Herbal compound prevents colon cancer in mice (Emodin)

Medical Xpress / American Physiological Society / American Journal of Physiology-Gastrointestinal ^ | Mar. 9, 2022 | Alexander T. Sougiannis et al

[ConservativeMind]

The active compound in Chinese herbs called emodin can prevent colon cancer in mice, according to researchers at the University of South Carolina School of Medicine. Physiologists conducting this study say this is likely due to emodin's ability to reduce the number of pro-tumor macrophages (a type of immune cell that can promote tumorigenesis). The study is published ahead of print in the American Journal of Physiology-Gastrointestinal and Liver Physiology and has been chosen as an APSselect article for March.

In addition to examining whether emodin could prevent colon cancer, researchers specifically wanted to know if its cancer-fighting properties "could be attributed to its actions on immune cells and particularly macrophages," said Angela Murphy, Ph.D., co-author of the study. Emodin was shown in this rodent model to reduce both polyp count and size. Also, mice treated with emodin "exhibited lower protumorigenic M2-like macrophages in the colon," researchers wrote in the study.

Colon cancer is the third most common cancer in men and women, and the third leading cause of cancer-related deaths in the U.S., according to the U.S. Centers for Disease Control and Prevention. It is expected to cause more than 52,000 deaths in the U.S. in 2022.

According to Murphy, approximately 70% of colon cancer cases can be attributed to diet or other lifestyle factors. This study raises hope that daily consumption of fresh fruits and vegetables containing emodin could prevent colon cancer in humans.

[ConservativeMind]

This is a component of knotweed, from which we get resveratrol.

The Chinese medicine called “Lianhua Qingwen” apparently has herbs that have a reasonable amount of emodin, if you can trust the other things in it.

[ConservativeMind]

More on emodin, here:

Emodin: A Review of its Pharmacology, Toxicity and Pharmacokinetics

https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC7168079/

[ConservativeMind]

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[packagingguy]

Curcumin works quite well also, especially when taken with boswellia:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4417447/

A lot of this research has been done at Baylor University Medical Center.

[George from New England]

These stories will be deleted by Big Pharma in 3,2,1

[steve86]

Will be taking the pair, along with other supplements, in about 15 minutes when I get home.

[entropy12]

I would prefer if all mice die from colon cancer, or any form of cancer actually. I hate those rodents. They spread disease like plague, eat stored foods, and breed like rats.

[entropy12]

My ancestors in India have been using turmeric for many millenniums in cooking. I understand it is rich in curcumin.

[packagingguy]

India was the reason tumeric/curcumin was found to combat colon cancer. Researchers wondered why colon cancer was almost non-existent there and discovered boswellia and curcumin were responsible.

[Bonemaker]

I need to know if it will work on a rat.😎

[Jane Long]

For the first time?

Or, something you’re already doing?

TIA.

[steve86]

Been taking them for years.