Posted on 09/10/2021 10:31:40 AM PDT by Qiviut
Abstract
Importance: Research is needed to demonstrate the efficacy of nasal povidone-iodine (PVP-I) against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Objective: To evaluate the in vitro efficacy of PVP-I nasal antiseptic for the inactivation of SARS-CoV-2 at clinically significant contact times of 15 and 30 seconds.
Interventions: The SARS-CoV-2, USA-WA1/2020 strain, virus stock was tested against nasal antiseptic solutions consisting of aqueous PVP-I as the sole active ingredient. Povidone-iodine was tested at diluted concentrations of 0.5%, 1.25%, and 2.5% and compared with controls. The test solutions and virus were incubated at mean (SD) room temperature of 22 (2) °C for time periods of 15 and 30 seconds.
Design and setting: This controlled in vitro laboratory research study used 3 different concentrations of study solution and ethanol, 70%, as a positive control on test media infected with SARS-CoV-2. Test media without virus were added to 2 tubes of the compounds to serve as toxicity and neutralization controls. Ethanol, 70%, was tested in parallel as a positive control and water only as a negative control.
Main outcomes and measures: The primary study outcome measurement was the log reduction value after 15 seconds and 30 seconds of given treatment. Surviving virus from each sample was quantified by standard end point dilution assay, and the log reduction value of each compound was compared with the negative (water) control.
Results: Povidone-iodine nasal antiseptics at concentrations (0.5%, 1.25%, and 2.5%) completely inactivated SARS-CoV-2 within 15 seconds of contact as measured by log reduction value of greater than 3 log10 of the 50% cell culture infectious dose of the virus. The ethanol, 70%, positive control did not completely inactivate SARS-CoV-2 after 15 seconds of contact. The nasal antiseptics tested performed better than the standard positive control routinely used for in vitro assessment of anti-SARS-CoV-2 agents at a contact time of 15 seconds. No cytotoxic effects on cells were observed after contact with each of the nasal antiseptics tested.
Conclusions and relevance: Povidone-iodine nasal antiseptic solutions at concentrations as low as 0.5% rapidly inactivate SARS-CoV-2 at contact times as short as 15 seconds. Intranasal use of PVP-I has demonstrated safety at concentrations of 1.25% and below and may play an adjunctive role in mitigating viral transmission beyond personal protective equipment.
Here’s to all the idiots who think they mean snorting straight povidone from the bottle.
-.-
Have you noticed that the FRoctors avoid these threads like the plague?
Anything involving natural preventing or early treatment using proven inexpensive products is ignored.
Piece is from 2020 posted today from what I can tell:
“The safety of povidone-iodine in the sinonasal and oral cavity has been well documented and we have shown that the SARS CoV-2 virus can be rapidly inactivated by a topical application,” says Tessema. “Studies have shown that the nasal and oropharyngeal cells are reservoirs for SARS-CoV2 infection. We believe that nasal and oral decontamination with PVP-I may play an adjunctive role in mitigating viral transmission beyond PPE.”
The researchers are also optimistic that this method can benefit those engaged in high risk activities outside of a dental or otolaryngologic setting.
“Anyone engaging in risky activities like barbers, hair dressers, or anyone coming too close to another person, may benefit from this simple method,” said Bidra.
ery good info at this link. Be sure to watch the short how-to video.
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