Posted on 04/29/2022 3:07:11 PM PDT by ConservativeMind
The immune system remembers. Often this memory, primed by past encounters with threats like bacteria or viruses, is an asset. But when that memory is sparked by internal drivers, like chronic inflammation, it can prove detrimental, perpetuating a misguided immune response.
In a new paper, researchers demonstrated that recipients of a bone marrow transplant were predisposed to more severe arthritis if their donor had inflammatory gum disease.
The researchers note that this mechanism may also prompt a reconsideration of how bone marrow donors are selected.
…To put the whole picture together regarding the link between inflammatory conditions, the "critical experiment," as Hajishengallis explains, was a bone marrow transplant. Mice that had periodontitis, a severe form of gum disease, served as donors, as did a group of healthy mice serving as controls. Stem cells from their bone marrow were transplanted into mice that had never had gum disease and which had had their own bone marrow irradiated. A few months later, these mice were exposed to collagen antibodies, which trigger arthritis.
"Mice that received the transplant from mice with periodontitis developed more severe arthritis than mice that received a donation of stem cells from periodontally healthy mice," says Hajishengallis.
"And higher joint inflammation in recipient mice was due to inflammatory cells deriving from the periodontitis-trained stem cells," says Chavakis.
Further experiments suggested that the signaling pathway governed by a receptor for the molecule IL-1 played a vital role in contributing to this inflammatory memory.
The work underscores that blocking IL-1 receptor signaling could be an effective approach to mitigate against these knock-on effects of trained immunity.
"We've seen anti-IL-1 antibodies used in clinical trials for atherosclerosis with excellent results," Hajishengallis says. "It could be that it was in part because it was blocking this maladaptive trained immunity."
(Excerpt) Read more at medicalxpress.com ...
There are drugs that can, as well.
I take fish oil and use Turmeric.
FWIW CM - I read nearly every one of these health/medocal posts of yours.
You’re an asset to FR.
Lower carbohydrates, and a mostly animal, fruit, vegetable, nuts & seeds diet works best for myself and many I speak with.
Paleo…
TDS is principle cause of inflammation of ego.
How one inflammatory disorder exacerbates another.
Sort of like how Xiden and Harris feed off each other. Now there’s a pair of inflammations if I’ve ever seen them.
My world and you are welcome to it.
How well does it work? I have some issues with inflammation and T3 only solved a some of them.
It’s very hard to single out. I have a greens drink in the a.m..
I lift and sprint 3 days a week with some yoga on off days.
I eat mostly Paleo.
I meditate twice a day.
Sleep 7-9 hours a night.
Take Vitamins C, D3, Quercetin, and Zinc.
Nighttime before bed, I take Magnesium.
Occasionally take a random Aspirin.
Fish oil daily with occasional skipping a day.
Everything adds up. :)
6’2” 215lb and mostly lean. 200 is very lean.
Mid 40’s no health issues
Lifting for 33 years
Training for Masters T&F
I feel great, but not 21 y/o.
That sounds like a really great routine.
I take the D3, Quercertin, Zinc, Magnesium, Selenium, B12 and a multi. I’m looking for something that will help with some inflammation and have been on the fence about fish oil.
My doctor told me they investigate these natural herbs, and they almost always turn out to be of little or no value. But Turmeric is an exception. He said they found it far outperforms the claims made by its proponents.
You have to take other vitamins with Turmeric to avoid any allergic reactions
I am not sure what, exactly, but I take a lot of zinc magnesium vitamin B complex LOTS of vitamin D and some other things
I haven’ figured out what stops the allergic reaction but I can eat turmeric again.
I rotate between Carlson’s Fish Oil and their Cod Liver Oil.
https://www.amazon.com/Carlson-Omega-3s-Norwegian-Sustainably-Sourced/dp/B001LF39RO
https://www.amazon.com/Carlson-Omega-3s-Norwegian-Sustainably-Sourced/dp/B003B3P4PO
None of my family have had problems with turmeric.
My wife has started drinking a homemade turmeric tea for joint pain.
One major problem with DHA/EPA:
The effects are totally negated by omega 6. I describe such an action in my book as analogous to painting over dry rot.
This paper describes what I label a ‘chain problem’ relative to health matters. In non-health matters it is described as “Cause-and-Effect Chain.”
A distinct minority of the population is capable of troubleshooting a chain problem, be it mechanical, electrical, chemical, engineering or - in this reference - biological. Even fewer doctors possess this trait (which CANNOT be trained; it is innate).
I am an expert. Consider my abilities to be doctorate level.
In my book I describe my own approach to such problems in layman’s terms (an unpublished book in rewrite now directed at medical professionals rather than the public) but it’s irrelevant here.
This statement in the linked article defies a logical explanation:
“Different mechanisms have been proposed, but no one unifying mechanism could explain this bidirectionality.”
Then this:
“We’ve seen anti-IL-1 antibodies used in clinical trials for atherosclerosis with excellent results,” Hajishengallis says. “It could be that it was in part because it was blocking this maladaptive trained immunity.”
My God in Heaven. /s Some reading this will understand my disdain for that statement.
My point is that this paper is yet more evidence of M&M at work, trying to make sense of a public health disaster which eclipses the so-called ‘coronavirus pandemic’ by an order of magnitude.
But they will never make sense of it. They will only complicate it further, exacerbating public health threats with their efforts.
Look at the life expectancy & mortality stats over the past 25 years before calling me a liar.
What we have here is direct evidence of very smart, educated people demonstrating that - in terms of solving problems - they are very truly dumb.
I didn’t, at first
But I was taking a lot
After a few years tge side of my face would get swollen really bad.
I mean it I had something with mustard it was enough turmeric to set it off
Buy make sure you also eat black pepper
Thanks, again, for these posts.
Tell her to stop eating wheat
Also eat coconut oil and jello!!!
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