Posted on 06/03/2022 4:36:03 PM PDT by libh8er
A recent Phase 1 clinical trial has administered a dose of an experimental anticancer drug called CF33-hNIS, or Vaxinia, to the study’s first participant. This novel therapy involves using an oncolytic virus, a type of virus that can infect and kill cancer cells without harming healthy tissue.
Vaxinia, a genetically modified smallpox virus, has been previously shown to be effective against a broad range of cancers in laboratory and animal models. This clinical trial conducted by City of Hope, a cancer research and treatment institute in the United States, in collaboration with Imugene, a biotech company in Australia, will test the novel oncolytic virus in cancer patients with advanced solid tumors.
Laboratory studies suggest that Vaxinia may be more effective than the previous generation of oncolytic viruses in reducing the size of tumors, making this therapy especially promising.
Dr. Yuman Fong, the chair of the Department of Surgery at City of Hope, told Medical News Today, “The particular importance of CF33/ Vaxinia is that this virus is designed to target all types of cancers. It is one of the first of a new generation of therapeutic viruses that would be much more potent than prior viruses, and it is potentially more selective for cancer while able to spare normal tissues.”
Leslie Chong, the CEO of Imugene, told MNT, “We are keen to revolutionize cancer therapy, and no longer are we satisfied with incremental improvements in survival, we want to cure patients. By making cancer into one disease and having a targeted agent to obliterate it, that’s the holy grail of cancer therapeutics!”
Oncolytic viruses Oncolytic virusesTrusted Source include viruses found in nature or are genetically engineered to selectively infect and replicate in tumor cells.
As oncolytic viruses replicate, they can disintegrate and kill infected tumor cells. When tumor cells burst, they release tumor proteins or antigens, which the immune system recognizes as foreign. The immune response then elicits against these antigens resulting in further death of tumor cells.
Additionally, the immune system’s ability to recognize the tumor cells creates a memory against the tumor antigens, which can help prevent cancer recurrence. Besides providing durable protection, a small dose of oncolytic viruses can be effective against the tumor due to the ability of the virus to replicate and spread in the tumor cells.
Cancer cells express proteins and receptors on their surface distinct from healthy cells that help them evade the immune system, metastasize, and prevent cell death. Oncolytic viruses use these cancer cell-specific proteins and receptors to target them.
Dr. Fong notes, “Interestingly, the same characteristics that eventually make cancer cells resistant to chemotherapy or radiation treatment actually enhance the success of oncolytic viruses, such as CF33-hNIS.”
Moreover, the proteins targeted by oncolytic viruses are often common to a broad range of cancers, making these viruses a versatile tool.
Using Vaxinia to target tumor cells CF33-hNIS or Vaxinia, developed by the researchers at City of Hope is a genetically modified version of the vaccinia or smallpox virus. The researchers have designed CF33-hNIS to enhance its ability to replicate in tumor cells, facilitating a large immune response against the tumor cells.
In addition, the modified vaccinia virus also expresses a protein called human sodium iodide symporter (hNIS), which transports iodide ions into the cells. Thus, tumor cells infected by the virus express hNIS, allowing radioactive iodine uptake.
Imaging techniques such as position emission technology (PET) scans can then be used along with radiolabeled iodine as a dye to help track the distribution of the virus in the body and its effectiveness.
Moreover, hNIS can also help selectively target tumor cells that accumulate radioactive iodine using radiotherapy.
Clinical trial design Previous studies have shown that CF33-hNIS is effective against cell culture and animal models of breast, colorectal, pancreatic, ovarian, and lung cancers. During the Phase 1 clinical trial, researchers will test the safety and tolerability of CF33-hNIS in cancer patients by injecting the virus directly into the blood or the tumor.
Specifically, the trial will include about 100 cancer patients with metastatic or advanced solid tumors who have previously received at least two standard cancer treatments.
Upon successful demonstration of Vaxinia’s safety, the researchers also intend to test treating tumor cells using a combination of this oncolytic virus and another type of cancer therapy called pembrolizumab, an immune checkpoint inhibitorTrusted Source.
Cancer cells tend to express certain checkpoint proteins that prevent their elimination by T cells, a part of the immune system. Immune checkpoint inhibitors are drugs that block such proteins’ action to enhance the immune cells’ ability to kill tumor cells.
