Posted on 04/29/2022 3:07:11 PM PDT by ConservativeMind
The immune system remembers. Often this memory, primed by past encounters with threats like bacteria or viruses, is an asset. But when that memory is sparked by internal drivers, like chronic inflammation, it can prove detrimental, perpetuating a misguided immune response.
In a new paper, researchers demonstrated that recipients of a bone marrow transplant were predisposed to more severe arthritis if their donor had inflammatory gum disease.
The researchers note that this mechanism may also prompt a reconsideration of how bone marrow donors are selected.
…To put the whole picture together regarding the link between inflammatory conditions, the "critical experiment," as Hajishengallis explains, was a bone marrow transplant. Mice that had periodontitis, a severe form of gum disease, served as donors, as did a group of healthy mice serving as controls. Stem cells from their bone marrow were transplanted into mice that had never had gum disease and which had had their own bone marrow irradiated. A few months later, these mice were exposed to collagen antibodies, which trigger arthritis.
"Mice that received the transplant from mice with periodontitis developed more severe arthritis than mice that received a donation of stem cells from periodontally healthy mice," says Hajishengallis.
"And higher joint inflammation in recipient mice was due to inflammatory cells deriving from the periodontitis-trained stem cells," says Chavakis.
Further experiments suggested that the signaling pathway governed by a receptor for the molecule IL-1 played a vital role in contributing to this inflammatory memory.
The work underscores that blocking IL-1 receptor signaling could be an effective approach to mitigate against these knock-on effects of trained immunity.
"We've seen anti-IL-1 antibodies used in clinical trials for atherosclerosis with excellent results," Hajishengallis says. "It could be that it was in part because it was blocking this maladaptive trained immunity."
(Excerpt) Read more at medicalxpress.com ...
Thank you for the encouragement, AAABEST.
I’m behind on my review of study write ups this past week, but I hope to get caught up by Monday. I was out of town and was pretty busy.
Doing that and posting them takes a decent amount of time and it doesn’t help that I do these on my phone. 🙂
The best turmeric, according to ConsumerLab.com, was Doctor’s Best C3 Complex Curcumin.
It is an honor to help you and so many others, here.
Speaking of Tumeric…..
It does work. I use it for inflammation (mostly arthritis) and I also give it to our 12 Year old Lab Retriever. You have to be sure to get it from a quality source and it’s best if it also includes black pepper. I get mine from gaia herbs. being a Christian I am not fond of their name, but they grow their Tumeric locally and I know the people who work there and trust them.
She hasn’t eaten wheat in many years.
it’s not just bread... there’s wheat in so many things like noodles and gravies...Is she really diligent about it?
I can tell if I’ve accidentally had something with wheat in it (if I didn’t check) just because of the joint pain I feel the next day. My joints feel terrible for a few days.
Oh yeah. She’s extremely careful about what she eats for a number of reasons.
Me: Not so much. :-)
for future reference
Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.