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Could the Novavax Vaccine Help Us Win This COVID War? This More traditional technology may sway the vaccine hesitant
MedPage Today ^ | 1/29/2022 | Dr. Jesse Pelletier, MD

Posted on 01/31/2022 9:58:05 AM PST by SeekAndFind

It is often said that we are at war with COVID-19. The universal elements are all there. International leaders like Xi Jinping, Boris Johnson, and Scott Morrison have all invoked wartime rhetoric. The U.S. mobilized a "war effort" with unprecedented industrial and human resources to combat an enemy virus. Both sides of this conflict continue to evolve and learn. One recursive of prolonged battle is that an enemy can adapt to its opponent through new behaviors or technologies. When the U.S. embarked upon WWII, we had inferior training, battleships, and aircraft. By the end, the allies dominated the seas and the skies. During the late middle ages, the French and English battled for 116 years. This tumultuous period witnessed the evolution of new tactics, the longbow, and eventually gunpowder.

Our protracted war with COVID-19 is no different. Despite early losses, both self-inflicted and from a largely indefensible enemy we have advanced on all fronts. Our generals are preparing for another push forward with armamentaria to be used alongside first-generation mRNA weaponry. The newest battlefield intervention soon to debut: the Novavax vaccine.

Our time with COVID-19 has been nothing short of a grind. It is, in fact, easier to compare our experience to pitched battle as opposed to modern, technologically driven warfare. After the initial shock of worldwide spread eased, we hunkered down in our respective cities and towns, awaiting transmission of the virion particle like barbarians at the gate. When the time came to counterattack, we did so on the back of vaccines. The vaccines were our heavy mounted cavalry providing the shock tactics necessary for victory. These relatively new constructs containing encoded information were superb, slashing through enemy hordes by gutting infection, transmission, and poor outcomes. Now, some 2 years in, the cavalry is exhausted. And the enemy evolves.

Omicron is a cunning foe whose manifest destiny has unfolded before us in the crucible of the human body. A kind of hyper-speed Darwinian evolution has rendered it supremely able to infect, though less able to kill. It has learned from us how to optimize itself for maximum fitness. It is now able to partially side-step our cavalry, but that cavalry is more important than ever.

Approximately 87% of U.S. adults have had at least one COVID-19 vaccination. When this is viewed in context with the natural immunity imparted by the rapid spread of Omicron, the totality of immunity has rarely looked more sanguine. But there still is, and may always be, an element of stochasticity with this virus. While people with significant comorbidities are at highest risk for severe outcomes, every once in a while, it comes for the healthy. And still, millions of Americans refuse to be vaccinated.

Given the historical scope of vaccine hesitancy and our natural predilection for certain freedoms, we really deserve a collective pat on the back for a job well done rather than the de rigueur self-flagellation. But this is not the time for complacency.

We have yet another opportunity to drive vaccination that should not be squandered. Novavax will be looking for their U.S. emergency use authorization in short order. With international authorizations from the World Health Organization and European Medicines Agency, key partnerships with the Coalition for Epidemic Preparedness Innovations and the Serum Institute of India, and pending applications with the remaining Anglosphere, the company is well positioned worldwide. Novavax produces a recombinant protein subunit vaccine that reconstitutes spike without the need for genetic materials. The upshot here is that this construct has a significant history of use for diseases like pertussis, hepatitis B, and pneumococcus. In trials, the vaccine showed similar protection to currently available vaccines, and none of the participants experienced severe clotting, anaphylaxis, or myocarditis.

Novavax has disappointed many with an oft-delayed regulatory path and manufacturing difficulties, but they have a following that should not be underestimated. Social media and Reddit groups maintain a cult-like fanaticism for their marketed vaccine product known as Nuvaxovid or Covovax.