Previous dataTrusted Source suggest that CF33-hNIS increases the expression of a checkpoint protein, which can improve the efficacy of immune checkpoint inhibitors, such as pembrolizumab.
“Oncolytic viruses have already been shown in animal models to be as effective as combination therapy with many other immunotherapies, including checkpoint inhibitors and CAR T therapies. We are hoping the CF33/ Vaxinia platform will move rapidly to clinical testing in combinations with these and become effective combination immunotherapies in the treatment of human cancer,” said Dr. Fong.
The researchers also intend to examine the efficacy of this therapy as a secondary outcome throughout this phase 1 trial.
No these geniuses used a GMO version of humanities scrounge aka smallpox what could possibly go wrong. I guess it would be fun to rip around a empty city in the most expensive car I could find while shooting full auto out the windows.
“A recent Phase 1 clinical trial has administered a dose of an experimental anticancer drug called CF33-hNIS, or Vaxinia...”
Vaxinia sounds very familiar to two other words I’ve heard but I can’t quite put my finger on them. I do know that I hold the vaginas pushing the vaccine in the highest level of contempt.
“What could possibly go wrong?”
I think you mean, “What could possibly go Wong?”
Yeah, sure the FDA and big Pharma is going to allow this to proceed if it even looks like it might be moderately successful. CORRUPTION!
but all this is academic --
you are made as good as we could make you."
I think the full name is Sum Ting Wong.
Will be praying for you. The problem is not with the Freepers souls, the problem lies with the Big Pharma’s track record.
In your situation if you can try it, more power to you.
Sorry to hear about your diagnosis.
I agree, if I were terminally ill, I’d try just about anything.
I’ve read about this before. From what I remember, Duke University oncology researchers had some success in treating inoperable brain tumors.
Maybe you’ll be able to get in on a medical trial and have to put up with the gang here forever.
Prayers up for you. You’ve been around for a while. God speed.
I will keep you in my prayers. 🙏
What is the symbol? I would like to check it out. In my younger days I was constantly searching for a penny stock that would make me rich. I never found it and gave up after many losses. I was just unlucky.
You can get oncolytic virus treatment in Cologne, Germany. The IOZK clinic uses a modified Newcastle virus along with localized heat therapy to knock out cancer cells. I went there for three sessions. It is a really nice therapy because you go into the clinic for less than an hour each day, and you have the rest of the day to be a tourist.
Three trips cost us around $90K, we had help from GoFundMe and family. The therapy did not work for my non-cancerous tumor, but it did knock out a huge chunk of skin cancer growing on my nose.
“I have stage 4 lung cancer that has spread to my bones, kidney and liver. I’d definitely try it if possible. The wise cracks about it on this thread break my heart. I thought FReepers had souls.”
I’ve thought many times about what I’d do if I learned that I had life-threatening cancer with little chance to recover. I can’t really say for sure, but in my self-dialogue I always say I’d attempt a long-term fast.
I’ve gone three full weeks before with no food, just water. I might have had a little tea or coffee. I forget. I try to to stick to water and sometimes use water with minerals added. Alkalized water seems to work. But no calories.
Anyway, I’ve never made it longer, but I would try. Currently I have enough excess fat to go a while without any food. A person’s health might affect his or her ability to fast. For example, are there other medical conditions that require medication? Etc.
But the body goes into a powerful healing and cleansing mode after about 3 days with no food. Blood sugar levels should become very stable and low. It boosts autophagy. This leads me to believe that it could force cancer into remission.
You probably have had many people share suggestions to be helpful. Maybe some are and some are not. For what it’s worth, I’d do this for myself and strongly encourage any friends and family members the same way if they encountered this. If traditional approaches are not resolving the problem, why not give it a try? Even a shorter fast of 4 days could be enough to see if it helps.
My two cents. Thoughts, prayers, and best wishes, my FRiend.
I’m very sorry to hear of your diagnosis.
Three day fast (at least) before chemo is another one to try.
My wife rejected chemo until it was too late.
We tried HBOT, hyperbaric oxygen therapy, but no change.
I think a very low carb diet extended her life about six months.
Thank you for the post. It means a lot.
Thank you kindly, Mama.
Thanks for the prayers and kind thoughts. I love Mustangs too.
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