Posted on 09/14/2021 10:20:20 AM PDT by rxsid
Study Shows Vaccine Will ENHANCE Delta Infectivity
STORY AT-A-GLANCE
COVID-19 jabs continue to be pushed as the only solution to the pandemic, even as “breakthrough” infections increasingly occur. A group of Japanese researchers has also released research showing that the SARS-CoV-2 Delta variant “is poised to acquire complete resistance” to existing COVID-19 jabs like Pfizer and BioNTech’s BNT162b2,1 now being sold as Comirnaty.
What’s more, when four common mutations were introduced to the Delta variant, Pfizer’s mRNA injection enhanced its infectivity, causing it to become resistant. A Delta variant with three mutations has already emerged,2 which suggests it’s only a matter of time before a fourth mutation develops, at which point complete resistance to Pfizer’s jab may be imminent.
The spike protein used in mRNA COVID-19 vaccines consists of the original SARS-CoV-2 spike protein, without mutations. Multiple variants of concern (VOC) have emerged, however, which have numerous mutations and are highly infectious. As mutations increase, so do concerns over vaccine resistance and enhanced infectivity. As the researchers explained in bioRxiv, the preprint server for biology:3
“The receptor binding domain (RBD) of the spike protein binds to the host cell receptor ACE2, and the interaction mediates membrane fusion during SARS-CoV-2 infection.Neutralizing antibodies against SARS-CoV-2 are mainly directed to the RBD and block the interaction between the RBD and ACE2. Most SARS-CoV-2 variants have acquired mutations in the neutralizing antibody epitopes of the RBD, resulting in escape from neutralizing antibodies.”
When a single mutation was added to the Delta spike, most of the anti-RBD antibodies still recognized it. This wasn’t the case with four mutations, however, which the researchers called Delta 4+. Not only was Delta 4+ not recognized, but infectivity was enhanced:4
“… we analyzed the Delta 4+ pseudovirus with four additional RBD mutations. Surprisingly, most BNT162b2-immune sera enhanced infectivity of the Delta 4+ pseudovirus in a dose-dependent manner at relatively low concentrations of BNT162b2-immune sera, but showed weak neutralization only at the highest concentration of the sera.Especially, PFZ7 greatly enhanced the infectivity at relatively low serum concentration. Some sera, such as PFZ13 and PFZ14, did not show neutralizing activity even at the highest concentration of the sera.”
In short, while Pfizer’s COVID-19 jab still neutralized the Delta variant, when four common mutations were introduced to the RBD, the vaccine lost the ability to neutralize the variant and instead enhanced its infectivity.
Although Pfizer-BioNTech BNT162b2-immune sera neutralized the Delta variant, when four common mutations were introduced into the receptor binding domain (RBD) of the Delta variant (Delta 4+), some BNT162b2-immune sera lost neutralizing activity and enhanced the infectivity. This has implications for booster shots on the horizon as well, which are unlikely to be effective.
“A third round of booster immunization with the SARS-CoV-2 vaccine is currently under consideration,” the researchers explained. “Our data suggest that repeated immunization with the wild-type spike may not be effective in controlling the newly emerging Delta variants.”5
Despite the growing recognition that increasing injections may only make matters worse, President Biden said he has spoken with Dr. Anthony Fauci about giving booster shots at the five-month mark after the initial round of injections rather than waiting eight months, as previously suggested.6
A number of experts have raised concerns that COVID-19 jabs and the mass vaccination program could worsen the pandemic by triggering the development of new variants, via a concept known as antigenic, or immune, escape.
A general principle in biology, vaccinology and microbiology is that if you put living organisms like bacteria or viruses under pressure, via antibiotics, antibodies or chemotherapeutics, for example, but don’t kill them off completely, you can inadvertently encourage their mutation into more virulent strains. Those that escape your immune system end up surviving and selecting mutations to ensure their further survival.
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Already, variants have emerged that are showing signs of vaccine resistance. August 30, 2021, the World Health Organization highlighted the mu variant as a variant of interest (VOI), stating it has “a constellation of mutations that indicate potential properties of immune escape.”12
As of August 31, 2021, 39 countries had reported mu cases.13 The lambda variant, which WHO designated as a VOI on June 14, 2021,14 also shows signs of increased infectivity and resistance to vaccines. Writing in medRxiv, researchers from Chile noted:15
“Our results indicate that mutations present in the spike protein of the Lambda variant of interest confer increased infectivity and immune escape from neutralizing antibodies elicited by CoronaVac.These data reinforce the idea that massive vaccination campaigns in countries with high SARS-CoV-2 circulation must be accompanied by strict genomic surveillance allowing the identification of new isolates carrying spike mutations and immunology studies aimed to determine the impact of these mutations in immune escape and vaccines breakthrough.”
As further evidence of COVID shots’ waning effectiveness and the superiority of natural immunity, data presented July 17, 2021, to the Israeli Health Ministry revealed that, of the more than 7,700 COVID-19 cases reported since May 2021, only 72 occurred in people who had previously had COVID-19 — a rate of less than 1%. In contrast, more than 3,000 cases — or approximately 40% — occurred in people who had received a COVID-19 vaccine.16
In other words, those who were vaccinated were 6.72 times — nearly 700% — more likely to develop COVID-19 than those who had natural immunity from a prior infection. Speaking with journalist Daniel Horowitz, pathologist Dr. Ryan Cole explained that natural immunity produces broad immunity that can’t be matched by vaccination:17
“A natural infection induces hundreds upon hundreds of antibodies against all proteins of the virus, including the envelope, the membrane, the nucleocapsid, and the spike. Dozens upon dozens of these antibodies neutralize the virus when encountered again.Additionally, because of the immune system exposure to these numerous proteins (epitomes), our T cells mount a robust memory, as well. Our T cells are the ‘marines’ of the immune system and the first line of defense against pathogens. T cell memory to those infected with SARSCOV1 is at 17 years and running still.”