The stock, caught up in this fever but simultaneously throttled by a souring vaccine landscape, is as wild as a Yellowstone bucking bronco. But its real value may be in giving the un-jabbed another chance. Many unvaccinated do not see themselves as vaccine hesitant -- this label merely reflects the lens through which they are viewed in this highly politicized environment. In their defense, it has been egregiously unfair to brand the millions up to date with their schedules as "anti-vax" because of a one-time offense. This is their chance to square up.

The impending release of another vaccine offers a critical opportunity for institutions like the CDC and the media to get their messaging right. In order to do so, it is useful to understand that there exists a spectrum of "vaccine hesitancy," ranging from vaccine apathy to outright conspiracy. The extremes of the spectrum, and the shades of gray within, require precise messaging, communicated with empathy and compassion. The media, in order to avoid accusations of preference bias or worse, should deliver the same pomp and circumstance for this vaccine as it did for the likes of Pfizer and Moderna. Up to this point it has been eerily quiet.

If we are indeed still waging a pitched battle against this virus then it is time to refresh some of our chargers and give other beasts in the stable a chance. Vaccines will continue to be our best means to fight the enemy no matter how many therapeutics are advanced. Adding a protein subunit construct to the melee finally gives us the much needed, traditional option available for both the immunologically naïve and those hesitant to get boosted. It may provide a path forward for some who are pro-vaccine, but who drew the line at novel mRNA products. This is especially important given the disconnect that can exist between COVID-19 advocacy, science, and the manner in which this plays out in the realm of public policy. The Novavax option may indeed act as a compromise for some vaccine hesitant who are cornered by policies that squeeze healthcare workers, disregard naturally acquired immunity, require young and healthy adolescents to be boosted, or prevent children from leading more normal lives. Having another vaccine option just makes sense. It's just a shame it didn't arrive sooner.


Jesse Pelletier, MD, is a private practice ophthalmologist in Miami, and co-founder/chief medical officer of Veloce BioPharma. Pelletier reported he had no disclosures related to the Novavax vaccine.


TOPICS: Health/Medicine; Science; Society
KEYWORDS: covid; novavax; vaccine
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To: SeekAndFind

OFFS! Vax hesitant my rosy red. As with flu and pneumonia and shingles and whatever. I CHOOSE not to. It’s that simple.


21 posted on 01/31/2022 10:17:45 AM PST by rktman (Destroy America from within? Check! WTH? Enlisted USN 1967 to end up with this? 😕)
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To: ChildOfThe60s

Oh, a “brandon event”?


22 posted on 01/31/2022 10:18:34 AM PST by rktman (Destroy America from within? Check! WTH? Enlisted USN 1967 to end up with this? 😕)
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To: Regulator

How many recipients of the vax bothered to look up what ‘rna’(ribonucleic acid ) is and what part it plays in ones life? Ya can’t get unvaxxed.


23 posted on 01/31/2022 10:21:29 AM PST by rktman (Destroy America from within? Check! WTH? Enlisted USN 1967 to end up with this? 😕)
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To: EEGator

These people are lunatics. We can never eradicate risk, illness & death. This tunnel like focus engendered primarily by the desire for profit & control has caused great pain, suffering and economic destruction.
The flu vaccine varies from completely ineffective to perhaps 50% in a rare good year. People have been sold a pig in a poke. Fear and uninformed belief in”authority figures” are great salesmen. COVID-19 is an engineered pandemic.


24 posted on 01/31/2022 10:22:07 AM PST by JayGalt (For evil men to accomplish their purpose it is only necessary that good men should do nothing.”)
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To: SeekAndFind

You wanna win the COVID war? Then start the Nuremberg trials!


25 posted on 01/31/2022 10:23:01 AM PST by WKUHilltopper
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To: BenLurkin

“What “covid war?””

The Covid war is against the serfs, not the virus.


26 posted on 01/31/2022 10:25:14 AM PST by alternatives? (The only reason to have an army is to defend your borders.)
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****


27 posted on 01/31/2022 10:26:37 AM PST by PMAS (Vote with your wallets, there are 80 million of us - No China made, No Amazon)
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To: SeekAndFind

It is still morally and ethically compromised. No thanks!


