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Bile acids may improve skin inflammation in patients with psoriasis (OTC bile supplements were used)
Medical Xpress / UC Davis / Journal of Investigative Dermatology ^ | Feb. 2, 2022 | Zhenrui Shi et al

Posted on 02/02/2022 9:20:08 PM PST by ConservativeMind

Taking bile acids or treatments that regulate their production levels may help control inflammation caused by psoriasis, a chronic skin condition.

Psoriasis, which causes itchy and painful scales and red patches on the skin, is linked to the body's immune system.

"Our studies showed that bile acids significantly inhibited skin inflammation without causing apparent systemic adverse effects," said Sam T. Hwang, professor.

What are bile acids?

Bile acids are produced in the liver and secreted into the first part of the small intestine to help digest food. While most bile acids are reabsorbed into the liver, a small portion escapes into the colon. There, they get transformed by the gut microbiota into secondary bile acids including lithocholic acid (LCA), deoxycholic acid (DCA) and 3-oxoLCA.

Bile acids are important in lipid absorption and cholesterol balance in the blood. Previous studies have identified their role as key signaling molecules in regulating skin immunity and inflammatory diseases.

Bile acids help alleviate a psoriasis-like skin condition in mice

They found that compared to mice receiving a placebo treatment, all the mice treated by any of the three secondary bile acids had less redness, scaling and ear thickness. The LCA bile acids showed the greatest improvement in ear swelling.

In another test, the scientists gave oral LCA to mice over two days before applying imiquimod, an immune response modifier used in treating skin diseases. They found that LCA-treated mice had less skin inflammation than those not given bile acids.

"Giving bile acids or using treatments that regulate the work of bile acids may be beneficial for controlling psoriatic inflammation," said Zhenrui Shi, visiting assistant researcher. "Our work provides an explanation for several prior small pilot studies of oral bile acid supplementation in psoriatic patients that resulted in improvement of their psoriasis."

(Excerpt) Read more at medicalxpress.com ...


TOPICS: Health/Medicine
KEYWORDS:
My wife has taken TUDCA and Jarrow Formulas Bile Acid Factors to help with a previous gall bladder problem (sludge found on a sonogram), and it eliminated those issues. I can say you need to start conservatively, because it can cause sudden diarrhea if taking too much.

This is a strange cure approach for psoriasis, but seems worth a try.

1 posted on 02/02/2022 9:20:08 PM PST by ConservativeMind
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To: Pete from Shawnee Mission; Mazey; ckilmer; goodnesswins; Jane Long; BusterDog; jy8z; ...

The “Take Charge Of Your Health” Ping List

This potentially high volume ping list is for health articles and studies which describe something you or your doctor, when informed, may be able to implement for your benefit.

Please email or private message me if you want on or off of this list.

2 posted on 02/02/2022 9:20:33 PM PST by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind

Very interesting, thank you for posting.

After I received my initial Shingrix Vax I developed a psoriasis patch, assuming it was a reaction to the adjuvant. I took the J&J jab a couple of months later, and that caused it to flare up dramatically- once again, an adjuvant type injection.

I’ll run this past my doctor, thanks again.


3 posted on 02/02/2022 9:28:55 PM PST by datura (Eventually, the Lord and the Truth will win.)
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To: ConservativeMind

Check this out...https://www.psoriasis-association.org.uk/forums/topic.aspx?ID=1314&page=42

It worked for me. Only been doing it for less than a month and results are showing. It’s a long thread...


4 posted on 02/02/2022 9:39:47 PM PST by HYPOCRACY (This is the dystopian future we've been waiting for!)
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To: ConservativeMind

PING


5 posted on 02/02/2022 9:43:31 PM PST by KamperKen (u)
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To: ConservativeMind

A comment on same subject from the Earthclinic.com site:

Home
Ailments

Cholecystectomy (Gall Bladder Removal) Remedies

Earth Clinic Team | Modified on Aug 14, 2020

Your gallbladder is an important gland that helps process the foods, particularly fats, that you eat, but sometimes this organ also causes problems. If you have had gallbladder issues, such as gallstones or even gallbladder attacks, you may be facing or even already undergone gallbladder surgery. However, treatment doesn’t stop just because the ill-functioning organ has been removed. A variety of natural cures, such as choline, betaine, lecithin, and others, help support regular digestive function and help you get back to as normal a lifestyle as quickly as possible.
What Is a Cholecystectomy?

Johns Hopkins Medicine defines a cholecystectomy as the surgical removal of the gallbladder. Your gallbladder is situated just beneath your liver in the upper right of your abdomen. This organ stores and concentrates bile, which is used by your liver to digest fat.
Why Would I Need My Gallbladder Removed?

According to Medline Plus, your gallbladder may be removed for two different reasons: (1.) you have pain or other symptoms from gallstones or (2.) your gallbladder is not functioning normally. Depending on the condition of your gallbladder, you may experience different symptoms. Common symptoms of gallbladder issues include indigestion, infection, nausea and vomiting, and pain after eating.
Do I Still Need Treated After Surgery?