A retrospective observational study published August 25, 2021,18 also found that natural immunity is superior to immunity from COVID-19 jabs, with researchers stating, “This study demonstrated that natural immunity confers longer lasting and stronger protection against infection, symptomatic disease and hospitalization caused by the Delta variant of SARS-CoV-2, compared to the BNT162b2 two-dose vaccine-induced immunity.”
Further, according to a team of researchers from the Washington University School of Medicine, if you’ve had COVID-19 — even a mild case — you’re likely to be immune for life, as is the case with recovery from many infectious agents.19
Unfortunately, health officials aren’t making a distinction for those who have recovered from COVID-19 and continue to recommend injections for all, which may be adding fuel to the fire instead of extinguishing it.
Do you keep a dedicated thread for this? I’d like to bookmark.
Right. That’s what they put on the paperwork, and maybe even what the FDA’s premise for the EUAs as well. But that is not how they spun it in the media - at least not for a while now and the experts I listened to didn’t push that it would prevent disease - just lower risk of serious infection or worse.
I have no idea what the FDA was thinking to allow this on the paperwork; then again, I wonder how great the data the FDA had to work with was. It’s been a while since I looked at the trial data (and even then only a little bit) but it seemed to me at the time my impression was that there was only very small distinction in raw numbers between the drug and placebo groups. Just large enough trial participants that it showed a “statistically significant” outcome. And that was before Delta variant it was all on the original first virus.
Each of the 3 vaccines under EUA were tested in different groups, at different times, with different external factors, different regions etc. All of those could have inserted bias into the results which is partly why you got them saying “this one is 90% effective” and “that one is 75% effective”. We now know those claims are 100% BS.
But then, they went and broke the blind (gave the drug to the placebo arm patients) within a few months so you can’t even go back and see how these people fared (better or worse or no change) after 3 or 6 months. In almost any other case that would have been a protocol violation and the drug would have had to go back and start phase 3 all over again. But the FDA went ahead and gave Pfizer a full authorization anyway - even knowing from other third pata data that its protection wanes quickly. Totally unorthodox.
Working on something, time permitting. Stay tuned....
If you’re starting a ping list, please add me!
Have you seen this thread? Accounts of those from FR, https://freerepublic.com/focus/chat/3988541/posts (updated in post#131)
Those who were exposed to SARS in 2003 have the antibodies to SARS COVID-19.
They’ve been trying to reduce the population for years. Abort the babies and kill off granny at 75.
Hundreds of millions dead, and generations of people made sympathetic to depraved and calloused infanticide, if not actually participant in it.
I guess there must at least be 10 genuinely righteous men in the country.
When I get the posts done on this issue though, covid vaccines/breakthrough cases/hospitalizations/deaths, I shall ping you to them.
yes, but if you read that study through, it’s not just vaccinated. The previously infected reacts the same way, by producing autoantibodies.
However, the authors find the solution to a hypothetical D4 in the last part of the paper :
” When we analyzed the Delta-4+ pseudovirus, some sera from wild-type spike immunized mice showed enhanced infectivity” (that would be ‘naturally acquired”) and “Sera from the Delta-spike immunized mice did not exhibit enhanced infectivity at any concentration of sera. These data suggest that vaccines containing the Delta, but not wild-type, spike might be required to control the Delta subvariant that may emerge in the future.”
Bottom line is, wipe out Delta and other variants before they mutate further:
“These data suggested that the Delta variant completely escaped from anti-NTD neutralizing antibodies while maintaining functional enhancing antibody epitopes. Because the enhancing antibodies decrease the effect of anti-RBD neutralizing antibodies (Li et al., 2021; Liu et al., 2021b), there is a possibility that the Delta variant maintains the infectivity in the presence of anti-RBD neutralizing antibodies as a result of enhancing antibodies.”
“We analyzed these 16 anti-NTD neutralizing antibodies, and found that none of the anti-NTD neutralizing antibodies could recognize Delta spike (Figure 1A). In contrast, when we analyzed the binding of the anti-NTD infectivity-enhancing antibodoies (Li et al., 2021; Liu et al., 2021b), eight out of ten anti-NTD enhancing antibodies bound to Delta spike at levels comparable with wild-type spike “
” Anti-RBD neutralizing antibodies that bound to the Delta spike completely neutralized the infection of either Delta or wild-type pseudovirus (Figure 1C). All anti-NTD neutralizing antibodies we tested failed to recognize the Delta “
“s. Because the enhancing antibodies decrease the effect of anti-RBD neutralizing antibodies (Li et al., 2021; Liu et al., 2021b), there is a possibility that the Delta variant maintains the infectivity in the presence of anti-RBD neutralizing antibodies as a result of enhancing antibodies.”
“All anti-NTD monoclonal neutralizing antibodies from COVID-19 patients failed to bind to Delta spike whereas most of the enhancing antibodies maintained reactivity to Delta spike “
ping natural immunity
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