28 posted on 01/31/2022 10:27:15 AM PST by frogjerk (I will not do business with fascists)
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To: JayGalt

F.U.D. sells, it’s a good racket.

A great way to get people in on it...lock them in their houses for two years and run we’re all going to die news 24/7.


29 posted on 01/31/2022 10:28:52 AM PST by EEGator
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To: Delta 21

Because they can and they don’t care about the value of human life.


30 posted on 01/31/2022 10:28:57 AM PST by frogjerk (I will not do business with fascists)
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To: JayGalt

The history of all flu bugs is they start out nasty then mutate to decreasing severity. They lose their “ooomph”. e.g.:
“What’s even more remarkable about the 1918 flu, say infectious disease experts, is that it never really went away. After infecting an estimated 500 million people worldwide in 1918 and 1919 (a third of the global population), the H1N1 strain that caused the Spanish flu receded into the background and stuck around as the regular seasonal flu.
But every so often, direct descendants of the 1918 flu combined with bird flu or swine flu to create powerful new pandemic strains, which is exactly what happened in 1957, 1968 and 2009. Those later flu outbreaks, all created in part by the 1918 virus, claimed millions of additional lives, earning the 1918 flu the odious title of “the mother of all pandemics.”
https://www.history.com/news/1918-flu-pandemic-never-ended


31 posted on 01/31/2022 10:32:41 AM PST by LouieFisk
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To: SeekAndFind

NFW.

I survived it and have persistent IgG antibodies to prove it.

No way in Hades will I submit to any of their Great Reset “vaccines.”


32 posted on 01/31/2022 10:41:32 AM PST by E. Pluribus Unum ("Communism is not love. Communism is a hammer which we use to crush the enemy." ― Mao Zedong [FJB])
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To: SeekAndFind

If it’s still useful I’d be happy to take the Novavax five years from now. Five years of human trials, is that asking too much?


33 posted on 01/31/2022 10:45:13 AM PST by Buttons12 ( )
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To: SeekAndFind

No injection falsely labeled as a vaccine is acceptable. Snake oil salesmen pushing this crap should be run out of town on a rail.


34 posted on 01/31/2022 10:57:22 AM PST by mass55th ("Courage is being scared to death, but saddling up anyway." ~~ John Wayne )
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To: SeekAndFind

I’m not vaccine hesitant. Pfizer Moderno etc. are not vaccines.


35 posted on 01/31/2022 11:04:18 AM PST by freedomjusticeruleoflaw (Strange that a man with his wealth would have to resort to prostitution.)
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To: SeekAndFind

I got a flu shot, which works against COVID better than any of the COVID vaccines.

Prove me wrong.


36 posted on 01/31/2022 11:05:34 AM PST by SaxxonWoods (If It Aint Woke Don't Fix It.)
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To: Sirius Lee

He may never have heard of herd immunity but he is well-schooled in drama and hyperbole.

This guy was so proud of his writing that he had to print it and frame it so he could see it all the time


37 posted on 01/31/2022 11:07:46 AM PST by ChildOfThe60s ( If you can remember the 60s.....you weren't really there..)
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To: SeekAndFind

“Approximately 87% of U.S. adults have had at least one COVID-19 vaccination.”

I call BS on that statistic - about 35% of the people I know haven’t taken one shot and I’m in NY


38 posted on 01/31/2022 11:17:01 AM PST by PMAS (Vote with your wallets, there are 80 million of us - No China made, No Amazon)
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To: SeekAndFind

I now distrust the medical community so much, I will not take any shots.

I never did take their flu shots, which they never called vaccines.


39 posted on 01/31/2022 11:20:20 AM PST by Lurkinanloomin ( (Natural born citizens are born here of citizen parents)(Know Islam, No Peace-No Islam, Know Peace)
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To: SeekAndFind

Nope


40 posted on 01/31/2022 11:22:21 AM PST by butlerweave
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