Deleting dysfunctional cells alleviates diabetes (Senolytics like quercetin)

Medical XPress / University of Connecticut / Cell Metabolism ^ | Nov. 22, 2021 | Ming Xu, et al

[ConservativeMind]

Eliminating old, dysfunctional cells in human fat also alleviates signs of diabetes. The discovery could lead to new treatments for Type 2 diabetes and other metabolic diseases.

The cells in your body are constantly renewing themselves, with older cells aging and dying as new ones are being born. But sometimes that process goes awry. Occasionally damaged cells linger. Called senescent cells, they hang around, acting as a bad influence on other cells nearby. Their bad influence changes how the neighboring cells handle sugars or proteins and so causes metabolic problems.

Type 2 diabetes is the most common metabolic disease in the US. About 34 million people, or one out of every 10 inhabitants of the US, suffers from it. Most people with diabetes have insulin resistance, which is associated with obesity, lack of exercise and poor diet. But it also has a lot to do with senescent cells in people's body fat. And clearing away those senescent cells seems to stop diabetic behavior in obese mice. Alleviating the negative effects of fat on metabolism was a dramatic result, the researchers said. If a therapy worked that well in humans, it would be a game-changing treatment for diabetes.

Xu and his colleagues tested the efficacy of a combination of experimental drugs, dasatinib and quercetin. Dasatinib and quercetin had already been shown to extend lifespan and good health in aged mice. In this study, they found these drugs can kill senescent cells from cultures of human fat tissue. The tissue was donated by individuals with obesity who were known to have metabolic troubles. Without treatment, the human fat tissues induced metabolic problems in immune-deficient mice. After treatment with dasatinib and quercetin, the harmful effects of the fat tissue were almost eliminated.

"These drugs can make human fat healthy," says Xu.

[CAluvdubya]

I added Quercetin to my daily vitamins about a month or so ago. No weight loss yet but it’s early. That would be a nice perk. Those pills are kind of big!.

[CAluvdubya]

I get Jarrow Formulas Quercetin, 500mg., one a day. I get my supplements from Swansonvitamins.com. Good prices, good service. I’ve gotten knock-offs from Amazon in the past, so be careful when you use them.

Thanks for the info.

[Joshua]

most diabetics can’t fast. that is the problem.

fasting causes unsafe drops in insulin levels.
*************************************************************I stopped taking the insulin (180 units a day) and began fasting. I have maintained an A1C under 6.5 and have not used insulin in over 3 years.

[cherry]

how much quercetin do you take daily?...and where do you get it?....I ordered some but it seemed a little spendy....

[wastedyears]

No more beer??????

[ryderann]

See #13.

[ckilmer]

Doesn’t fisetin have the strongest effect? Seems to me I’ve seen a graph around that ranked the senolytics according to their strength.

No sure if this is really relevant because the different senolytics may target different tissues in the body. As, for example, fisetin targets fat cells.