Posted on 12/15/2021 11:55:45 AM PST by ConservativeMind
A receptor activated by substances formed from omega-3 fatty acids plays a vital role in preventing inflammation in blood vessels and reducing atherosclerosis, a new study from Karolinska Institutet in Sweden reports. The discovery can pave the way for new strategies for treating and preventing cardiovascular disease using omega-3 fatty acids.
Cardiovascular disease is the most common cause of death globally and a serious public health problem. Atherosclerosis is associated with chronic inflammation in the blood vessels. Inflammation is normally controlled by stop signals called resolvins, which switch off the inflammation and stimulate tissue healing and repair through a process called resolution of inflammation. Resolvins are formed from omega-3 fatty acids and bind to and activate a receptor called GPR32.
"We've found that this receptor is dysregulated in atherosclerosis, indicating a disruption in the body's natural healing processes," says the study's first author Hildur Arnardottir, assistant professor at the Department of Medicine, Solna, Karolinska Institutet. "This discovery can pave the way for completely new strategies for treating and preventing atherosclerosis by arresting inflammation in the blood vessels, while also turning on the body's healing processes with the help of omega-3 fatty acids, for example."
The new study shows that signaling via the receptor actively stops inflammation in atherosclerotic blood vessels and stimulates healing. The researchers have studied atherosclerotic plaque and created a new experimental model with an over-expressed GPR32 receptor. The GPR32 receptor counteracted atherosclerosis and inflammation in the blood vessels, and resolvins that activate GPR32 enhanced the effect.
"We'll now be studying the mechanisms behind the failed management of inflammation in the blood vessels and how omega-3 mediated stop signals can be used to treat atherosclerosis," says the study's last author Magnus Bäck, senior consultant cardiologist and professor at the Department of Medicine, Solna, Karolinska Institutet.
(Excerpt) Read more at medicalxpress.com ...
Nattokinase is also great in combination
I think Krill oil has brought me back from the brink.
atherosclerosis
That be me
“”We’ll now be studying the mechanisms behind the failed management of inflammation in the blood vessels and how omega-3 mediated stop signals can be used to treat atherosclerosis,” says the study’s last author Magnus Bäck, senior consultant cardiologist and professor at the Department of Medicine, Solna, Karolinska Institutet.”
One major caveat: The quality of Omega-3 if not sourced from fish. I’ll bet that most FReepers don’t even understand that Chia/Flax supplies a mere 3% of what they claim on packaging which contains it as an added ingredient.
Humans ain’t birds. Furthermore, most sources of bottled/supplemental O-3 is absolute crap.
i.e., you get what you pay for. It will be interesting to see what results if they mandate a USP Omega-3 as a medical treatment as opposed to its current use as an unregulated supplement.
Might you be the one who told me about a “vein scrubber” substance.
Dunno but Japanese have higher blood pressures because of all the salt and alcohol they consume but they also eat natto...probably the reason why they’re finding out nattokinase is so beneficial.
My understanding is that ALA converts at a 15% efficiency into DHA or EPA.
natto has lots of vitamin k2—which you want to pair with vitamin d3. the k2 increases the amount of HDL —which in turn shovels the plaque out of your arteries.
the other common pairing is b12 with omega 3. these two together are protective against alzheimers.
I have been reading lately that b12 and omega 3 together are protective against alzheimers.
the dosage that I’ve been reading about lately for omega is about 4 grams a day.
How about you?
Not veins. Arteries. I have atherosclerosis too, and many stents. I was given a quality fish oil by prescription but it’s hell on my stomach.
We currently take two Spring Valley (Walmart) Omega-3 fish oil pills, which, with two, provides 1,290 mg of EPA and 620 mg of DHA. ConsumerLab showed the Spring Valley passed its tests and was the least expensive. We also get salmon with skin in our diet, at least once or twice a week, on average. In particular, Costco has a wild refrigerated sockeye (red) salmon now that is quite tasty, for $12.99 a pound. Sams Club has it for $10 a pound, but it does not taste quite as good, so it's a different source or location.
Salmon has both fats in it, and the studies show both are used and that salmon itself is the best source, so I think two grams of actual Omega-3s a day with the supplemental we get is a healthy amount, per week.
When the red salmon goes away, we'll go back to frozen sockeye or pink Atlantic salmon.
“Arteries”
corrected
I researched it in depth years ago and came to the conclusion that 3-5% was average, higher among females for reasons which still elude my understanding, but far from approaching 15%.
Admittedly I haven’t looked at it since, but I doubt the reality is much different. Food marketing is rife with blatant fraud.
And those numbers were among the healthy, meaning the real numbers are FAR lower, given the state of health of people in this country these days.
Worse, most people destroy omega 3 in fish through improper cooking.
I moved to freshwater trout after the Tohoku quake for reasons which shouldn’t need elaboration.
Found this:
“ALA can be converted into EPA and then to DHA, but the conversion (which occurs primarily in the liver) is very limited, with reported rates of less than 15% [3].”
https://ods.od.nih.gov/factsheets/Omega3FattyAcids-HealthProfessional/
Um, yeah. From the same government that gave us the food pyramid, the ‘vaccines’ and treatment protocols that have killed hundreds of thousands?
C’mon, man.
It’s a scam, no different than the lipid hypothesis. Humans aren’t birds. Omega 3 PUFA is very, very fragile and often destroyed in the cooking process. Even flaxseed oil is of questionable value due to processing, and still only contains ALA.
Most Americans haven’t any idea how damaging their decisions are to health. I stick by my 3-5% conclusion and maintain that everything else which follows - NIH citations, manufacturer packaging claims & supplement advertisements - fall under the same banner as NIH COVID treatment protocols.
The worsening health of the populace is evidence to those claims. I expend over significant content of my books to the role of inflammation and omega-6. There is a causal relationship.
Eat fish, folks - cooked/prepared properly to not destroy the O-3 - take care of your gut, and SIGNIFICANTLY reduce omega 6 intake, otherwise the net benefit is STILL negative for health.
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