Compound in the herb rosemary may be useful against COVID-19 and other inflammatory diseases (Carnosic acid supplement)

Medical Xpress / The Scripps Research Institute / ^ | Feb. 1, 2022 | Takumi Satoh et al

[ConservativeMind]

A team found evidence that the herb rosemary could be a two-pronged weapon against the SARS-CoV-2 coronavirus that causes COVID-19.

The scientists found that the compound, carnosic acid, can block the interaction between the SARS-CoV-2 outer "spike" protein and the receptor protein, ACE2, which the virus uses to gain entry to cells.

The team presented evidence carnosic acid has a separate effect inhibiting a powerful inflammatory pathway—a pathway active in severe COVID-19 as well as Alzheimer's.

"We think that carnosic acid is worth investigating as a potentially cheap, safe, and effective treatment for COVID-19 and some other inflammation-related disorders," says Stuart Lipton, MD, Ph.D.

In a 2016 study, Lipton showed that carnosic acid activates an anti-inflammatory, antioxidant signaling cascade called the Nrf2 pathway, and found evidence that it reduces Alzheimer's-like signs in mouse models of that disease, which is known to feature brain inflammation.

For the new study, Lipton, with Dorit Trudler, Ph.D., described their further studies of this anti-inflammatory effect on the immune cells that drive inflammation in COVID-19 and Alzheimer's. They proposed that this effect could be beneficial against the inflammation observed in COVID-19 and in some cases of the post-COVID syndrome known as long COVID, whose reported symptoms include cognitive difficulties often described as "brain fog."

Using a standard infectivity assay, he showed that carnosic acid can directly block SARS-CoV-2's ability to infect cells, with progressively greater infection-blocking activity at higher doses.

While the research is preliminary, the researchers propose that carnosic acid has this antiviral effect, despite being a safe and relatively unreactive compound, because it is converted to its active form by the inflammation and oxidation found at sites of infection. In that active form, they suggest, the compound modifies the ACE2 receptor for SARS-CoV-2—making the receptor impregnable to the virus and thereby blocking infection.

[ConservativeMind]

Hindsight Paragraph:
Bruno Latourette said, “COVID is...the perfect storm with pre-symptomatic contagiousness, a lethality that is not too high to lead to super-strong zero tolerance measures, a waning of immunity and high transmissibility”.

Even where they had complete, super-strong zero tolerance draconian measures, like travel to the South Pole, they brought it there.

Zero tolerance in liberal cities still has city workers, “essential” Walmart workers, and medical staff freely communicating COVID to everyone else.

[ptsal]

Is there a difference between fresh rosemary and dried?

Looks like another case for eating a healthy diet.

...a pox on big pharma...

[telescope115]

I’ve been drinking Schweppes tonic water for years-I love the stuff.
In a glass with ice and lime juice, I’ll go thru a liter in one evening. It’s great in the summertime, so refreshing. Having the quinine as a deterrent to COVID is an added benefit.

[AppyPappy]

Good because I just lost my sense of taste and smell. It’s very disconcerting

[ckilmer]

thanks. I added carnosic acid to my supplement stack.

I would say that the part of my supplement stack that gives the most protection against covid is now:
Vitamin C
Vitamin D
Zinc

Experimentally:
Quercetin
Glutathion
Carnosic Acid

I say experimentally because I’ve not had any colds for a decade or two. During most of that time I was only using the first three ingredients of the stack above.

I’d like to hear your take on what you consider to be your covid stack.

[ConservativeMind]

I only ever took my normal amounts of each of the following, before getting COVID last month:

- Vitamin C (time release) - 1,000 mg - 1,500 mg
- Magnesium (142 mg a day)
- Zinc (zinc methionine sulfate complex (OptiZinc) - 15 mg
- Vitamin D (5,000 IU, every other day)
- Benfotiamine (300 mg)
- Vitamin A (1,500 IU/day)
- Omega-3s (2,000 mg of Omega-3 fats within the capsules, a day)
- Curcumin (Curcumin C3 Complex 500 mg, once a day)
- Other vitamins and minerals, which might add more of the above, in small quantities.

That was all I took, by routine.

When I got COVID, I took additional stuff.

[ckilmer]

Since covid, I have increased my vitamin d to 10k iu every day and increased Omega-3’s to 4k mg daily.

My understanding was that vitamin A —like vitamin e tocopherols was not helpful

[ckilmer]

On vitamin D —my understanding is that optimum blood vitamin D levels are somewhere in the range of 60-80 ng/mL

Whereas normal/minimum recommended vitamin d levels might be in the 30-50 ng/mL range.

Do you understand differently?

[ConservativeMind]

I would agree.