Posted on 11/12/2021 7:17:13 AM PST by BenLurkin
A single injection of a newly developed drug has been shown to reverse paralysis in mice with severe spinal cord injuries. By mimicking the extra-cellular matrix around the spine, the liquified drug promotes the regeneration of severed nerves and the repair of other vital tissues, allowing the rodents to regain the ability to walk within four weeks.
Describing this breakthrough in a new study in the journal Science, researchers explain how they injected synthetic nanofibers into the damaged tissue of mice 24 hours after making a cut in their spinal cords. Consisting of an array of peptides, these nanofibers quickly assemble into a gel around the wound and begin communicating with cells in order to promote healing.
This is achieved thanks to the release of two vital signals, one of which activates a receptor called b1-integrin in order to promote the regrowth of neuronal connecting arms, otherwise known as axons. The second signal, meanwhile, mimics a molecule called fibroblast growth factor 2, which helps neurons survive by supporting the development of other vital tissues such as blood vessels and myelin, which insulates nerve fibers.
(Excerpt) Read more at iflscience.com ...
Does it come in different flavors?
Interesting.
I wonder if it will work for old injuries as well as recent ones.
I don’t deliberating enjoy making any animals suffer. I found it difficult just reading about what Dr. Fauci put those puppies through years ago. However, there are instances when I would sanction such experimentation, as the only way to obtain certain data. If this can benefit human beings, that will be life changing for many people after profound injuries.
In order to find out if these mice could be healed with this gel, their little Mouse spines had to be broken or severed. Let’s put it this way, so long as they weren’t left to suffer needlessly or for prolonged periods, this presents an opportunity to learn.
deliberating = deliberately, by the way.
I can see this helping veterans and laborers, but I want it safely tested first.
“We are going straight to the FDA to start the process of getting this new therapy approved for use in human patients, who currently have very few treatment options.”
An interesting question, since it promotes regeneration, it may be possible to intentionally “re-injure” the severed nerve endings, that have been scarred over and treat this way.
I am sure some very smart minds will be working on this in the future if it continues to show promises
Science is getting freaky.
I looked for the oldest reference I could find on this substance. Apparently this has been around for quite some time and has plenty of research demonstrating its effectiveness in various diseases. This is from late 1990’s (from ncbi.nlm.nih.gov):
Eur Cytokine Netw. 1997 Dec;8(4):359-65.
Interleukin-6 receptor-interleukin-6 fusion proteins with enhanced interleukin-6 type pleiotropic activities
J Chebath 1, D Fischer, A Kumar, J W Oh, O Kolett, T Lapidot, M Fischer, S Rose-John, A Nagler, S Slavin, M Revel
PMID: 9459615
Abstract
An sIL-6R/IL-6 chimera, directly fusing the natural forms of soluble IL-6 receptor and IL-6, as found in human body fluids, was produced in transfected human cells. The secreted p85 glycoprotein was active at a concentration of 120 pM to produce growth-arrest and spindleoid differentiation of murine melanoma F10.9 cells, which do not respond to IL-6 alone. This fusion protein was as active as the yeast-produced p56 fusion protein containing a shortened sIL-6R, linked through a flexible peptide chain to IL-6 (Hyper IL-6). The concentration of Hyper IL-6 needed to arrest the growth of F10.9 cells was much lower than that needed of a combination of IL-6 and sIL-6R, added separately. Hyper IL-6 was also more active than IL-6 in stimulating growth of murine plasmacytoma T1165 cells, the half maximal stimulation being obtained at 2 pM Hyper IL-6 versus 23 pM for IL-6. In order to evaluate the effect of the fused sIL-6R/IL-6 proteins on human hematopoietic primitive progenitor cells, they were added to suspension cultures of CD34+ cells from human cord blood in addition to both flt3/flk2 ligand (FL) and stem cell factor (SCF). Fused sIL-6R/IL-6 produced a marked stimulation of cell expansion and a marked increase in the number of colony forming units when subsequently plated in semi-solid medium with IL-3, GM-CSF, SCF and erythropoietin. Ex-vivo maintenance and expansion of early progenitor cells in bone marrow transplantation protocols may be a potential application for the sIL-6R/IL-6 chimeric glycoproteins.
I wonder if mouse and human nervous systems are similar enough that this is likely to work in people.
Bookmarked !!
So you wouldn’t mind if we test it on Fauchi first? Asking for a friend.
I think that would be a capital idea.
If he weren’t so busy, so up in age, I’m certain the doctor would have already volunteered to make himself available for any and all specified discections!
He should definitely be subject #1!
I have a friend who has been in the hospital for about a month. A few days into his stint, my wife, a retired nurse, diagnosed him as having transverse myolitis (sp) and urged his wife to request a neural consult. She did, but the Drs. dragged their feet for three weeks, delaying IV antibiotics and steroids which likely would have saved him from his lower extremities paralysis he now has. I wonder if this new stuff would work for him.
Might be worth passing some info about it along to your friends. The developers might be looking for candidates to do trials with.
I wonder if it will work for old injuries as well as recent ones.
Unfortunately, it MAY not be a help for "old injuries".
What happens after a spinal nerve severing, the muscles stop receiving signals, so they atrophy, or "shut down", and gradually become nothing more then fibrous tissue. That tissue is not/will not be contractive, or functional, so it may be futile for the "long term" injuries.
So an injected substance communicates with cells.
Shouldn’t this be mocked as conspiracy theory stuff?
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