetic and has a family history of kidney issues. I think we’re going to be having a VERY frank conversation with her doctor before too long. Again, thank you for everything that you do with this list.
This has been a know issue for decades that some people do not tolerate some of the statins and can have an impact on their kidney and liver function. Which is why doctors have you come back after 6-8 weeks to not only check your lipids, but kidney and liver functions as well.
Take CoQ10, as a statin removing it is the reason for muscle pain. Oh, yeah, minor point: the heart is a muscle. So the ironic result of statins, which absolutely do reduce cholesterol, is that people are dying of congestive heart failure with much cleaner arteries. There are basically no studies that prove an extension of wife from taking statins, it simply addresses one problem in a very effective way, but the entire industry has purposely ignored the very real downside. Mark at one point was in the process of bringing a combination of its premiere statin drug and CoQ10 through the FDA approval process, but at some point one of their lawyers must’ve said that by doing so they were admitting that the Staten by itself caused harm, so they pulled the application.
there are trade offs here.
crestor significantly reduces inflammation whereas lipitor does not.
It is far better to get healthier than to rely on a drug to cover for you.
Getting healthy has no negative side effects!
Uh, extension of LIFE.
No, I don’t have a rack at home to extend my wife. 😜
There are many ways to reduce inflammation, such as with antioxidants.
There aren’t many ways to replace a kidney.
Mostly that is true, but some people have genetic defects that they cannot overcome with diet and exercise...................
I take CoQ10 with crestor because my understanding is that the statins reduce CoQ10. So you have to supplement.
Its not clear to me exactly what it is that CoQ10 does or why a statin reduces it.
stop eating wheat
I usually go to the Google Scholar website to get (great) research articles on many subjects.
Weird, when typing in Cholesterol, None of the research articles are recent.
Guess I’m not surprised.
Found one article from 2018 on tree nuts and cardio disease prevention
https://link.springer.com/article/10.1007/s11883-018-0749-3
Not typical for Google Scholar which usually provides up to date research articles where regular Google Search only nets links of advertisers
Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.