GlyNAC supplementation extends life span in mice (Equal parts glycine and NAC)

Medical Xpress / Baylor College of Medicine / Nutrients ^ | Mar. 8, 2022 | Premranjan Kumar et al

[ConservativeMind]

"Just like a car is subject to wear and tear over many years of use, limiting how long it works well, the natural aging process can progressively deteriorate the body and limit lifespan," said Rajagopal Sekhar.

His work contributes to providing a better understanding of how glutathione deficiency, increased oxidative stress, mitochondrial dysfunction and multiple additional hallmark defects of aging contribute to the aging process and how they can be reversed with GlyNAC supplementation.

"We were excited to find that the mice that received GlyNAC lived 24% longer than those that did not receive GlyNAC," Sekhar said. "We next wanted to understand how GlyNAC works."

In aged mice, the team found that all three organs had glutathione deficiency, oxidative stress, mitochondrial dysfunction, abnormal mitophagy (difficulty in disposing damaged mitochondria), impaired nutrient sensing and genomic damage. GlyNAC supplementation improved and corrected all these defects in the old mice. The researchers propose that it is the improvement of these fundamental biological defects that contributes to the animals' longer life.

"But mice are not humans. Could this happen in people? There is published evidence from our human studies showing that GlyNAC supplementation improves similar defects in people," Sekhar said.

For instance, in a pilot human clinical trial in older adults, Sekhar's group showed that taking GlyNAC for 24-weeks improved many characteristic defects of aging, including glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, insulin resistance, endothelial dysfunction, body fat and genomic damage. Importantly, the researchers also observed improvement in muscle strength, gait speed, exercise capacity and cognitive function.

Another exploratory human trial by his team investigated premature aging in people with HIV and showed that taking GlyNAC improved and corrected multiple similar defects to reverse premature aging and also increased strength, energy levels, cognitive function and quality of life.

[Ancesthntr]

“I’m reading that its better to take serine than glycine. why? because serine converts into glycine—but during the conversion process also ejects some methylation molecules that further drive metabolism.”

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Then why not take trimethyl glycine (TMG), which also has a bunch of methylation molecules? You can bulk order powder very cheaply (it is made from beets which are plentiful pretty much everywhere, and it is a waste product of beet sugar production).

[matthew fuller]

Thanks for posting this one, looks like a good one!

[xenia]

bk

[dennisw]

ping