Grape seed powder improves renal failure of chronic kidney disease patients (Two grams of grape seed powder (not extract) daily for six months made eGFR improve 18.7% for Stage 2, 3, and 4 sufferers)

EXCLI Experimental and Clinical Sciences Journal ^ | June 27, 2016 | Khaoula Turki et al

[ConservativeMind]

CKD patients with renal failure (stages 2, 3, 4) were recruited as volunteers for a randomized double blind and placebo control pilot study. All patients suffered from diabetic nephropathy and hypertension. All patients were asked to keep their habits and medication as usual and were dispatched into two groups: experimental and placebo.

The GSE group was daily supplemented with six capsules of GSE, each capsule containing 350 mg of grape seed powder. Two bottles, 90 capsules each were provided to each patient for one month during the entire six months long study. The placebo group received starch.

GSE was processed from a grape cultivar (Carignan) of Vitis vinifera from northern Tunisia. Seeds were carefully separated from skin, washed, dried and grounded with an electric grounder until a fine powder was obtained. After mixing with 3 % colloïdal silica as excipient, the powder was conditioned into capsules weighting approximately 350 mg.

GFR was calculated by the Modification of the Diet Renal Disease (MDRD) method.

GSE increased 1/plasma creatinine ratio by 19.42 %, p = 0.044), and decreased proteinuria by -32.67 %, p = 0.041) but had no significant effect on plasma urea and uric acid. Moreover GSE slightly improved GFR by +18.70 % (36.74 ± 5.74 versus 43.62 ± 3.68, p = 0.604)

First of all GSE improves some kidney function parameters as it enhances GFR and clearly lowers proteinuria. This result is of utmost importance as reduction in proteinuria to the lowest achievable level is an important predictor of long term renal protection.

Importantly no patient drop out of the study nor adverse side effects were noted during the entire clinical trial period. Our data corroborate several previous works in the field demonstrating the heightening of oxidative and inflammatory biomarkers along with a decrease in antioxidant biomarkers in CKD patients.

[ckilmer]

better than zero flush is timed release niacin

[LittleBillyInfidel]

Interesting! I’ll bet that’s much for effective, too. Thanks!

[devere]

If you gentlemen had read the article in the link I posted you would have read that no-flush niacinamide also is documented to have the same kidney protecting effect as niacin. Unfortunately the inositol nicotinate you take from Finest Nutrition (“Finest Nature” doesn’t seem to exist), which is marketed as no-flush niacin, so far as I can discover has not yet been proved to have the same kidney-protective effect. Maybe it works, and maybe it doesn’t. Since it only takes 100 mg of niacin or niacinamide for a proved kidney protective effect, it seems wise to me to do that, flush or no flush. Personally I have been taking 100 mg of niacin twice a day, and the flush is usually very mild. Good luck with your health.

[kalee]

For later

[T-Bird45]

I did read the link, just not every jot and tittle of it, as I was interested in dosing and length of the study for observing the effects. I’ll return to the link for the niacin info.

[LittleBillyInfidel]

Unfortunately the inositol nicotinate you take from Finest Nutrition (“Finest Nature” doesn’t seem to exist),

Yes, correct, sorry... Finest Nutrition, not "Nature". Good catch. I need to also reread the article.

[Delta 21]

I had a gut issue a decade or more ago. Ended up using Black Currant Seed oil for about 9 months and it cleared it right up.

[Delta 21]

...ooops, down the wrong rabbit hole I think.

[TTFX]

Having a lot of stored vitamin a causes kidney problems.

Many foods have added vitamin a. Cooked carrots have a lot of vitamin a.

Consuming beer or yogurt reduce excess vitamin a.

[ConservativeMind]

I take that, or borage seed oil, everyday, but I am not aware of an impact on kidney function.

I simply take it because the GLA component is important to general health.

[T-Bird45]

Good to know about the vitamin A - I do love some cooked carrots but I don’t do them to excess because of the sugar.

Your comment about beer and yogurt being good for reduction of vitamin makes me think their common creation process is fermentation. I drink very little beer these days but I do consume yogurt. I also like other fermented foods like pickles and kim chee. I get them from OliveMyPickle.com

[Faith65]

Thanks. BKMK

[Delta 21]

The GLA and the BCSO black currant seed oil, helps your gut get rid of some bad gut bug. I have tried it since but no other improvements and I stopped because I thought I was getting too much Omega 6. I cant take fish oil. Think I may need to look at it again. My diet has changed.