Reduction in coenzyme A levels linked to heart failure

Reduced levels of coenzyme A (CoA) worsen heart failure and likely help exacerbate cardiac dysfunction during heart failure, according to a new study. In addition, the findings suggest certain metabolic pathways may be disproportionately affected by reduced CoA levels.

CoA is a critical molecule in the metabolism. Fluctuations in the amount of the enzyme are often observed in foundational development of many diseases, such as cancer and diabetes. Prior to this study, the link between CoA levels and heart failure had not been investigated. Using mice that lacked a specific enzyme for CoA production, physiologists at the Diabetes and Obesity Center at the University of Louisville School of Medicine in Kentucky tested whether reduced CoA levels contribute to heart failure.

The research team uncovered that gene expression of a key CoA synthesizing enzyme is decreased during heart failure. This suggests CoA biosynthesis may be limited during heart failure, worsening the condition.

"We think reductions in CoA availability may impair the intrinsic metabolic flexibility of the heart," said Timothy Ndagi Audam, Ph.D., a postdoctoral fellow and the study's first author. "With this understanding, we are now pursuing an approach to increase CoA levels in the heart. Because the failing heart is already energy starved, an approach aimed at sustaining or improving cardiac energetics through increasing CoA levels may be a viable treatment option for managing heart failure."

C.M. Thanks!

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https://askinglot.com/what-is-the-precursor-of-coenzyme-a

"Coenzyme A or CoA is derived from pantothenic acid and adenosine triphosphate (ATP) and used in metabolism in areas such as fatty acid oxidization and the citric acid cycle. Its main function is to carry acyl groups such as acetyl as thioesters.

what vitamin is a precursor of CoA sh? Pantothenic acid (PA) is a B vitamin that is a component of coenzyme A (Figure 2). Coenzyme A is necessary for the metabolism of carbohydrates, amino acids, fatty acids, and other biomolecules. As a cofactor of the acyl carrier protein, pantothenic acid participates in the synthesis of fatty acids.

Subsequently, question is, what are the three components of coenzyme A?

The monster coenzyme A (CoA) consists of three parts:

The body: vitamin B5.
The head: a form of ADP.
The tail: beta-mercaptoethylamine.

WHAT IS A in coenzyme A?

Coenzyme A is a coenzyme containing pantothenic acid, adenosine 3-phosphate 5-pyrophosphate, and cysteamine; involved in the transfer of acyl groups, notably in transacetylations."

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****B5 is pantothenic acid.

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See this 2005 article:

https://pubmed.ncbi.nlm.nih.gov/15705257/

Abstract

"The most concerning adverse reaction with HMG-CoA reductase inhibitors (statins) is myotoxicity. Statins inhibit the production of mevalonate, a precursor of both cholesterol and coenzyme Q10, a compound believed to be crucial for mitochondrial function and the provision of energy for cellular processes. There is speculation that a reduction in coenzyme Q10 concentrations may promote the myopathies that have been associated with statin treatment as a result of mitochondrial damage. Although studies have repeatedly demonstrated a reduction in circulating coenzyme Q10 concentrations with statin therapy, it is unclear as to whether tissue levels of coenzyme Q10 are significantly affected. Coenzyme Q10 supplementation has been shown to reverse statin-induced decreases in circulating coenzyme Q10 concentrations, although the effect of supplementation on tissue coenzyme Q10 concentrations and any resulting clinical benefit has not been adequately assessed. Although there is not much of a safety concern with coenzyme Q10 supplementation, there is also not enough evidence to support its routine use for preventing the adverse effects of statin therapy, and it is therefore not recommended for this purpose at this time."

--------------------------------------------------------------------------------------------------------------------------------------------------------------- HMG-CoA reductase inhibitors (statins) is myotoxicity. Using Statins. This could be one possible "Subsequent step".

Using CoQ10.... "it is therefore not recommended for this purpose at this time."

I think there may be later studies that I did not see that would recommend supplementation. I would not use statins and I already use CoQ10. (That is enough for tonight!)

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