While it may seem like all of your digestive issues should be solved after surgery, this really isn’t the case. You shouldn’t experience any more pain; however, you do need to take precautionary measures to support healthy digestion and to ensure that you are getting the proper nutrients you need. In addition to suggestions from your doctor, you can also utilize a number of natural treatments as support. Some of the best nutritional supplements following gallbladder removal include choline, betaine, and lecithin.
1. Choline

LiveStrong.com lists choline as an important nutrient following a cholecystectomy. This nutrient helps your body absorb fat and cholesterol and actually stimulates the production of lipoproteins in your liver. You can take choline as a supplement in doses of 3.5g per day for adults.
2. Betaine

Betaine is another nutrient that helps your body breakdown and absorb fats. This nutrient helps maintain your metabolism and also limits some of the side effects, such as bloating, gas, and diarrhea, following surgery. You can typically find betaine in capsule or powder form and should take a common dose of 1-2g
3. Lecithin

Lecithin is an additional supplement that supports digestive function following gallbladder removal. Research suggests that this substance keeps cholesterol from solidifying in your body and helps support your digestion of fats. You can get lecithin by eating foods such as oatmeal, eggs, and peanuts, or take 500 to 1,000 milligrams daily in the form of a supplement or powder.

Cleansing your liver using lemon oil or drinking diluted apple cider vinegar is also important following a gallbladder removal. Keep reading below for tips from our readers on more ways to support your digestive health after a cholecystectomy.

References:

Cholecystectomy
Cholecystectomy (Gallbladder Removal)
Gallbladder Removal
Supplements for Gallbladder Removal

Sort by
Gall Bladder/Liver Cleanse After a Cholecystectomy
Posted by Joanofarc83 (Morton, Illinois Usa) on 05/14/2010

I had my gall bladder removed years ago. I have done several liver cleanses with good results. I also have a fatty liver. Many stones came out as well as lots of chaff. The first cleanse produced over 100 stones. Google ‘Hulda Clark’ for the liver cleanse. The uses fresh lemon, grapefruit, olive oil, Epsom salts and water. Good luck.
1
Replied by Dennis
(Il)
08/24/2016

My wife just had a gall bladder removed. Now due to improper review there are some non blocking gall stones in the common bile duct. Would the Hulda Clark cleanse help that?
Gall Bladder/Liver Cleanse After a Cholecystectomy
Posted by Pat (Athens, Al, Usa) on 05/13/2010

I asked a question about a week ago but haven’t found an answer. i had my gallbladder removed in 1997 and wondered if I would still benefit from doing some type of cleanse. Obviously I can’t do a “gallbladder” cleanse since there isn’t one, but would a liver cleanse be essentially the same thing? And with so many out there and no gallbladder what would be one of the better home made cleanses to try? I know I’m asking a lot of questions but who else would know except all of you wonderful people? I just want to get and stay healthy and I’m sick and tired of being sick and tired. Thank You.
1
Replied by Pat
(Athens, Al, Usa)
05/14/2010

Thank you, I will google it and see what I can find. I just didn’t know it was doable without a gallbladder. So if it cleanses the liver it’s got to be good!

EC: Hi Pat,

You might find some good recipes here: https://www.earthclinic.com/cures/gallstones.html#GC

Improving Digestion of Beneficial Fats
Posted by Joan (Arcata, California, Usa) on 04/08/2010

Would you make a new listing under “ailments” for people who have already had their gall bladders removed? I would like to know suggestions for how to improve digestion of beneficial fats. I understand that people without gall bladders are more prone to nervousness in addition to bloating and even heart disease.

EC: Thanks for the suggestion! New ailments page created under “Cholecystectomy”.

2
Manuka Honey
1 User Review
5 star (1)
100%

Posted by Clatterbuck (Beltsville, Md) on 08/14/2020
5 out of 5 stars

[Editor\’s Choice] I seem to have accidentally discovered a cure for my post gallbladder removal issues. After the removal of my gallbladder a couple of years ago, I started having problems with needing to rush to the bathroom after I ate. Certain things seemed to trigger it but sometimes it seemed to come out of nowhere. It was really annoying. I also think all of the diarrhea was causing me to miss out on nutrients.

Last month, I had a sore throat and decided to use my usual sore throat remedy of manuka honey. This time my throat hurt pretty bad so I took a teaspoon in the morning and a teaspoon at night for a week. The sore throat went away like usual, but since then I haven’t had any diarrhea, not even after I drink coffee.

I haven’t even had any honey for two weeks and it still seems to be working. I don’t know if the manuka honey is what fixed the problem but it is the only thing I did differently before my stomach problems stopped.
7
Ox Bile
1 User Review
5 star (1)
100%

Posted by Claudi0 (Spring Hill, Florida) on 02/19/2013
5 out of 5 stars

https://www.earthclinic.com/cures/cholecystectomy.html#cleanses
Bile Salts: I had my gallbladder removed almost 5 months ago, it was loaded with gangrene. I healed nicely but the spasms continued. I did weeks of research on the Internet and decided to give ox bile 500 mg a try. I was uncomfortable all the time but of course more so right after eating. I am not a big eater; I munch a little during the day and eat a normal dinner. This ox bile is a freeze dried capsule you take just before you eat. This has been an amazing discovery for me. I found this product on line at a major vitamin mfg. And I don’t think I’ll ever be without it. I’ve been on this product for only one week and my discomfort level is 90 percent improved. As a side benefit, I’ve noticed that my scalp psoriasis is clearing up. I am totally amazed at the result of this product. I truly hope this helps someone. I have no bad side effects as I have read a very few experienced (bloating, gas, etc.).
9
Replied by Angela
(Texas)
01/08/2017


6 posted on 02/02/2022 9:48:26 PM PST by Norski (Justin Trudeau has tested positive for Coward-19.)
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To: ConservativeMind

Be careful with this..on the flip side the itch that comes with primary biliary cirrhosis is thought to be related to bike salts...also the itch pregnant women get.


7 posted on 02/03/2022 12:44:44 AM PST by RummyChick
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